Elsevier (RELX) costs around $30B total, so perhaps not. Better would be to very publicly and repeatedly proclaim that the era of closed scientific publications is over, then over a decade or so push down the value until controlling stake can be had for peanuts (relative). After that they can put it all public unless someone else has taken the step in the mean time.

Many older games are still extremely good, despite dated graphics and more difficult game play compared to modern creations. I suggest checking out adventuregamers.com if you like Grim Fandango, Syberia, etc: http://www.adventuregamers.com/reviews.php reviews -> all -> sort by ratings Most of the highly rated games are very nice indeed. Some can be difficult to find. Ebay/amaazon/etc may have some, gog.com or such may have others, or your friendly neighbourhood p2p archive probably have most of the rest. Telltale games and some other companies do create good modern adventure games as well. Playing together with others also makes it more fun. My wife and I usually play together, and old adventure games are our staple fare. Coop games can be good, but much more difficult to find. Some old RPG games like Baldur's Gate and Neverwinter Nights are good coop, as well as some more modern arcade games like shadowgrounds and alien swarm. Then there are the MMOs and regular multiplayer, but we have not found any that we both like yet. The good immersive games are few and far between, but looking through forums and fan sites can help find the true gems, whether it is an adventure game that carries you to another world for days, a simulator or fps that is good for a couple of hours, or an arcade that leeches 15min of focus every now and then. List the stuff you really liked then start searching using some of them as search terms.

Genes mainly contain information on how the initial stage of protein construction should go. Protein design, engineering, improvement is not new. We have improved upon quite a few proteins, shooting for better functionality in one area or other, and that is done by "improving" the genetic code in one way or other.

The immune system is only partially responsible for weeding out those nasty malfunctioning cells. Many other systems kick in. Mainly in the cell itself, programmed cell death - apoptosis - is triggered from a multitude malfunctioning cell states, as well as from various well functioning states internal and external to the cell itself. Malfunctioning cells generally have to be seriously malfunctioning, and express a "non-self" surface biochemistry before the immune system kicks in and starts attacking it.

The independence war series is very interesting for more "reality" in the space battles. And a lot of fun to play.
http://en.wikipedia.org/wiki/I-War_(Independence_War)
http://en.wikipedia.org/wiki/Edge_of_Chaos

I spent quite a few hours on I-War, Defiance, and Edge of Chaos, and they certianly take some training to get good at. Before those there was only the old amiga game "Warhead".
http://en.wikipedia.org/wiki/Warhead_(computer_game)

Of course I also enjoy Descent, Freespace, Tie Fighter, etc. But more for the general feeling or dogfighting, not very "realistic", just fun game systems. Even EVE is a lot of fun to play, but it has nothing to do with space battle. It is just EVE battle, i.e. coordination, logistics, social management, etc.

The greater LA region is still minor compared to the greater Tokyo region, population, economy, etc. The cultural choice is what makes LA difficult without a car. The Tokyo mass transit system is in my experience the best in the world, and it really works amazingly well. http://en.wikipedia.org/wiki/Greater_Los_Angeles_Area http://en.wikipedia.org/wiki/Tokyo

Is this something like what you are looking for?
http://www.adesso.us/product_details.asp?dept_id=106&pf_id=KA33PCK-308UB