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Comment What is the performance? (Score 2) 49

In a Claude Science demo, Oliver Vince, PhD, co-founder at Basecamp, uploaded a sample patient microbiology report. When given a simple natural language prompt, the platform designed peptides, predicted their efficacy, and provided a shortlist of candidates most likely to succeed in experiments in minutes.

This is a meaningless statement. I too can create a tool to generate a list of peptide candidates with minimal effort. It may even be somewhat useful if it based peptide sequences on homology searches or some other relevant biology instead of random string generation. This has been an active area of research for than 20 years. In order for this to be newsworthy. Claude has to be better than what already exists. How many novel candidates does it generate that actually have useful antibiotic properties? Do I have to screen through a list of 100 candidates to find one that actually works? If so, that’s not much better than a BLAST search and it costs a lot more. What is the strain selectivity of the new antibiotic? Is it broad or narrow spectrum? How easy is it to manufacture? Are there any toxic side effects?

Assuming a new antibiotic is actually what’s needed, instead of using one of the many beta-lactams or combination therapies that already exist, generating the candidate is the first and easiest step of a long and expensive process to developing a novel drug.

Comment Re:Read the Legislative Analysis (Score 1) 19

The committee analysis greatly exaggerates the requirements, but the objections are still at least somewhat valid. If a company (imagine a developer-owner, one-man show) stops hosting the only live server for a game because he's taking care of an ill spouse, why should he be obligated to make significant software modifications, host those patches, or create documentation instructing how to create and host a the game via a private server. And if he doesn't do so, then he has to refund everyone at the HIGHEST PRICE for which the game has sold in the last 12 months?

It should be fairly easy to carve out provisions for exceptional circumstances (ex: bankruptcy proceedings), and is probably common practice already. But I agree the language has an implied target which is not good for getting legislation passed, generally. It should be possible to propose reasonable accommodation for majority circumstances without sounding like a manifesto.

A BETTER bill would have been simple: "The IP-holder of a video game that ceases distribution/hosting ALSO relinquishes both liability and control over software replication and hosting."

That will run into problems with federal copyright laws and other IP protections. While it sounds just, it is unlikely to get anywhere. More likely is large companies would have to have an end-of-life plan for their product (which they likely do already) that includes considerations for how to keep the game playable after servers are taken offline. It could be as simple as releasing the protocol to enable third parties to host servers. Or, better, designing the game for offline play from the beginning so that the final patch set is just a simple switch.

Regardless of the outcome, however, this really does seem like a pre-eminent example of “first world problems”.

Comment Re:Hype (Score 1) 27

Well, it says in the abstract (and they have further detailed calculations in the paper) that they achieved an average desalination rate of 1.76 kg/m^2/h. So that’s about 1 gallon of water in one hour with 2 m^2 panel. That said, they did their tests using a 9 cm^2 panel, so yields may change significantly on scale up. Not sure if that translates into meaningful cost savings at scale, but it does seem like a significant advance in solar desalination technology. It seems like the paper was focused mostly on salt harvesting, though, rather than desalination. So I expect the real utility to be the combination of the two rather than desalination by itself, if it scales.

Comment Dumped Grok over this (Score -1) 72

Grok was constantly say it was doing something that it had ZERO ability to, and I kept calling it out and it kept apologizing and then immediately doing it again.

As a guy who spend 5 figures a year on Ai, the last thing I want is that. I know Claude and ChatGPT also do it, but Grok was doing it CONSTANTLY.

Comment REGULATION: the world's worst thing ever (Score -1) 77

Regulators should be afraid of weaponized Ai. So should censors. So should monopolists.

All of the things the State has done in the past 500 years has been corrupt and bureaucratic and caused harm. All. Not most, but all.

All of the people who supported it, from monopolists to lobbyists to activists caused harm.

Ai is undoing it all. Not piece by piece but all at once.

I, for one, can't wait to see folks zapped for restraining voluntary behavior.

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