There's certainly a strong brain & immune component as an appetite suppressant.

https://www.cell.com/cell-meta...

Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation

Summary
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) exert anti-inflammatory effects relevant to the chronic complications of type 2 diabetes. Although GLP-1RAs attenuate T cell-mediated gut and systemic inflammation directly through the gut intraepithelial lymphocyte GLP-1R, how GLP-1RAs inhibit systemic inflammation in the absence of widespread immune expression of the GLP-1R remains uncertain. Here, we show that GLP-1R activation attenuates the induction of plasma tumor necrosis factor alpha (TNF-) by multiple Toll-like receptor agonists. These actions are not mediated by hematopoietic or endothelial GLP-1Rs but require central neuronal GLP-1Rs. In a cecal slurry model of polymicrobial sepsis, GLP-1RAs similarly require neuronal GLP-1Rs to attenuate detrimental responses associated with sepsis, including sickness, hypothermia, systemic inflammation, and lung injury. Mechanistically, GLP-1R activation leads to reduced TNF- via 1-adrenergic, -opioid, and -opioid receptor signaling. These data extend emerging concepts of brain-immune networks and posit a new gut-brain GLP-1R axis for suppression of peripheral inflammation.

> GLP-1 slows digestion and retains food in the stomach. That MAY alter your appetite, but it may not.

The effect on the digestion is a less than desirable side effect. There's research to make variants which work only in the brain and less in the gut, which would be more tolerable.

2014:

Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weight

https://pmc.ncbi.nlm.nih.gov/a...

The peptide hormone glucagon-like peptide-1 (GLP-1) enhances glucose-induced insulin secretion and inhibits both gastric emptying and glucagon secretion. GLP-1 receptor (GLP-1R) agonists control glycemia via glucose-dependent mechanisms of action and promote weight loss in obese and diabetic individuals. Nevertheless, the mechanisms and cellular targets transducing the weight loss effects remain unclear. Two recent studies in the JCI provide insight into the neurons responsible for this effect. Sisley et al. reveal that GLP-1R agonist–induced weight loss requires GLP-1Rs in the CNS, while Secher et al. reveal that a small peptide GLP-1R agonist penetrates the brain and activates a subset of GLP-1R–expressing neurons in the arcuate nucleus to produce weight loss. Together, these two studies elucidate pathways that inform strategies coupling GLP-1R signaling to control of body weight in patients with diabetes or obesity.

It's not just manifold geometry that makes the difference, though.

The biggest difference is in having a real parametric history. You can mimic a lot of this in blender by stacking modifiers, but at a certain point, you end up needing to apply the modifiers (eg. to make a single edge of a boolean "real" so that you can apply a fillet, for example)

If you later need to make a modification, any of the actions that happened before you applied the modifier stack are now lost. With certain edits you might be completely stuck because there's no way to adjust that particular element without either having to manually retopologize the entire model, or cutting large sections of the model away and rebuilding it.

But, in a parametric CAD, you just go to the step in the history and change your parameters. All subsequent steps recalculate. (When it works, that is. It's still possible to break things this way too. No system is perfect.)

This doesn't make blender bad. It's fantastic, it's just not designed primarily as a precision CAD modeler. Conversely, I wouldn't try doing character animation in a CAD app. Some tools are just optimized for certain workflows.

Unless you're the type of person that can't make it 35 seconds into a show without 'splosions or some ludicrously choreographed martial arts sequence ... I've never understood the "starts slow" characterization of Breaking Bad.

I get that label a little more for the Better Call Saul spinoff, but even there, the character writing was deep and good, so it made up for the less "wacky adventure" nature of the first couple seasons.

I've done design work using OnShape (browser-based CAD) on a Chromebook just fine.

I doubt it would hold up to complex assemblies, but creating basic parts for 3D printing was totally doable.

People are going to learn better if there is some applicability outside the classroom. Nobody is writing anything in Racket outside of their homework assignments.

But, if you pick a language (any language) that students can use to do actual things, they'll be more likely to do more than just learn enough to complete the assignment. I learned more from poking around in BASIC (as bad as it is) on Atari and Commodore computers than I learned in college programming classes, simply because I had to keep expanding knowledge to do new things, whereas the college assignments I only needed to do enough to be graded. (And I've never touched Modula-2 outside the classroom.)

I'm not a big python fan, but at least people can actually use it outside the class, as many applications use it as their built-in scripting language (eg. Blender, FreeCAD, etc) and there's even applicability to hardware (MicroPython, CircuitPython) which cna bridge to other CS-related tasks as people can mess with inexpensive microcontrollers.

Of course, you can do all this with C, as well, but a higher level language is typically an easier thing to understand for people that haven't ever programmed before.

Have you seen the show?

Because (spoiler alert) by the end, it pretty much ruined the life of everyone who was involved, or even knew someone who was.

The previous poster is correct. And semaglutide alters signaling which was damaged or ineffective.

And I'm 100% for it. Lots of diseases have improper signaling and altering energy metabolism is probably clinically risky. The hunger signaling is so deep in evolutionary history it's not possible to override in practice. Changing the setting also is safest--hunger signals are still there with their normal function just lowered in intensity.

People with the problem feel like they are eating 1200 calories even though they aren't. That's a big problem that deserves to be fixed.

> So this all seams horrible but maybe we should ask some philosophical questions about how wrong it really is to offer healthy-bmi-the-easy-way as a subscription.

About as wrong as offering the healthy-blood-pressure-the-easy-way as a subscription. Or clean-water-on-top as a subscription.

And in truth, the collection of BP medications has saved many people from nasty diseases and poor health.

> In some people, all calories are stored as fat regardless of how little they eat.

That can't happen because there's continuous energy consumption from something. That the hunger signals are wrong and misguided in some people is a certainty though.

> two people eating the same diet may not experience the same changes to their body's mass.

thats the calories out

> All you'll do is make yourself addicted, dependent on expensive weight loss shots to make you feel a little bit better.

Does that apply to cholesterol and high blood pressure medications?

Realistically, they are much more efficacious than lifestyle changes, and most people have few serious side effects and it stacks upon personal behavior changes.

And healthy eating is much much easier according to those who are on the GLP-1As. Hunger drives are obviously strongly evolutionarily embedded to the beginning of life.

And the new class of drugs (unlike previous generations) are showing clear clinical benefit to heart diseases, liver, kidneys and reduce chance of Alzheimers. It's pretty remarkable and I'd feel a fuckload better not having a heart attack if I had a problem. I'm opposed to such sort of sneering moralizing bullshit like "All you'll do is make yourself addicted, dependent on expensive weight loss shots to make you feel a little bit better."

I'm addicted to indoor plumbing and safe water treatment to reduce infections and illness. I'm 100% pro civilization. GLP1As, like blood pressure meds, are part of the deal.

Reusing the orbital craft is much more difficult to do economically than the booster. It re-enters far faster with much more damage---or would take much more fuel to slow down, severely reducing paying payload.

I suspect SpaceX may go to an expendable upper stage (light and with higher capacity as it doesn't need to survive coming back) for numerous missions, particularly those which need extra orbital energy.

There was the beginning of scientific computing using GPUs, CUDA was under development and the trend towards general purpose two-way computation was starting.

That 23% was likely not curtailed, a large amount was probably exported.

The curtailment of wind and solar is pretty low now with the large amount of battery capacity.

Batteries in CAISO went from 500 MW in 2020 to about 11,000 in 2024. Yes, that's power and not energy, but most are sized at 4 hours.

https://www.caiso.com/document...