Comment Why is this antivenom different from others? (Score 3, Interesting) 27
The magic is that three antibodies confer protection against many species of snake. But why doesn't this happen for existing antivenoms? From the ABC article:
antivenom is created using animal blood, like horses or other large mammals.
The animals are given small doses of the venom, and then over time given larger and larger doses. This helps the animal produce an increasing immune response without getting so sick they die.
From another article:
Broad-spectrum or “polyvalent” antivenoms are made by injecting horses with mixtures of venom from different species or different populations of snakes. However, the elevated antibody content per dose can increase the risk of adverse reactions.
It's not surprising that cells developed in a human are more suited to us than cells developed in horses. But the technique is fundamentally the same. Is the new antivenom better solely because it is human, or is it somehow more adapted as a result of being honed in vivo for 18 years?