There's really insufficient info lent to what the app is. Canned? Scale? Lifecycle? Only HPC. Connects to what. Needs what IO.
There are fat apps that may be more than sufficient for what's needed without VM/container/walls overhead of any kind.
Many variables are unstated and someone asking for the behavioral characteristics of processor families that Intel makes vs big hulking hardware generic platforms.
I can see wanting to use scale up/out ideas, but this is far too nebulous to call this a nail, as in the kind which you can hit with a hammer. It might be a hammer, looking for a nail, instead.