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Comment Re:But not in the US (Score 4, Insightful) 228

In fact, it is UNETHICAL to use a placebo control in any clinical trial of an investigational product for which the existing standard of care already includes a product on the market.

In plain English, it is entirely unethical to give participants a placebo to test the efficacy of a new flu vaccine when we already have existing vaccines on the market. Doing so denies participants in the study from accessing effective treatment. If you have to test against a placebo, it will be impossible to recruit participants, because nobody will take the chance to receive placebo when they could just go to the pharmacy and get vaccinated.

There are only two possible explanations for such a position: either gross ignorance of basic scientific and ethical principles for conducting medical research in humans, or deliberate malicious intent to stop all research of investigational drugs. It doesn't actually matter which one is the reason. Both are entirely unacceptable.

The fact that a huge segment of the American population does not understand even the most basic scientific principles is the reason why many people will die needlessly.

Comment Re:Sums up the housing crisis (Score -1) 102

This is such cry-baby nonsense.

NONSENSE.

Since 2008, I have personally mentored dozens of young dudes (at no cost whatsoever, just because that's what successful people do).

I have helped poor dudes in bad neighborhoods buck up, get some side hustles, stack cash, and buy property.

You fucked yourself because you refuse to actually do someone to buy property. I don't know ANYONE, starting with even zero money, who couldn't find a nice home in just 2-3 years of saving money properly -- except the lepers in California, and fuck them anyway.

Comment Re:Off Insulin onto immunosuppressants for life... (Score 4, Informative) 65

I agree that this therapy is not without significant risks, so it's not to be taken lightly.

That said, the long-term health outcomes of T1DM are also significant. So the way I see this development is that it is one more step on the path toward finding a durable, safe, and effective cure. And if approved, it may offer some patients another choice, one that of course should involve an informed discussion with competent healthcare providers.

It's important to keep in mind that healthcare is not a "one size fits all" thing. Two patients that have the same condition can respond very differently to the same therapy. Before the discovery of insulin, diabetics literally just...died. So on the path to understanding this relationship between the individual patient and the selected therapy, medical science can only offer a range of treatment options. At one time, humans believed in bloodletting, lobotomies, and arsenic to treat various illnesses. We built leper colonies. And in some places in the world, menstruation is still considered "dirty." We have made many advances, but there are still many more to be discovered.

Comment Re: I know people who use Twitter (Score -1, Flamebait) 73

I would rather let Nazis speak and elect to block them myself than have an entire moderation team block everyone they disagree with.

Reddit is equally a shithole.

Heck. /. used to have a good libertarian minority and today it's nerds defending their trans kids here.

Comment Re:I'm Still Not Seeing It (Score -1) 36

I don't own a computer. I am not a programmer. I do everything from my iPhone.

In the past 10 years, I have spent tens of thousands of dollars on human programmers to create 3 web apps. Zero of them ever were finished. ZERO.

I used Grok AI to create 5 web apps. 3 of them were monetized almost immediately and have paying clients. All 5 have passed security checks that look for bugs or hack entry points.

One of the 3 monetized web apps took me all of 30 minutes using Grok, on an airplane, using my iPhone. I was able to download the files and upload them to a web server and the site was live. Literally 30 minutes and that website has created thousands of dollars of passive income.

I use vibe coding DAILY to make spreadsheets better for me and clients (I am not in IT). I use vibe coding DAILY to come up with cool functions for my web apps that people pay me to use.

Comment Yet another Register hit piece (Score 4, Interesting) 240

I'd rather use a slower browser that honors the user's choice of extensions--in particular those that block malicious content and privacy-violating advertising trackers--than an ostensibly faster browser that is created by a company whose entire business model is to gather as much tracking data about you in order to sell it to advertisers.

There are alternatives to both Firefox and Chrome. But choosing to use Chrome because Firefox isn't perfect is either the height of idiocy, or being paid to promote Google products.

Comment Re:Bought a Steam Deck instead... (Score 0, Flamebait) 48

Only an idiot buys a gaming platform just for the tech behind it.

You buy a gaming platform for the platform exclusives. The tech backing it is a legit but secondary factor when considering multi platform games.

There is nothing wrong with the steam deck as a platform. However, it does not offer anything that you cannot find elsewhere. And that is why there is not any significant hype behind it.

END COMMUNICATION

Comment Re: Would anyone have noticed? (Score 0) 61

I own a tiny indie studio in Chicagoland and my peers own the some of the huge studios in Chicagoland.

Cinespace is dead right now. It has ONE show active. The other studios are so dead that they're secretly hosting bar mitzvahs and pickleball tournaments for $1500 a day just to pay property taxes.

My studio is surprisingly busy but I'm cheap and cater to non-union folks with otherwise full time jobs.

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