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Comment Re: Reason (Score 1) 80

I have a Tesla, the self driving is amazing I use it exclusively and it has driven me thousands of miles much of it urban with various scenarios youâ(TM)ll find it a city (like San Francisco â" I donâ(TM)t live there but I am there very often). I know people using it in Boston and NYC and other places. I will go so far as saying that FSD itself is already basically perfected. The only issues are it sometimes misreads speed limits not meant for it such as âoetrucks onlyâ and slows down for that. Rarely, it is overly hesitant on intersections and once in a blue moon it will phantom brake for a half second (noticeably, but not hard .. I am pretty sure the last time it did was last year on an older version of FSD). My only âoemajorâ complaint is the navigation. It often takes the long way, and also does things like turn into a far right lane when it should know that it has to take a left turn soon. Those donâ(TM)t have to do with the FSD itself but the directions engine (Mapbox/Valhalla), is terrible.

Comment Re:Neat case report, probably cannot scale (Score 1) 21

HIV treatment daily meds are less than $200 a month. There's a "one injection every six months" treatment that costs $30K per year currently (but will reduce to $40 a month next year when generics start being allowed.)

So a person on daily treatment would provide $1200 to the Pharma company for how long? A year? Or at best a decade, assuming no competitors .. which is unlikely. But let's say it's a decade. That's still only $12K the Pharma company can make off that person. If they made a full cure, they could charge $50K for it easily (remember, the once-every-6-months injection is $30K currently, which means people are willing to pay) .. so why wouldn't a company make a cure and charge $50K or even $100k for it? Some cancer meds that only increase lifespan by a month or two are going for $400k.

Comment Re:Reason (Score 4, Interesting) 80

It can. Reasoning according to the dictionary is "the action of thinking about something in a logical, sensible way" .. or by my own definition it's "identify a situation and make a decision towards a goal based on that situation."

Either way, an here's example of reasoning in a self driving car: Recognizing an object on the highway as an immovable road hazard, and making the decision to drive around it instead of hard-breaking due to the fact that there are no cars on the adjacent lane.

The car was taught, via simulator or training data, that if you don't check for hazards before switching lanes an accident will occur. It was also taught that hitting an object = bad. It knows the goal is to get to a destination and had to weigh the fact that if it hard braked, it would get to the destination later than if it went around the object and also be uncomfortable for the passengers. Therefore, in the situation where it won't hit another car or pedestrian, it would choose to go around rather than hard brake. That's "reasoning" .. doing a projection into the future and making a decision based on the optimal route.

Comment Re:Neat case report, probably cannot scale (Score 1) 21

He was trying to recreate the mutation, but from the data he published:

1. He didn't recreate the known good mutation (a 32 base deletion).
2. One of the kids is, in my opinion, DEFINITELY still susceptible to HIV as the induced mutation didn't induce a frameshift, and furthermore was heterozygous. And worse, there was likely mosaicism (not all the T-cells were derived from the cell that was mutated).
3. It's also unclear if the mutation in the second kid would actually have caused high levels of immunity, due to mosaicism.

Comment Re:Neat case report, probably cannot scale (Score 4, Insightful) 21

There's no reason this has to stay expensive. Most of the process can be automated.
That said, there's probably easier methods of curing HIV than total immune system depletion/reseeding. There is a "one pill every 6 months" treatment that keep the virus at undetectable levels (below 50 copies of the virus per 1 milliliter of blood).

The pace of HIV research slowed down because the treatments are so effective and cheap now. My guess is there'll be a low-risk total cure at some point, but it may be over a decade from now.

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