I just love these people who declare were almost done with things. Rutherford told the Physics community "stop training students...all we have to figure out is this electron thing and were done" (to paraphrase). Then along came Quantum Mechanics and Relitivity and suddenly there was a job to do and nearly 100 years later were still working on those two next big things. Astronomy did simillarly with cosmology ("if we can just get omega up to 1.0 then we understand it all"). Now its Computer Science's turn to be just about finished....
The point is the next big thing is not something you ever plan for. It happens. Did ARPA know their net was going to change the way we do business? No. Will something else come along and change the way we work, live, and exist? Yes, because it always does.
Now go turn your crystal balls into magic 8 balls. They are more reliable that way.