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Comment Re:I don't want cas13 in my body (Score 1) 37

"Only infected cells receive the CAS13-generating RNA."

That's probably not true. I haven't read the paper (is there one?), but I would be surprised, actually shocked, if they had a reliable/efficient way to ensure both high transfection efficiency and that only infected cells receive the cas13-generating RNA. It's far more likely that they targeted the cell type that gets infected with influenza. That would be the more efficient and currently best method. The way the treatment works is that the cas13 has to be triggered by the presence of viral RNA. Without viral RNA that corresponds to the code the cas13 was programmed with, the cas13 does nothing and degrades eventually.

Comment Criticism valid and invalid (Score 2, Informative) 37

“I like the idea of it, but it’s putting a foreign protein from a bacteria into someone’s body,” he says. “So will the body make an immune response against it?”

Yes, in the current implementation, it most likely will. This is not only because the protein is of bacterial origin, but also because it did not originate from the patient's own proteome and was therefore never subject to immune tolerance. What will first happen is a process that eventually affects nearly every protein in a cell, whether they're good or bad: the Cas13 is broken down into fragments and displayed on the cell's surface. This mechanism is known as the MHC-I antigen presentation system. Once these Cas13 fragments are displayed, the immune system recognizes the cell as compromised or foreign and destroys it.

However, there are solutions to this. For example, one could introduce a molecule like CD47 (among others) alongside the Cas13, which acts like a Jedi mind trick on the immune system. These molecules essentially signal the immune system to ignore any foreign antigens displayed on that cell's surface.

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"Heaton also cautions against “off-target effects,” the chance that a Crispr treatment will inadvertently go after your body’s own RNA as well as an invading virus."

Uh, no it won't on a scale that matters. As for will it destroy the RNA of the infected cell and cause it to die? Probably yes (note: there's a way to prevent that), which may be a good thing.

Comment Re: Truck drivers will still be required (Score 1) 175

There are a ton of ways to cheaply solve this last mile problem -- such as trucks stopping in a designated spot (parking lot? gas station?) where a contracted human gets on it to babysit the last mile and argue with the foreman. They may not even need a CDL .. just some training on using the truck's touchscreen interface.

Will there be certain locations that are edge cases? Probably. The semi has room for a person, so those can be handled .. until the edge case scenarios have an automated truck handling and control system.

Comment Impressive (Score 1) 175

If 1.2 is the peak, I speculate (disclaimer, I don't know any shit about it) they would probably limit it to 1 MW due to safety factor and things like that. Even 1 MW is very cool. Now if they finalize autonomous driving (China already has https://www.youtube.com/shorts... ) and autonomous charging .. truck driving jobs will be like vacation.

Comment That's a lot (Score 1) 57

Manufacturing cost is probably $2K or less. So that means they are getting $100 million profit a quarter that they can put into the R&D team. They probably have 500 people working on R&D, which is a lot. As far as hardware, recall .. they don't have to design the chip, and the board is probably the same or very similar to what the MacBook Pro team designed. They need some people to work on modelling/managing device heat flow. The biggest expense is probably the optics team and the display evaluation team. Also the sensor and display teams that works with hardware vendors to find out & test what oled display can be purchased at what price. My point -- 200 people just on hardware design is probably plenty. I mean Bigscreen Beyond makes better VR headsets and they are two guys in a garage as far as I can tell.

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