On the very good side, this will lower the cost and lead times for new drugs.

On the bad side, nation-states, terrorists, and even just Evil Agents Of Chaos[TM] who have access to tools like this and the knowledge to (ab)use them will be able to unleash biological chaos on the world.

Imagine if someone created a virus that infected everyone, spread rapidly, but was asymptomatic or had only common-cold-like-symptoms on everyone but their intended target, but it killed their target. The target could be an individual, a family that uniquely shared a mutation, or an entire ethnic group where the mutation was common in that ethnic group but rare outside of it.

Even worse, once unleashed, the virus will likely mutate and people or groups that are not the intended target may die, including the people who unleashed it.

I fear this is what is in our future.

The underlying filesystem has supported larger partitions all along. It's just the Windows UI tools didn't expose this.

... instead of doing 300 unrelated experiments, do 30 experiments and independently replicate each one 10 times.

At least then you'll know if you've got 30 repeatable experiments, 0 repeatable experiments, or something in the middle.

hacking.yeah

* Obvious life-imprisonment-felonies, like serious ads to recruit someone to assassinate the President of the United States

Beyond that, I've got nothing.

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OK, I lied, they will "touch" them long enough to call the FBI and let them deal with it.

Car dealer web sites have had configure-and-buy-it-online-except-for-the-final-signature for well over 20 years now, if you were willing to pay the fixed price the dealer offered.

Chat-bots that pretend to be your buddy have been around for awhile now, sometimes with tragic results.

10TB 3.5" drives are common enough. 1000 of those could easily fit in a station wagon.

The cost of maintaining a presence on X or just about any other top-20 social media platform isn't much. Even if every posts gets "only" 1000 impressions per year it's still cheap marketing.

There is a good reason to leave X though: If posting on X makes you look bad, then leave.

But don't use "it's not worth our time/money/resources" as an excuse, not unless or impressions-per-year drop well below current levels.

* No reasonable RAM upgrade path
* No reasonable storage upgrade path
* for some models, difficulty replacing battery

I would love to get something like the Apple Neo laptop if I knew I could extend its life to 8-10 years by upgrading hardware at the 4-5 year mark at a reasonable cost and replace the battery as needed at a reasonable cost.

Without those options, I'm looking at non-Apple hardware, which means a non-Apple OS and not being in the Apple ecosystem and not giving Apple the revenue stream that goes with being in that ecosystem.

I hope someone at Apple sees this and lets the right people know that their decisions to make hardware upgrades difficult or impossible is costing them future revenue.

At least one of the late-1980s/early-1990s Mac desktops and at least one IBM* enterprise-fleet-targeted desktop were designed for very fast in-the-field repair by corporate IT staff. By repair I mean "unscrew the case, replace the faulty component, screw the case back together, and get the customer back up and running ASAP."

I personally saw computers from both companies that had ONE screw, not counting customer-installed security screws/locking devices. Everything else was held in place by latches, friction, or other easy-to-manipulate no-tools-required connections. You could literally replace any one of the major components with less than 5 minutes of downtime once you'd done it a few times. Floppy drive, check, hard drive, check, power supply, check, motherboard, check, add-in boards, check, various cables, check, case, check. OK replacing the case might take 10 minutes but only because it requires moving all of the other components.

* IBM sold off its PC computing line to Lenovo in the 1990s or 2000s.

The future is to use AI to screen code before it is published to the world.

For code written or influenced by an AI, have a different, independently-developed AI screen it for security bugs.

They were named after people who did some pretty unsavory things during their times in power.

Doing unspeakably evil acts is part of many "successful business models." Whether it's mafia-style threats of "pay me or I will rape/kill your family," eliminate-your-competition/opponent mass-murders-and-take-their-property-as-spoils like you see in some wars ("ethnic cleansing" anyone?), or actually selling the "work product" of crimes (e.g. selling stolen goods or filming a rape and selling the photographs), there is money to be made from acts of evil.

Wait until people are dead long enough for most skeletons to come out of the closet before naming a building after someone.

640 days after death ought to be enough for most people.