Why wouldn't it be answerable? These drugs have all been tested against placebo, so if there's not an actual difference in natural production or sensitivity, then the only remaining avenue for these drugs to work is that fat people *are* nothing but weak-willed and lazy, and need an essential overdose to act "normally." Seems like you could easily measure serum levels of GLP-1 and GIP, to start with, but why would you? Just to make the people who take the drugs successfully feel bad about themselves? What would the point of that research be? Nobody's trying to work out how much pain you're *really* feeling before they decide whether it was okay that you took some ibuprofen. It'd be just as easy to say "ibuprofen doesn't address the underlying problem that you're a crybaby."

There's not one of these drugs that "just slightly increas(es) the supply of naturally-created compounds." They are absolutely not to be found in the unmedicated human body- they are agonists, meaning they find to the cell receptors that the naturally-occurring hormone does. Though I don't know these current drug molecules' origins, I do know the research started with gila monster venom.

How else are you going to address a root cause if it's an outsize compulsion to eat?

I mean, I know nothing about your weight, but could you quantify for me how much mental effort is necessary to maintain that weight so that I can judge you? Judge you more accurately, that is.

You should probably consider that the interest rate that has you freaking out isn't that far from market returns of late. Perhaps he doesn't want to lose a year of making 17% on the cost of his vacation just to avoid the possibility of paying 19% for a couple months when it turns out he can actually go.

I don't like paying people interest, either, but I also don't like making no money on my money, or converting my anticipated stepped-up $0 taxes to short term capital gains at 32%, or discovering I've got to pay interest and penalties on that tax to boot, or any number of other things that can make 20% credit card interest rates look like a bargain.

If Robert Bigelow, an actual hotelier, couldn't get people vacationing in space with his aerospace company, I don't know why I'd expect these guys to be able to.

Your homemade pizza can't hold a candle to the shops you left behind. That you don't admit this is baffling. Your oven isn't hot enough, and it's not brick enough. Your dough isn't glutenizing enough, nor has it rested enough.

Yes, it is possible to address all of these things. In a commercial pizzeria, not the typical home kitchen with dinner started at 6pm.

I have started to just make my own pizza, which is a lot cheaper and quite a bit better.

Sure, buddy. Sounds like you should go open a place and join the others going under when your hubris catches up to reality.

It is simply not possible to make a high-quality New York, Neapolitan, Greek, or St. Louis style pizza in a home kitchen. I'm willing to bet the same is true for Chicago, Detroit, or Sicilian style pizzas as well, though I can't claim decades of trying myself for those.

Why not? Because we know that we could be made whole with a 2.05% (or in some cases a 4.6%) interest rate reduction, yet we haven't even asked, let alone figured out, whether any appreciable number of borrowers experiencing difficulty would have it in hand or even already paid the loan off with that reduction.

Don't think 2.05% makes that much a difference? Then why would the President be complaining about interest rates?

Trademark law does protect Fleischer against that risk.

Maybe, at best. If the use on backpacks, etc., is merely ornamental use and not considered by a court to show secondary source, it absolutely does not protect them. Courts have been a bit all over the map on this, and there's not a particularly definitive case, so the correct observation to make is that it's yet another grey area.

And you ask why people might read print magazines. Feel free to give up after one online-only article.

They're publishing higher-quality materials online than are making it to print? (They aren't.) You also mentioned a subject in "the arts," though I will note the New Yorker's coverage of that book from six weeks earlier was considerably more enlightening. Do people try to read long form journalism on devices and still get the details and full import of the story?

It's fine to disagree, just don't be so dismissive.

Not the New Yorker? I'd say the publication schedule gives it a clear advantage over the Atlantic (f.k.a. "Atlantic Monthly"). That also translates to some quantity advantage, of course.

The automatic renewal of copyright registrations was done in 1992, well before the 1998 Sonny Bono extensions of term. That 1992 act pertained only to registrations between 1964 and 1977- all others were either already renewed, already non-renewed, or not subject to a renewal requirement.

Ah, the Donald Trump Zeno's Paradox: you list all the lies, taking you into next week, so then you list all of that week's lies, taking you three and a half days...

The government IS the lender. Try to keep up