Methotrexate has been around since the 1950's and was one of the first generally safe chemotherapy medications.

It works and isn't hindered by intellectual property laws. Methotrexate is something you want to regulate the safety of. Methotrexate is one drug you really want to contain exactly the dose printed on the label. The methotrexate shortage is pretty much all on manufacturers.

Adderall though is probably a mix between Shire and the DEA. Shire wants people on Vyvanse because they make more per pill on it while the DEA likes that Vyvanse can't be abused (or used) IV. Are they colluding, probably not. Is there an incentive for either to try to fix the problem, not really. Patient and insurers who need to care about what this does to healthcare costs really don't have the clout to break this.

Exactly, methotrexate is not a controlled substance like the amphetamine salts prescribed for ADHD. Methotrexate is an anti-folate used for serious illnesses. Methotrexate has a pretty intense side effect profile, and the last thing any manufacturer would want is liability for injuries caused by a tainted or defective version of a drug that already has a narrow therapeutic window.

This methotrexate shortage in the news getting the most attention is for the intrathecal preparation for administration directly into the cerebro-spinal fluid on the brain side of the blood brain barrier. Intrethecal drugs normally have to be preservative free and any chemicals in it have to be controlled for because the blood brain barrier keeps a lot of chemicals and pathogens on the blood side. If something dangerous gets in it may not be getting back out. Preparing a drug for market like this isn't something that can be half-assed unless you think Russian Roulette is too safe.

Bachmann and Santorum were probably resigned to that when they entered, but Perry entered with the expectation of winning. Perry actually started the flavor of the month trend by knocking off Bachmann. For Perry the culture war isn't his message so much as the thing he was pushed into resorting to as his last agonal breaths before quitting after the South Carolina primary in a dignified manner. Entering the campaign Perry's message was simply "Texas, Fuck Yeah". Seeing 2000 and 2004 along with Texas's attempts to brand itself as America Plus, it wasn't and unrealistic expectation or strategy. It was just a dumb one.

The iPhone release, the App Store introduction, the iPad release... This is nothing.

No.

The public-private partnership has transcended from trend to religion. Obama/Gingrich/Romney-Care illustrates that. If only Hilary-Care happened.

There isn't a chance for Rove or 4chan to decide the president in 2012. Rove isn't endorsing primary candidates so much as eliminating them and there are too many olds for 4chan to take it to the convention.

If I recall correctly a brokered convention wasn't necessary for Obama to trump Hilary as the Democrats used proportional representation in 2008.

In a brokered convention the most Ron Paul would be able to do is pledge his committed delegates to another candidate, provided the pledged delegates agree. Perry will probably be in a similar situation. What those delegates would probably do is support the not-Paul and not-Romney candidate. Huntsman will probably run on the Americans elect ticket turning the Charm up to 11 while being so economically conservative Paul would look like Kim Jung Il, Gary Johnson will run on the libertarian ticket as the marijuana candidate, the greens will put up a nobody, and Obama wins on the democratic ticket.

Normally New Hampshire disagrees with Iowa, so they don't get to pick nominees on their own. It's just that they get to pick one of the two candidates that will be viable for the rest of the slugfest.

Iowans aren't the simpletons that they are often portrayed as. Maybe they aren't Masters of the Universe, but they know what the game is and the game is to milk every candidate for as much as they can. The most they have done so far this election cycle as far as picking candidates is bleed the Bachmann campaign dry, which I wouldn't class as a negative outcome. Mittens isn't my candidate, but he knows that Iowa knows they game and only started making a real effort once the other candidates beat each other to hell.

It's a shitty analogy then. The beauty of DNA is instructs the creation of proteins exactly. In nature advancement happens when mistakes get made trying to copy DNA. Sometimes it results in some sort of advantage like resistance to a disease, while other times it is cancer.

You are right that there is something going on in culture that is problematic. Namely most smartphones and tablets on the market are small iterations of the same hardware with some differences in the polish. The problem isn't why are these interfaces starting to share some details. The problem is that there may be three firms actually manufacturing smartphone hardware and the firms marketing the hardware are fighting to create distinctions in the icing rather than the core product. Even Apple is guilty of this mentality to a degree with so much of its hardware being made by the firm that assembles Xboxs (that and iCloud being hosted on MS Azure).

The most prominent recent example is the Amazon Fire and BlackBerry PlayBook being essentially the same hardware with differing operating systems and storage capacities.

My concern with the removable storage encryption is the lack of a time enforced lockout after x number of failed attempts. I'm one of those dumbasses who held signs this fall in the Occupy protests. I don't mind people seeing my music collection, but I like keeping my communications and calendar a bit more private. Otherwise I'm at the mercy of whatever graphics card for fifty dollars next year someone picks up (even if it is my brother). The phone password is the same as the one used to seed the media card encryption. It still beats the alternatives.

I have the OS 7 curve now and after playing with a blackberry tablet it is on my wishlist, once February passes and unleashes native BES support... On a smartphone the keyboard is irreplaceable if you want to ssh anywhere to do some maintenance on the road. It also makes twitter a hell of a lot easier to use after drinking. Blackberry has always and still has the ergonomic advantage. The iPhone has the advantage when it comes to how many given strangers can figure it out without directions. So long as the iPhone stays of T-Mobile I'll stay off the iPhone because I love my third world priced mobile plan. Android really depends on exactly what phone you pick. I returned the Motorola Charm after 18 hours as I struggled to avoid early osteoarthritis typing on it and it refused to comfortably sit in a pocket. The Optimus T lasted about a year until the whole Google knowing everything I do part got too creepy.

Still I have high hopes for Blackberry 10 seeing the Playbook. If it fails to deliver though I might try to see if I can last the next decade on system 7 phones from eBay. Eventually I may be able to afford the 9900.

What part of consumer electronics involves storing design information as DNA, RNA, or really any nucleic acid.

Somethings Apple may be fighting in court may be "theirs" but the problem is that they seem to be fighting everything. The Android style notification bar seems to have found its way to iOS. There are things that may be worth fighting for and things that may be too stupid to defend.

There is a problem in the federal judiciary in the United States aging as there has been a confirmation crisis running for nearly a decade as our current president and his predecessor have faced increasing opposition to their picks to the federal bench. Not all of this crisis is a legalistic crisis though.

The sad thing for the Android ecosystem is that manufacturer insistence on dumb shit like HTC Sense, MotoBlur, and all of the other custom skins are both aggressors in the look and feel area while mostly being despised by consumers who care. There are plenty of examples of prior art for rounded corners on rectangles littering the countryside on American roads. Beyond that things get murkier.

Different problems require different solutions. The three you propose have been tested in either the courtroom or marketplace checking them against antitrust concerns. If Windows 8 can't work some tablet magic though, Apple is going to be in the same position for that market as late 90's Microsoft.

Last year in my classrooms the most common computing device were netbooks (except on exam days when the TI-30 series came out). This year about a third of the students are sporting iPads, with the rest bringing computers to class opting for full size 14"+ laptops. I can't vouch for other sectors, but what I see on campus is Apple owning the ultraportable war.

The danger for Apple isn't the app store. It is the physical accessories. Cases, stands, and styli are what iPad has and everyone is limited with. It is also what pushes students towards the iPad. Then there's the app problem that comes from the majority tablet having a unique development environment and the rest being more fractured with the Android Java environment, the Playbook's Adobe Air, and whatever one of the windows options wins on the tablet when 8 comes out. An antitrust case against Apple would hit either their restricted development environment for apps they approve, their insistence on considering their form factor unique, or both.

It's why I'm sticking with the older Blackberry. There may not be as many apps. It may be closed source. So long as I don't try to encrypt removable storage it is plenty secure though.

You also can't get much more stable than tiny iterations of the same thing leading to something fairly intuitive and stable. Both iOS and Android may be a full generation or two ahead in terms of user interface, but Apple's too much of an asshat and Android updates are non-existent on most handsets.

There is no reason why an Android 2.2 phone shouldn't be able to do something as simple as apt-get Ice Cream Sandwich.

Conficker did seem like the coming apocalypse until its due date came and went. Then...

Nvir was probably more disruptive.

Nope, nothing to see here. No big industrial equipment runs Mac OS so ruling out those systems means nothing in <i>this</i> case.