Comment Try this little program on WIndows 7 or 8 (Score 1) 195
It's called NegativeScreen and it's at http://arcanesanctum.net/negativescreen
It uses the graphics card to transform the colour space and has a number of different effects. Simple inversion works well even with Cleartype text and it sits in the notification area. Video works with it and it works across hibernate/sleep.