It says it on the box. The system requirements are there. I'm not sure why people complain about the game not working on their platform. If you want to run it, just run a full blown VM and call it a day. Virtual Box is free. That being said I'm using an OS X virtual machine and it runs very well with D3 thanks to a few tweaks.
Running a full blown VM this day and age is not a difficult thing for a hacker to do, and even better, is still as cheap as running WINE if you have a copy of OS X "laying" around.
The system requirements are printed on the box, its their code, and people not reading the TOS leads to this. If you really want to stick to the OSS mantra - this piece of closed source code should not even have touched your system anyway.