Content VS layout (Score 1)

The most important element I would consider to be content. The data one is trying to get across is critical. What is the site selling, or what ideas is it trying to put across? Given the radical difference across the board of different CPU speeds, monitors, capabilities (eg Links/Lynx and text based browsing VS NS/IE[456]) multiple versions of a site designed for the optimum experience on a particular system would be the ideal. This would be where templated frameworks such as AWF (Active Web Framework) come in useful. Fast, cacheable data and the ability for different templates to generate Dynamic HTML or static content as needed is likely to produce the best result in most circumstances. On the other hand, some sites are designed with the eye-candy content being the more important factor, such as theme sites for Movies, fan sites etc. The target audience would determine which of these 2 approaches to take.