Comment Powershell (Score 3, Insightful) 427
Stay away from VBScript, its very out of date at this time.
Best work with Powershell, it has deep integration into Active Directory and Exchange (as well as OS, WMI etc). Its quite simple to get a script up and running, and its widely supported. It comes built into the OS in Windows 2008 onwards, for 2003 its available as a download.