Sure, at first, some people may notice that there used to be thrift stores. For a while. Some old geezers will say "I remember back in my day when you could just buy things, and then sell them--for cash!--and it was nobody's business but yours". But eventually, it will just be normal. Thrift stores will just be added to the list of businesses that aren't allowed to exist, and so they don't exist. And since they don't exist, nobody will care about getting the law overturned, because they will perceive no demand.
After all, who can say how many stores are currently NOT in existence due to over-regulation? Can you even begin to say what businesses are ALREADY not in existence, due to laws? How many picobreweries, tobacconists, brothels, non-health-department-licensed restaurants, non-licensed physicians and dentists? How many cheap delivery services are NOT in existence due to the Post Office monopoly on first class mail? How many people WOULD be growing MJ in their backyard if it was legal? Exactly how many cab drivers WOULD there be in Dallas if they weren't effectively regulated out of existence so as not to compete with light rail projects?
It's easy to say "this law is harmful because if we pass it, a valuable sector of the economy will disappear and thousands of jobs will be lost". It's harder to convince people to see the jobs and the economic sectors that aren't even there, that were never started, or that used to be there.
Out of sight, out of mind. People don't miss what they don't have, and once the regulated sectors of the economy dry up, people don't even see the regulations as unreasonable anymore. If all the thrift stores disappear, it will just be another of a thousand cuts to our economy, and then people will sit back decades later and wonder why the economy sucks and blame the other party for it.