Comment Re:So what? (Score 1) 412
St. John's Wort is no more effective than placebo.
(Sources: Search for "effectiveness of X" and pick nih.gov or webmd)
OK, sounds like fun! Lets see... google "effectiveness of st john's wort"... pick the first NIH or WebMD link. Got it, that'd be this one:
Is there scientific evidence that supports the use of St. John's wort for depression?
There is some scientific evidence that St. John's wort may be helpful in treating mild depression, and the benefit seems similar to that of antidepressants. However, two large studies, one sponsored by the National Center for Complementary and Alternative Medicine (NCCAM), showed that the herb was no more effective than placebo in treating major depression of moderate severity; ironically, the conventional drugs also studied did not fare any better than placebo, either.
Hmm. So, according to the first link (that you recommended) St John's wort is about as effective (or ineffective) as conventional drugs. Only cheaper and with far fewer side effects (Source: ask anyone who's taken a conventional antidepressant)
Meanwhile, Wikipedia (with references) says:
An analysis of twenty-nine clinical trials with more than five thousand patients was conducted by Cochrane Collaboration. The review concluded that extracts of St John's wort were superior to placebo in patients with major depression. St John's wort had similar efficacy to standard antidepressants.
And what about side effects?
The rate of side-effects was half that of newer SSRI antidepressants and one-fifth that of older tricyclic antidepressants.[9] A report[9] from the Cochrane Review states:
The available evidence suggests that the Hypericum extracts tested in the included trials a) are superior to placebo in patients with major depression; b) are similarly effective as standard antidepressants; and c) have fewer side-effects than standard antidepressants. [...] St John's wort is generally well tolerated, with an adverse effect profile similar to placebo.[21]
Follow through with the references at your leisure.