Submission + - New Drug Kills Cancer 20,000x More Effectively With No Detectable Side Effects (scitechdaily.com)
fahrbot-bot writes: SciTechDaily is reporting that researchers at Northwestern University have redesigned the molecular structure of a well-known chemotherapy drug, greatly increasing its solubility, effectiveness, and safety.
For this study, the scientists created the drug entirely from scratch as a spherical nucleic acid (SNA), a nanoscale structure that incorporates the drug into DNA strands surrounding tiny spheres. This innovative design transforms a compound that normally dissolves poorly and works weakly into a highly potent, precisely targeted treatment that spares healthy cells from damage.
When tested in a small animal model of acute myeloid leukemia (AML), an aggressive and hard-to-treat blood cancer, the SNA-based version showed remarkable results. It entered leukemia cells 12.5 times more efficiently, destroyed them up to 20,000 times more effectively, and slowed cancer progression by a factor of 59, all without causing noticeable side effects.
“In animal models, we demonstrated that we can stop tumors in their tracks,” said Northwestern’s Chad A. Mirkin, who led the study. “If this translates to human patients, it’s a really exciting advance. It would mean more effective chemotherapy, better response rates and fewer side effects. That’s always the goal with any sort of cancer treatment.”
For this study, the scientists created the drug entirely from scratch as a spherical nucleic acid (SNA), a nanoscale structure that incorporates the drug into DNA strands surrounding tiny spheres. This innovative design transforms a compound that normally dissolves poorly and works weakly into a highly potent, precisely targeted treatment that spares healthy cells from damage.
When tested in a small animal model of acute myeloid leukemia (AML), an aggressive and hard-to-treat blood cancer, the SNA-based version showed remarkable results. It entered leukemia cells 12.5 times more efficiently, destroyed them up to 20,000 times more effectively, and slowed cancer progression by a factor of 59, all without causing noticeable side effects.
“In animal models, we demonstrated that we can stop tumors in their tracks,” said Northwestern’s Chad A. Mirkin, who led the study. “If this translates to human patients, it’s a really exciting advance. It would mean more effective chemotherapy, better response rates and fewer side effects. That’s always the goal with any sort of cancer treatment.”
