Very Old Story (Score 1)

Though undoubtedly Titan A.E. draws from a wealth of contemporary sources (Star Wars, Tron, etc.), its most significant influence is quite ancient: the Hebrew Bible. Specifically, the story is a retelling of the Messiah tales embeded in the prophetic books of Jeremiah and Isaiah. In the prophetic books, the Messiah was conceptualized not so much as a spiritual or mystical figure, but as a political hero who would restore national sovereignty to the Israelite nation following the Babylonian Exile of 586 B.C.E. The movie and the books of the prophets are closely parallel, e.g.:

The Kingdom of Israel (Earth) is threatened by the "alien" Babylonians (the Drej); the destruction of the Temple by the Babylonians (the destruction of Earth by the Drej) leads to the exile and Diaspora of the Israelites (the scattering of humans across the galaxy). An unlikely hero descended from the builder of the Temple (Cale) becomes the Messianic savior of the Israelites by participating in the miraculous rebuilding of the Temple and the ingathering of the exiled Israelites from all corners of the world to the promised land (I'm sure you can see the rest of the parallels).

Of course, Titan A.E. isn't meant to be an especially religious story; it's just important to remember when we complain about how one movie draws heavily from another, that almost every story at its core draws from the themes elaborated in the canons of Western civilization.