When did regulate ever mean "to make regular". The word "regulate" comes from the Latin "regula" which means "to rule", and even as early as Middle English, meant "to direct, to make rules". You're just inventing a fake etymology to further a false argument about what the framers of the Constitution intended.
"Regulate" meant the same in 18th century English as it does today.
"regulate (v.) Look up regulate at Dictionary.com
early 15c., "adjust by rule, control," from Late Latin regulatus, past participle of regulare "to control by rule, direct," from Latin regula "rule" (see regular). Meaning "to govern by restriction" is from 1620s. Related: Regulated; regulating."