Submission + - Scientists Built Cancer Kill Switch That Turns On With Flash of Light (studyfinds.com)
fjo3 writes: Cancer has a dirty trick: it can put itself to sleep. When tumor cells slip into a kind of biological hibernation, they become hard to kill, shrugging off treatment and lying low until conditions improve, then waking up and bringing the disease back. For decades, researchers have struggled to shut down this hiding strategy without causing serious harm elsewhere in the body. A team in Switzerland has now built a molecule that flips on and off with flashes of light, giving scientists a precise new way to probe, and possibly disrupt, the way sleeping cancer cells hide.
Behind this cellular sleep state, at least in certain cancers, sits a protein called the glucocorticoid receptor, a sensor inside cells that reacts to stress hormones. When it switches on, it can push cancer cells, especially in some solid tumors such as lung cancer, into a drug-resistant, dormant state. The obvious fix would be to destroy the receptor outright, but there is a catch: the same receptor does important jobs all over the body, including calming inflammation. Removing it everywhere would cause real damage. What was needed was a way to hit the receptor inside a tumor and leave the rest of the body alone.
Behind this cellular sleep state, at least in certain cancers, sits a protein called the glucocorticoid receptor, a sensor inside cells that reacts to stress hormones. When it switches on, it can push cancer cells, especially in some solid tumors such as lung cancer, into a drug-resistant, dormant state. The obvious fix would be to destroy the receptor outright, but there is a catch: the same receptor does important jobs all over the body, including calming inflammation. Removing it everywhere would cause real damage. What was needed was a way to hit the receptor inside a tumor and leave the rest of the body alone.