A Phase 1 trail of a universal mRNA-based influenza vaccine is under way at Duke Unversity in Durham, North Carolina. It's being developed by the National Institute of Allergy and Infectious Diseases' (NAID) Vaccine Research Center (VRC). New Atlas reports: Some 50 participants aged 18-49 will be split into three groups and given 10, 25 and 50 micrograms of the active drug, respectively. When optimal dosage is then determined, another 10 participants will get this measured jab. There will also be an additional group who will receive a current quadrivalent seasonal flu shot, so researchers have a comparative dataset that takes into account the immune response and safety of readily available influenza vaccines. Those in the trial will then be regularly evaluated over 12 months to see how the drug's immune response has fared and to assess its short-term and long-term safety.

This trial comes after the initial NIAID's Vaccine Research Center study on the safety and immune response of the H1ssF (H1 hemagglutinin stabilized stem ferritin) nanoparticle vaccine. The Phase 1 trial, from April 2019 to March 2020, delivered broad antibody responses in the 52 participants aged 18-70. The results of the trial were published last month in the journal Science Translational Medicine.

The H1ssF vaccine targets the flu protein hemagglutinin. One section of this protein -- the 'head' -- changes as the virus evolves into different strains, but the stem of the protein is much slower to be altered and remains fairly constant throughout influenza mutations. The researchers believe herein lies the key to a long-lasting, effective universal preventative vaccine. The new trial combines the H1ssF nanoparticle vaccine with messenger RNA (mRNA) as the platform, with the end goal that it'll deliver a more efficient, targeted immune response.

An anonymous reader quotes a report from Ars Technica: On Monday, the journal Nature released a report from Nanjing University researchers that had attempted to replicate an earlier paper that described a compound that superconducted at room temperature and relatively moderate pressures. Despite persuasive evidence that they've produced the same chemical, the team indicates they see no sign of superconductivity, even down to extremely low temperatures. The failure will undoubtedly raise further questions about the original research, which came from a lab that had an earlier paper on superconductivity retracted.

In 2020, the lab run by Ranga Dias at the University of Rochester reported a carbon-hydrogen-sulfur compound formed at extreme pressures could superconduct at room temperature. But the results were controversial, partly because it wasn't clear that the paper included enough information for anyone else to produce the same conditions and because Dias was uncooperative when asked to share experiment data. Eventually, it became apparent that the team had used undocumented methods of obtaining some of the data underlying the paper, and it was retracted. But Dias continued to claim that the superconductivity was present. (There's a good overview of the controversy on the American Physical Society website.)

Despite Nature retracting one of Dias' papers, the journal published another paper on superconductivity from his group. In this case, a lutetium-hydrogen chemical doped with nitrogen was reported to superconduct at room temperature but at much lower pressures, which could allow it to be tested with somewhat less specialized equipment. Given the history, the claim was greeted with an even higher degree of skepticism than the earlier paper.

Zoom will be integrating Anthropic's AI Assistant across its productivity platform, starting with its Contact Center product to help businesses with customer support inquiries. The Verge reports: Zoom says Claude, a chatbot Anthropic launched in March, should help customer support agents by creating "better self-service features" that can help guide customers toward relevant solutions. It will also soon be able to surface necessary resources for agents while they're serving customers. The company is vague about how it will implement Claude in other areas of the app -- like Team Chat, Meetings, Phone, Whiteboard, and Zoom IQ -- but Zoom will likely leverage the assistant to help it compete with other productivity apps that use AI, like Slack. Zoom already has a suite of AI-powered capabilities available through Zoom IQ, an assistant it built through a partnership with OpenAI. So far, Zoom IQ can generate summaries and message drafts as well as create whiteboards based on text prompts.

Additionally, Zoom Ventures, a Zoom offshoot that invests in startups, also announced that it has made an investment in the Google-backed Anthropic. Zoom says working with both Anthropic and OpenAI helps bolster its "federated approach" to AI.

According to S&P Global Mobility, the average age of light vehicles on the road in the U.S. is now at an all-time high of 12.5 years, up three months from 2022. Two decades ago, their average was 9.7 years. Axios reports: The impact: The transition from gas to electric cars will take decades.

It'll likely take until at least 2050 -- and possibly longer -- before most gas-powered cars are off the road, Campau says.

Of note: EV longevity is going in the opposite direction. Their average age fell from 3.7 years in 2022 to 3.6 years in 2023, in part due to an upswing in new purchases.

By the numbers: About 6.6% of battery-powered EVs bought between 2013-2022 have left the passenger fleet, compared with 5.2% of non-EVs -- but [...] it's too early to know why. EVs generally come with an 8-year, 100,000-mile warranty -- but early evidence suggests they last longer than that, according to an analysis by Recurrent, which tracks battery data. Carmakers say electric cars should last 15 to 20 years, but modern EVs haven't been around long enough to validate that claim. The report projects that there will be fewer than 100 million passenger cars on the road within the next 18-24 months -- a low not seen since 1978. By 2028, at least 7 in 10 vehicles on the road will be pickups, SUVs or crossovers.

An anonymous reader quotes a report from KrebsOnSecurity: Countless smartphones seized in arrests and searches by police forces across the United States are being auctioned online without first having the data on them erased, a practice that can lead to crime victims being re-victimized, a new study found (PDF). In response, the largest online marketplace for items seized in U.S. law enforcement investigations says it now ensures that all phones sold through its platform will be data-wiped prior to auction.

Researchers at the University of Maryland last year purchased 228 smartphones sold "as-is" from PropertyRoom.com, which bills itself as the largest auction house for police departments in the United States. Of phones they won at auction (at an average of $18 per phone), the researchers found 49 had no PIN or passcode; they were able to guess an additional 11 of the PINs by using the top-40 most popular PIN or swipe patterns. Phones may end up in police custody for any number of reasons -- such as its owner was involved in identity theft -- and in these cases the phone itself was used as a tool to commit the crime. "We initially expected that police would never auction these phones, as they would enable the buyer to recommit the same crimes as the previous owner," the researchers explained in a paper released this month. "Unfortunately, that expectation has proven false in practice."

Beyond what you would expect from unwiped second hand phones -- every text message, picture, email, browser history, location history, etc. -- the 61 phones they were able to access also contained significant amounts of data pertaining to crime -- including victims' data -- the researchers found. [...] Also, the researchers found that many of the phones clearly had personal information on them regarding previous or intended targets of crime: A dozen of the phones had photographs of government-issued IDs. Three of those were on phones that apparently belonged to sex workers; their phones contained communications with clients. "We informed [PropertyRoom] of our research in October 2022, and they responded that they would review our findings internally," said Dave Levin, an assistant professor of computer science at University of Maryland. "They stopped selling them for a while, but then it slowly came back, and then we made sure we won every auction. And all of the ones we got from that were indeed wiped, except there were four devices that had external SD [storage] cards in them that weren't wiped."

According to Agence France-Presse, France has opened an investigation into planned obsolescence of Apple products. From the report: The probe into purported misleading commercial practices and planned obsolescence has been under way since December, the Paris prosecutor's office said. It follows a complaint filed by the Halt Planned Obsolescence (HOP) association.

HOP said it hoped the investigation would demonstrate the iPhone maker was "associating the serial numbers of spare parts to those of a smartphone, including via microchips, giving the manufacturer the possibility of restricting repairs by non-approved repairers or to remotely degrade a smartphone repaired with generic parts." The association called on Apple "to guarantee the right to repair devices under the logic of real circular economy."

OpenAI CEO Sam Altman appeared before a Senate Judiciary subcommittee, along with IBM chief privacy officer Christian Montgomery and NYU professor Gary Marcus, to testify about the dangers posed by generative artificial intelligence. Altman said he'd welcome legislation in the space and urged Congress to work with OpenAI and other companies in the field to figure out rules and guardrails. Axios reports: Altman argued that generative AI is different and requires a separate policy response. He called it a "tool" for users that cannot do full jobs on its own, merely tasks. Altman called for a government agency that would promulgate rules around licensing for certain tiers of AI systems "above a crucial threshold of capabilities." He said: "My worst fear is we cause significant harm to the world."

Sen. Dick Durbin (D-Ill.) called it "historic" that a company was coming to Congress pleading for regulation. IBM's Montgomery said it was important to regulate risks, not tech itself. "This cannot be the era of move fast and break things," she said.

An anonymous reader quotes a report from Ars Technica: StorCentric, the holding company for the Drobo and Retrospect brands, filed for Chapter 11 bankruptcy in late June 2022. Now, AppleInsider reports that, based on an email sent by StorCentric, the bankruptcy shifted from reorganization-minded Chapter 11 to liquidation-focused Chapter 7 in late April.

The writing for Drobo was on the wall, or at least on its website. Text at the top of the homepage notes that, as of January 27, 2023, Drobo products and support for them are no longer available. "Drobo support has transitioned to a self-service model," the site reads. "We thank you for being a Drobo customer and entrusting us with your data." Drobo began in 2005 as Data Robotics and launched into the tech consciousness with the original Drobo, a "storage robot." The marquee feature was being able to hot-swap drives of nearly any size without migrating data.

A former Apple software engineer was charged with stealing Apple's autonomous technology for a Chinese self-driving car company, the Department of Justice announced Tuesday. From a report: Weibao Wang worked as a software engineer at Apple from 2016 to 2018, a DOJ indictment said. Wang worked on Apple's Annotation Team and was granted "broad access" to databases which the Justice Department said could only be accessed by 2,700 of Apple's 135,000 employees. Wang is the third former Apple employee to be accused of stealing autonomous trade secrets for China.

Wang has been charged with six separate counts involving the theft or attempted theft of Apple's "entire autonomy source code," tracking systems, behavior planning for autonomous systems, and descriptions of the hardware that was behind the systems. A year into his employment, four months before he quit his job at Apple, Wang accepted a job at the U.S.-based subsidiary of an unnamed Chinese company that was developing autonomous driving technology and he began to siphon "large amounts" of sensitive commercial technology and source code, the indictment alleges.

South Korea's LG Display will start supplying high-end TV panels to Samsung Electronic from as early as this quarter, three sources told Reuters, in a deal that would help the loss-making flat-screen maker turn profitable. From the report:LG Display aims to supply 2 million units next year and boost shipments to 3 million and 5 million units in subsequent years, two sources with direct knowledge of the matter said. Initial supplies to Samsung would likely be 77-inch and 83-inch white OLED (WOLED) TV panels. For Samsung, the deal highlights how it is looking to expand in high-end organic light emitting diode (OLED) TVs as competition heats up in the lower end with Chinese vendors. OLED panels cost nearly five times more than liquid-crystal display (LCD) panels. With this deal, Samsung could overtake Sony as the second largest supplier of OLED TVs globally.

A Russian man was charged by US authorities in connection with his alleged role with multiple ransomware gangs that attacked hospitals, schools and police departments. From a report: Mikhail Pavlovich Matveev, who was known online as Wazawaka, was an active member of three ransomware gangs that collectively demanded $400 million from victims and received nearly $200 million in ransom payments, according to the Department of Justice. Ransomware groups typically hack into computer networks and deploy malicious software that encrypts computers and makes them unusable. The groups demand extortion payments in cryptocurrency and threaten to leak stolen data online if the ransom is not paid.

Matveev was allegedly a member of the Lockbit, Babuk and Hive ransomware gangs. Those groups are "ranked among the most active and destructive cybercriminal threats in the world," Philip Sellinger, the US attorney for the district of New Jersey, wrote in an indictment. Matveev, along with other members of the ransomware gangs, attacked as many as 2,800 victims in the US and around the world, Sellinger wrote. The alleged victims include the Metropolitan Police Department in the District of Columbia, which was attacked with ransomware in 2021. The hackers proceeded to publish dozens of stolen personnel files. The groups also targeted churches and nonprofits, the Department of Justice said.

Environmental DNA research has aided conservation, but scientists say its ability to glean information about human populations and individuals poses dangers. From a report: David Duffy, a wildlife geneticist at the University of Florida, just wanted a better way to track disease in sea turtles. Then he started finding human DNA everywhere he looked. Over the last decade, wildlife researchers have refined techniques for recovering environmental DNA, or eDNA -- trace amounts of genetic material that all living things leave behind. A powerful and inexpensive tool for ecologists, eDNA is all over -- floating in the air, or lingering in water, snow, honey and even your cup of tea. Researchers have used the method to detect invasive species before they take over, to track vulnerable or secretive wildlife populations and even to rediscover species thought to be extinct. The eDNA technology is also used in wastewater surveillance systems to monitor Covid and other pathogens. But all along, scientists using eDNA were quietly recovering gobs and gobs of human DNA. To them, it's pollution, a sort of human genomic bycatch muddying their data. But what if someone set out to collect human eDNA on purpose?

New DNA collecting techniques are "like catnip" for law enforcement officials, says Erin Murphy, a law professor at the New York University School of Law who specializes in the use of new technologies in the criminal legal system. The police have been quick to embrace unproven tools, like using DNA to create probability-based sketches of a suspect. That could pose dilemmas for the preservation of privacy and civil liberties, especially as technological advancement allows more information to be gathered from ever smaller eDNA samples. Dr. Duffy and his colleagues used a readily available and affordable technology to see how much information they could glean from human DNA gathered from the environment in a variety of circumstances, such as from outdoor waterways and the air inside a building. The results of their research, published Monday in the journal Nature Ecology & Evolution, demonstrate that scientists can recover medical and ancestry information from minute fragments of human DNA lingering in the environment. Forensic ethicists and legal scholars say the Florida team's findings increase the urgency for comprehensive genetic privacy regulations.

Twenty years ago, pinball seemed to be circling the drain. In the 1980s and 1990s video games stole market share from the mechanical sort, and home games-consoles stole market share from arcades. By 2000 WMS, the Chicago-based maker of the Bally and Williams brands of pinball machines, then the biggest manufacturer, closed its loss-making pinball division to focus on selling slot machines. Yet today, pinball is thriving again, both at places like Logan Arcade and in people's homes. Economist: Sales of new machines have risen by 15-20% every year since 2008, says Zach Sharpe, of Stern Pinball, which after WMS closed became the last remaining major maker. "We have not looked back," he says. Next year the firm is moving to a new factory, twice the size of its current one, in the north-west suburbs of Chicago. Sales of used machines are more buoyant still -- some favourites, such as Stern's Game of Thrones-themed game, can fetch prices well into five figures. Josh Sharpe, Zach's brother and president of the International Flipper Pinball Association, says that last year the IFPA approved 8,300 "official" tournaments, a four-fold increase on 2014.

What is driving the boom? Much of it is nostalgia. A generation raised on pinball in arcades in the 1980s and 1990s are now at an age where they have disposable income, and kids with whom they want to play the games they played as children. Marty Friedman, who runs an arcade in Manchester, a tourist town in southern Vermont, says that he and his wife opened their business after he realised it would allow him to indulge his hobby. "I compiled a list of the games I felt were essential to a collection you would deem museum-worthy," he said, and went about acquiring them. But canny marketing is also drawing in fresh blood. Newer Stern machines are now connected to the internet, so players can log in and have their scores uploaded to an online profile. Both Sharpes suggest that the mechanical nature of the games appeals to people bored with purely screen-based play.

Marines and sailors who were exposed to toxic water at Camp Lejeune, N.C., are much more likely to suffer from Parkinson's disease than their counterparts who were stationed elsewhere, according to a study published Monday. From a report: Troops stationed at Camp Lejeune for even just a few months during the years 1975-85 are 70% more likely to suffer from Parkinson's disease than troops who were at Camp Pendleton, Calif., according to findings from researchers who accounted for other factors in making their determination. Their report was published by the Journal of the American Medical Association. The Department of Veterans Affairs-funded study was led by Dr. Samuel Goldman, a professor of medicine at the University of California, San Francisco Medical School and a staff physician at the San Francisco VA Medical Center.

The Departments of Defense and Veterans Affairs have acknowledged for years that troops based at Camp Lejeune and other North Carolina facilities from the early 1950s until the mid-1980s were exposed to a number of harmful chemicals in the drinking water, including the solvents benzene and trichloroethylene, which are linked to Parkinson's. Water processed for the base was contaminated by improper chemical-disposal procedures from an off-base dry cleaner, leaky underground storage tanks, industrial spills and other problems for decades, according to the Centers for Disease Control and Prevention. A million veterans and family members have been potentially affected, according to the federal Agency for Toxic Substances and Disease Registry.