So, when we say microplastics, we really mainly mean nanoplastics - the stuff made from, say, drinking hot liquids from low-melting-point plastic containers. And yeah, they very much look like a problem. The strongest evidence is for cardiovascular disease. The 2024 NEJM study for example found that for patients with above-threshold levels of nanoplastics in cartoid artery plaque were 4,5x more likely to suffer from a heart attack. Neurologically, they cross the brain-blood barrier (and quite quickly). A 2023 study found that they cause alpha-synuclein to misfold and clump together, a halmark of Parkinsons and various kinds of dementia. broadly, they're associated with oxidative stress, neuroinflammation, protein aggregation, and neurotransmitter alterations. Oxidative stress is due to cells struggling to break down nanoplastics in them. They're also associated with immunotoxicity, inflammatory bowel disease, and reproductive dysfunction, including elevating inflammatory markers, impairing sperm quality, and modulating the tumor microenvironment. With respect to reproduction, they're also associated with epigenetic dysregulation, which can lead to heritable changes.

And here's one of the things that get me - and let me briefly switch to a different topic before looping back. All over, there's a rush to ban polycarbonate due to concerns over a degradation product (bisphenol-A), because it's (very weakly) estrogenic. But typical effective estrogenic activity from typical levels of bisphenol-A are orders of magnitude lower than that of phytoestrogens in food and supplements; bisphenol-A is just too rare to exert much impact. Phytoestrogens have way better PR than bisphenol-A, and people spend money buying products specifically to consume more of them. Some arguments against bisphenol-A focus on what type of estrogenic activity it can promote (more proliferative activity), but that falls apart given that different phytoestrogens span the whole gamut of types of activation. Earlier research arguing for an association with estrogen-linked cancer seems to have fallen apart in more recent studies. It does seem associated with PCOS, but it's hard to describe it as a causal association, because PCOS is associated with all sorts of things, including diet (which could change the exposure rate vs. non-PCOS populations) and significant hormonal changes (which could change the clearance rate of bisphenol-A vs. non-PCOS populations). In short, bisphenol-A from polycarbonate is not without concern, but the concern level seems like it should be much lower than with nanoplastics.

Why bring this up? Because polycarbonate is a low-nanoplastic-emitting material. It is a quite resilient, heat tolerant plastic, and thus - being much further from its glass transition temperature - is not particularly prone to shedding nanoplastics. By contrast, its replacements - polyethylene, polypropylene, polyethylene terephthate, etc - are highly associated with nanoplastic release, particularly with hot liquids. So by banning polycarbonate, we increase our exposure to nanoplastics, which are much better associated with actual harms. And unlike bisphenol-A, which is rapidly eliminated from the body, nanoplastics persist. You can't get rid of them. If some big harm is discovered with bisphenol-A that suddenly makes the risk picture seem much bigger than with nanoplastics, we can then just stop using it, and any further harm is gone. But we can't do that with nanoplastics.

People seriously need to think more about substitution risks when banning products. The EU in particular is bad about not considering it. Like, banning neonicotinoids and causing their replacement by organophosphates, etc isn't exactly some giant win. Whether it's a benefit to pollinators at all is very much up in the air, while it's almost certain that the substitution is more harmful for mammals such as ourselves (neonicotinoids have very low mammalian toxicity, unlike e.g. organophosphates, which are closely related to nerve agents).

Thanks for making my point for me there bro

I'm going to go ahead and assume bad faith on your part, because otherwise you're very stupid. But nobody in your potential audience is stupid enough to believe there aren't lasting effects to being bombed to shit.

I take your point about this being before the dawn of ubiquitous tech companies, but what kind of chilling effect did the Bell monopoly have?

Do you think about me when you're jerking off, too? I know you do.

It would take an AI to not get bored trying to construct working configs for SElinux

Perhaps you did not buy a Tesla. They are probably the most service-hostile vehicle ever sold in the US. Not sure about the UK, I haven't heard stories (horror or otherwise) about service for Chinese EVs yet. They would have to try really hard to be worse than Tesla, though.

Google xkcd extrapolate

s/best/only/

No, I remember owning a calculator watch with phone directory because I could never remember phone numbers, outside of a few I used all the time. Then I got a cellphone and now I don't need to wear a watch.

Simp harder

With three wheels? No doubt they will, insert clip of Reliant Robins here :D

Yeah, you're a rebel for adopting software pushed into the freest OS by a Microsoft agent.

Age verification is not what is being discussed, and only an incredibly simple person who is completely unable to imagine ramifications of what is obviously ubiquitous identity verification would make such a drastic mistake. This kind of technology is an obvious component of "sending the military into [our] cities" and "destroying [our] way of life" and is in fact exactly what the followers of the orange piggy are promoting. Did you not notice what's going on with e.g. flock? Fucking wake up and learn to pay attention, fascism enabler.

Thank you, from the bottom of my heart, for proving that you know absolutely nothing about the subject we are discussing. It is so convenient when know-nothings out themselves I cannot properly express my appreciation.