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features
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Description

ESMC represents the newest advancement in the ESM series of protein language models, pushing the boundaries of representation learning within the field of protein biology. With training on billions of evolutionary sequences, it adeptly captures representations that encapsulate a mechanistic understanding of protein structure and function. The model utilizes a transformer architecture, focusing on sequences as its primary modality, and is trained on a vast dataset comprising up to 6 billion proteins. ESMC is tailored for various protein science applications, such as predicting structures, annotating functions, designing proteins, and exploring evolutionary connections among proteins. Additionally, it possesses the capability to create novel proteins based on partial sequences, structures, or functional constraints, thereby enabling researchers to investigate innovative avenues in protein design and biological discovery. Accessible through the Biohub Platform, ESMC can be utilized via an API and the ESM Python package, which includes quickstart resources for installation, API key generation, and platform connectivity, ensuring a seamless experience for users. This comprehensive accessibility encourages a broader engagement with protein research and enhances collaborative efforts in the scientific community.

Description

LigPlot+ serves as the advanced iteration of the original LIGPLOT software, designed for the automatic creation of 2D diagrams depicting ligand-protein interactions. This tool features a user-friendly Java interface that enables users to edit plots effortlessly through simple mouse click-and-drag actions. Besides the improved interface, LigPlot+ introduces several significant upgrades compared to its predecessor. When analyzing two or more ligand-protein complexes that share notable similarities, the software can automatically present their interaction diagrams either overlayed or side by side, with conserved interactions prominently highlighted for easy identification. Additionally, the LigPlot+ suite integrates an enhanced version of the original DIMPLOT program, which is focused on visualizing protein-protein or domain-domain interactions. Users have the flexibility to choose the specific interface they are interested in, allowing DIMPLOT to produce a detailed diagram that illustrates the residue-residue interactions within that interface. For further clarity in interpretation, the residues from one interface can also be displayed in their sequential order, enhancing the overall usability and functionality of the program. This comprehensive approach makes LigPlot+ a valuable tool for researchers seeking to understand complex molecular interactions more intuitively.

API Access

Has API Yes 

API Access

Has API No 

Screenshots View All

Screenshots View All

Integrations

Biohub Yes 
Python Yes 

Integrations

Biohub No 
Python No 

Pricing Details

Free
Free Trial No 
Free Version Yes 

Pricing Details

No price information available.
Free Trial No 
Free Version No 

Deployment

Web-Based Yes 
On-Premises No 
iPhone App No 
iPad App No 
Android App No 
Windows No 
Mac No 
Linux No 
Chromebook No 

Deployment

Web-Based No 
On-Premises No 
iPhone App No 
iPad App No 
Android App No 
Windows Yes 
Mac Yes 
Linux Yes 
Chromebook No 

Customer Support

Business Hours No 
Live Rep (24/7) No 
Online Support Yes 

Customer Support

Business Hours Yes 
Live Rep (24/7) No 
Online Support Yes 

Types of Training

Training Docs Yes 
Webinars No 
Live Training (Online) No 
In Person No 

Types of Training

Training Docs Yes 
Webinars Yes 
Live Training (Online) No 
In Person Yes 

Vendor Details

Company Name

Biohub

Founded

2016

Country

United States

Website

biohub.ai/models/esmc

Vendor Details

Company Name

EMBL-EBI

Country

United Kingdom

Website

www.ebi.ac.uk/thornton-srv/software/LigPlus/

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