Comment Re:Missing? (Score 1) 53
They knew that a broken BRCA2 increased the risk of cancer. The missing link was that high glucose leads to high MGO which inactivates BRCA2.
They started with cells where one copy of the gene is bad in order to more easily see any effect. It is quite possible that given a bad enough type II diabetes, the same effect can happen even with 2 good copies of the gene.