All of these drugs have severe mind-altering side effects. Memory loss sometime permanent is a frequent complaint. Dulling of emotions another. Of course, along with all the dulling, the bad thoughts are also dulled and thus the effectiveness. The drugs make you less human so that you can live with the fact that being human is a tough sordid ordeal. Hell, being alive is a tough sordid ordeal. It's just that since we are sentient, we question everything and that causes the root problem. I think that if depression is caught early and diet and exercise is introduced, it can be prevented from becoming life-consuming but it is not recognized early enough and it becomes severe, there is no times for games, the drugs are then needed to prevent a much worse outcome.