I'm impressed with people who see the absurd level of technological advancement humanity pulled off in mere 400 years of the scientific method, and think "gee, we'll never surpass nature's trial and error process!!!"
Come on. Unless you think in Biblical time scales, what we did so far was many, MANY orders of magnitude faster than nature managed to do in any equivalent time frame. Human engineering is astoundingly fast. We fly over nature's rate of problem solving. 400 years and we're on the brink of creating artificial brains. Whether it takes us 40 years or 400 more, it's still an eye blink compared to the alternative.
And afterwards things will accelerate even more.