Comment [Cleans glasses] Oh... (Score 1) 53
Amazon Finds 'Tokenmaxxing' Lacks Productivity Gain
[Picks back up copy of "Lord of the Rings".]
Comment Re:vi is the best editor (Score 1) 76
I don't mean to spoil emacs big day and all, and I'll let you guys talk about it
ctrl-x y
dammit
z w
y
wx
Hah. That bit made me think of this description of the TECO editor:
It has been observed that a TECO command sequence more closely resembles transmission line noise than readable text. One of the more entertaining games to play with TECO is to type your name in as a command line and try to guess what it does. Just about any possible typing error while talking with TECO will probably destroy your program, or even worse - introduce subtle and mysterious bugs in a once working subroutine.
P.S. I'm a long, long-time EMACS user (like since the mid 80s).
Fun note: Googling "emacs", gets you, "Did you mean: vim?" and Googling "vim" gets you, "Did you mean" emacs?"
Submission + - This frog bacterium wiped out cancer tumors in mice with a single dose (sciencedaily.com)
fahrbot-bot writes: Science Daily has reported that scientists at the Japan Advanced Institute of Science and Technology (JAIST) have identified a naturally occurring bacterium from the intestines of Japanese tree frogs (Dryophytes japonicus) that demonstrated remarkable anticancer activity in mice. The findings, published in Gut Microbes, introduce a new approach to cancer treatment that uses living bacteria to directly target tumors rather than simply altering the gut microbiome.
In a mouse model of colorectal cancer, a single intravenous dose of E. americana completely eliminated tumors, producing a 100% complete response (CR) rate. The researchers emphasize that these findings are limited to mice, but they believe the results provide an encouraging proof of concept for developing new bacterial cancer therapies.
First, E. americana directly attacks tumors. As a facultative anaerobic bacterium, it thrives in both oxygen rich and oxygen poor environments, allowing it to multiply inside the oxygen deprived regions commonly found within tumors. Once there, the bacterial population increased by roughly 3,000 fold within 24 hours after treatment, directly damaging cancer cells.
Second, the bacterium stimulates the immune system. Its presence attracted T cells, B cells, and neutrophils into tumors. These immune cells then released inflammatory signaling molecules, including TNF- and IFN-, which strengthened the immune response and promoted cancer cell death.
One of the most striking findings was that E. americana accumulated almost exclusively inside tumors and did not colonize healthy organs.
They found that the bacteria were rapidly cleared from the bloodstream, with a half life of approximately 1.2 hours, and became undetectable within 24 hours. No bacterial colonization was detected in healthy organs, including the liver, spleen, lungs, kidneys, or heart.
The treatment caused only mild, temporary inflammation that returned to normal within 72 hours. During a 60 day observation period, the researchers found no evidence of chronic toxicity.
In a mouse model of colorectal cancer, a single intravenous dose of E. americana completely eliminated tumors, producing a 100% complete response (CR) rate. The researchers emphasize that these findings are limited to mice, but they believe the results provide an encouraging proof of concept for developing new bacterial cancer therapies.
First, E. americana directly attacks tumors. As a facultative anaerobic bacterium, it thrives in both oxygen rich and oxygen poor environments, allowing it to multiply inside the oxygen deprived regions commonly found within tumors. Once there, the bacterial population increased by roughly 3,000 fold within 24 hours after treatment, directly damaging cancer cells.
Second, the bacterium stimulates the immune system. Its presence attracted T cells, B cells, and neutrophils into tumors. These immune cells then released inflammatory signaling molecules, including TNF- and IFN-, which strengthened the immune response and promoted cancer cell death.
One of the most striking findings was that E. americana accumulated almost exclusively inside tumors and did not colonize healthy organs.
They found that the bacteria were rapidly cleared from the bloodstream, with a half life of approximately 1.2 hours, and became undetectable within 24 hours. No bacterial colonization was detected in healthy organs, including the liver, spleen, lungs, kidneys, or heart.
The treatment caused only mild, temporary inflammation that returned to normal within 72 hours. During a 60 day observation period, the researchers found no evidence of chronic toxicity.
Comment Better PR this way. (Score 4, Funny) 65
Apple is replacing affected phones and investigating the problem.
They first tried telling people, "You're folding it wrong", but that didn't go over well.
Comment No problem now (Score 0) 36
he paid the ransom and charged victims a hefty fee on top.
This is the kind of crime that gets pardoned in this administration for a price. Ironically though, he'll pay some friend/member of the President a huge sum only to later find out the President got a much smaller amount for the pardon. Of course, *that* person will then get jailed for "stealing" money from Trump. (And I wish I was joking about all this
Comment More specifically ... (Score 2) 67
we recognize that not everyone will see their future here
We recognize that we don't see everyone having a future here. #FTFY
We have the talent, the creative firepower and the ambition to do it, and we will get there together."
But not with you.
Noting that if the "some people" offered voluntary buyouts don't accept them, they'll be part of the non-voluntary layoffs coming next and while the latter may be a better deal for some, you won't know if that's so until it's too late.
Comment Re:Well, that's a nonstarter (Score 2) 42
Systemd Rust components come out slightly larger than C with a test program being 32KB compared to 20KB for its C twin
Who's going to be able to scrounge up an extra 12KB of RAM in today's market?
Most things expand when they rust.
Comment Re:So, don't factor homework in the grade (Score 3, Insightful) 150
'No Point' Grading Homework
So, don't factor homework in the grade. Don't even collect it. Assign it of course. Design the tests to be challenging for someone who has done the homework. If students don't do the homework themselves and struggle and learn, they will fail the exam. Problem solved, the unfit won't progress.
My Calculus professor didn't assign any homework. On the first day of class, he simply handed out a double-sided sheet of paper packed with lists of problems from the textbook, which had the all the answers in the back, and said, "If you don't do every problem listed you probably won't pass the exams and class." I did every problem and the practice helped.
Comment In other words ... (Score 5, Insightful) 89
in business, intelligence is mostly judgment. Judgment depends on context, and the answer varies with which human or which model you ask.
Almost like having different kinds of people, with different backgrounds and experiences is helpful. Too bad that's unpopular at the moment.
Comment Re:Elite Sabotage Agency? (Score 4, Insightful) 42
Oh. Republicans.
And pretty sure "Elite" means something different after the DOGE purge
Comment Re:Finnish Wolves Finish Fled Villages (Score 2) 66
What I read from the paper is Google acted on its own assuming a certain (wrong) understanding of the law.
And Google possibly didn't care and thought if anyone complained it would be better for them to then ask for forgiveness than first ask and wait for permission, that they might not get. I hope they're fined *and* made to replace all the trees.
Comment You heard it here first (Score 1) 60
Palmer Luckey Reveals Genetically Modified Military Dog Startup
And... The company and/or product will be called "Luckey Dogs".
(A subsidiary of "Greased Palm(ers) Industries.)
Comment Within two years (Score 4, Insightful) 89
NASA is accelerating its Artemis program with an Apollo-era sense of urgency, aiming to return astronauts to the lunar surface in 2028 and establish a permanent base near the moon's south pole.
Sounds like Trump wants to put his name on something on the Moon
Comment Re:Lockdown by the TV manufacturers (Score 1) 101
will be the response to this. The manufacturers won't stand for it, because they lose the potential revenue.
Likely methods:
1. Proprietary Non-linux os's which have a smaller memory foot print.
2. Signed boot loaders with E-fuses blown in the microcomputer.
3. Potted CPU electronics.
4. TV hardware subscriptions (Now you don't own it) Click wrap contract provisions which prohibit modification of the hardware.
5. Mandatory network connections. TV won't work unless it is connected to the internet. This will allow security patches to stop jailbreaks and exploits.
6. Televisions legally required to always be on - like in the dystopian future of Max Headroom.
Comment Re:normal matter decay produces antimatter? (Score 2) 48
I'm curious how the nuclear decay of sodium 22 produces antimatter to begin with. Does something transmute, for lack of a better word, into antimatter when its nuclear bonds are broken?
Bananas create anti matter. From Ten things you might not know about antimatter (also mentioned, but not explained here DOE Explains...Antimatter)
Bananas produce antimatter, releasing one positron—the antimatter equivalent of an electron—about every 75 minutes. This occurs because bananas contain a small amount of potassium-40, a naturally occurring isotope of potassium. As potassium-40 decays, it occasionally spits out a positron in the process.
