Yeah. I did some charity work recently that involved standing mostly still for two days. It took over a month for my knees to recover enough that I could walk without limping again.
Standing still fucking hurts. Stand up meetings hurt, let alone a full day in the office.
I can sit in an office chair on the other hand for 70 hours in a week with no ill effect. I shuffle a LOT, which spreads the load and stops repetitive strain.