Its very difficult to compare as in typing speed measurements one will either be limited to different people as well as different keyboard layouts, or at least different amounts of exposure to each layout. And what about some control cases of randomly generated layouts or alphabetical layouts?
An interesting hypothesis to test would be that any keyboard layout might have similar typing speeds (say give a factor of 2 or so) once a user has enough experience with it - for things that can be typed with single key presses.
I _do_ have some personal experience with the (standard 2-hand) dvorak keyboard layout which anyone can try by selecting that layout in their OS's keyboard settings (irrespective of their physical keyboard), a side effect of this is that you will be forced to learn to touch-type as obviously the letters written on your standard keyboard will have no relation to what comes out on the screen any more!
Speaking entirely qualitatively - it was suprising how easy it was to learn, and a few times since I abandoned it I've gone back and found that it can be picked up again within an hour or two once learnt (just like riding a bike?). And as a few other posters have already mentioned (for typing normal English) it feels more comfortable as less finger movement is required on average.
However (and this is the reason I've abandoned using it) - the dvorak layout is inappropriate for most uses apart from simply typing English - such as computer programming, working with spreadsheets, linux command line usage etc.
This is because by arranging the characters by their frequency in standard english, many non-alphanumeric characters which are rarely used in standard english but now very frequently used for other tasks on a computer are placed in very awkard positions requiring you to type with the little finger (or even worse, shift + little-finger). Here are some examples
':' - used a lot in C++, is where shift-'z' is on qwerty.
'{' and '}' - are shift-'-' and shift-'=' on qwerty.
'\'' and '"' - are q and shift-'q' on qwerty.