In my case, I consider a numpad-less keyboard is an optimal design. I detest number pads (and caps-lock keys but that's a whole other story) with a burning passion. Way back when, that's why I bought a Happy Hacker keyboard (PS2 interface, sadly). The gap between the keyboard and the mouse is annoying and physically bad for your body (though it may be fine for left-handed mouse users?). For same number of folks that do number crunching enough to actually need a numpad more than they need comfortable text typing, I wish the market would make standalone usb numpads more popular. They're ideal: pull one out when you're number crunching, puss it back when you're not.
"If you want to eat hippopatomus, you've got to pay the freight." -- attributed to an IBM guy, about why IBM software uses so much memory