Comment MS Office, mostly (Score 1) 79
Of course, it would be nice if we could get a native version of Office 365. My needs are mostly covered with LibreOffice but I need sometime the real MS Office to test compatibility with some documents supplied by my clients.
Other than that, there are still some games that won't run on Linux, mostly because the kernel-level anticheat malware prevents that.
There's also some niche apps that only offer versions for Windows or Mac or Android/iPhone, but not for Linux. My digital signature with SignCloud has no app for Linux.