What's out there for poor vision?

hackwrench writes: I like to read on my computer, but when I resize text to be comfortably big, web pages and browsers handle it badly, and some applications don't offer an option to enlarge. Some applications even are bigger than the screen, which Windows doesn't handle well. Lastly, applications consist of bright backgrounds which feels like staring into a headlight. Windows' built in options like magnifier are awkward. What tools are there for Windows to increase text size, make things fit inside the screen, and substitute colors that windows use?