Alternatives to LigPlot+

AutoDock is a set of automated docking tools. It predicts how small molecules, such sub- or drug candidates, will bind to a receptor with a known 3D structure. It has been improved over the years to add new functionalities and multiple engines were developed. AutoDock 4 is the current version, and AutoDock Vina is the latest. AutoDock-GPU is an accelerated version that runs hundreds of times faster than the original single CPU docking code. AutoDock 4 is actually composed of two main programs. Autodock docks the ligand to a list of grids that describe the target protein. Autogrid pre-calculates the grids. The atomic affinity grids can also be visualized. This can be used to help organic synthetic chemists create better binders.

SYNTHIA™ Retrosynthesis software, developed by computer scientists and coded by chemists, allows scientists to quickly and easily navigate novel and innovative pathways for novel and previously published target molecules. You can quickly and efficiently scan hundreds pathways to identify the best options for your needs. Discover the most cost-effective route to your target molecule with the latest visualization and filtering features. You can easily customize the search parameters to eliminate or highlight reactions, reagents, or classes of molecules. Explore innovative and unique syntheses to build your desired molecule. Easy to generate a list for starting materials that are commercially available for your synthesis. ISO/IEC 27001 Information Security Certification will guarantee the confidentiality, integrity and protection of your data.

Discngine is a France company that was founded in 2004, and produces a software product named 3decision. 3decision includes training through documentation, live online, webinars, in person sessions, and videos. 3decision has a free trial. 3decision is a type of drug discovery software. 3decision includes phone support support and online support. Regarding deployment requirements, 3decision is offered as SaaS software.

Site-Identification by Ligand Competitive Saturation generates 3D maps (FragMaps), showing interaction patterns for chemical functional group with your target molecule. Site-Identification through Ligand Competitive Saturation generates 3D maps, (FragMaps), of interaction patterns for chemical functions groups with your target molecule. SILCS reveals the intricacies and provides tools to optimize ligand scaffolds through qualitative and quantitative binding pocket insights. This allows for faster and more effective drug design. SILCS employs multiple small molecule probes that have different functional groups and explicit solvent modeling to perform protein target mapping. Visualize positive interactions with the target macromolecule. Get insights to design better binding agents with the best functional groups.

Aurora uses quantum mechanics, thermodynamics and an advanced continuous-water model for solvation effects in order to calculate ligand binding affinities. This approach is significantly different from the binding affinity predictions that are often based on scoring functions. Aurora algorithms are able to produce more precise and reliable binding free energies values by including the entropy as well as the aqueous electrostatic contribution directly into the calculations. The binding free energy is the measure of interaction between a ligand and a protein. The free energy (F), which is a thermodynamic quantity directly related to the experimentally measurable value for inhibition constant (IC50), and depends on the statistical properties of interacting molecules as well as electrostatic, quantum, and aqueous solver forces, is a thermodynamic quantity. Two major contributors to F's non-additivity are 1) the electrostatic and the solvation energy, and 2) the entropy.

VeraChem LLC was established in 2000 to advance computer-aided drug discovery. These methods are implemented in high-performance software and provide comprehensive support to users. This is a key strategy of VeraChem LLC for product development. Current VeraChem software capabilities include host-guest and protein-ligand binding affinity prediction, fast calculation and computation of partial atomic charges for druglike compounds, computation and force of energies and forces using all the most commonly used empirical force field, automatic generation and generation of alternate resonance forms for drug-like substances, conformational search using the powerful Tork algorithm and automatic detection and removal of topological and 3D-molecular symmetries. VeraChem's software packages were built from a modular code base.

Makya is a user-friendly SaaS-based platform for AI-driven drug design focusing on Multi-Parametric Optimization. It allows the design of novel compounds that are easy to make in accordance with a multiobjective blueprint at unprecedented speeds, performance and diversity. Makya has multiple generative algorithms that cover different use cases, from hit discovery to lead optimizing: fine-tuning to find optimal solutions in your chemical space according to your project blueprint; novelty to find new ideas of high novelty for rescaffolding/hit discoveries; forward to design a focused collection of compounds easily accessible using commercial starting materials. The new Makya 3D Module enhances the user-experience and scientific utility of Makya. Makya 3D offers a wide range of 3D modeling capabilities in both ligand and structure-based pipelines. You can now use these 3D scores to guide generation natively within Makya.

BioNeMo, an AI-powered cloud service for drug discovery and framework, is built on NVIDIA NeMo Megatron. It is used to train and deploy large biomolecular Transformer AI models at supercomputing scale. The service provides pre-trained large language models (LLMs), native support for common file types for proteins, DNA, and chemistry, as well as data loaders for SMILES molecular structures and FASTA amino acid and nucleotide sequencings. You can also download the BioNeMo framework to run on your own infrastructure. ESM-1, which is based on Meta AI’s state-of the-art ESM-1b and ProtT5 respectively, are transformer-based protein-language models that can be used for learning embeddings for tasks such as property prediction and protein structure. BioNeMo will offer OpenFold, a deep-learning model for 3D structure prediction and novel protein sequences.

Kanteron Platform ingested digital pathology slides, medical images, and patient data from modalities and sequencers. It then provided a complete data toolkit for all hospital network teams. Precision Medicine at the point-of-care: Pharmacogenomics is used to prevent adverse medication events. It also incorporates data sources that have drug-gene interactions that were not previously available in easily accessible formats (e.g. Tables in a PDF document) and implementing the major Pharmacogenomic Databases (like PharmGKB or DGIdb, OpenTargets ...). This allows the user to refine their query to specific gene families, types, interactions, etc. Flexible AI allows you to choose the data set that is most appropriate for your use case and then apply it to your relevant medical images.

metaphactory converts your data into actionable, contextual and consumable knowledge. It also drives continuous decision intelligence. Intuitive interfaces that are intuitive and out-of-the box for searching, browsing, and exploring your Knowledge Graph. It is possible to create custom interfaces using low-code that allow business users to interact with the Knowledge Graph. Start small, iterate often, and add new use cases, data, and users as you go. Low-code platform for building applications and agile knowledge management.

Clara's domain specific tools, AI pretrained models, accelerated applications, and accelerated AI applications are enabling AI advances in many fields, including medical device, imaging, drug discovery and genomics. Holoscan allows you to explore the entire pipeline of medical device deployment and development. With the NVIDIA IGX Developer Kits, you can build containerized AI apps using the Holoscan SDK. The NVIDIA IGX SDK includes pre-trained AI model, healthcare-specific acceleration libraries and reference applications for medical devices.

These intricate, complex machines are proteins. They are the building blocks of all biological processes, not only in your body, but in every living being. They are the building blocks of all life. There are currently around 100 million distinct proteins. Many more are discovered every year. Each protein has a unique 3D shape, which determines how it functions and what it does. It is expensive and time-consuming to determine the exact structure of each protein. This means that we only have a small number of proteins in our database. This gap is rapidly growing and we need to be able to predict the structure of millions unknown proteins. This could help us not only tackle disease but also help us find new medicines more quickly. It may also help us unlock the mysteries of life.

Genedata Biologics®, streamlines the discovery of biotherapeutics. This includes bispecifics and ADCs as well as TCRs, CARs-Ts, CARs-Ts, CARs, and AAVs. It integrates all discovery workflows, making it the most popular platform in the industry. This allows you to focus on innovation and is the most widely used. A first-in-class platform that digitalizes biotherapeutic discovery accelerates research. The platform simplifies complex R&D processes by allowing for the creation, tracking, testing, and evaluation of novel biotherapeutics drugs. It can work with any format: antibodies, bi- and multi-specifics as well as ADCs, novel scaffolds, therapeutic proteins, and engineered therapeutic cell line such CAR-T cells and TCRs. Genedata Biologics acts as a central data backbone that integrates all R&D processes. This includes library design, immunizations, selections, panning, molecular Biology, screening, protein engineering and expression, as well as candidate development and manufacturability assessment.

Rare diseases are often poorly understood and only a small amount of information is available to support drug discovery programs. Healnet, an AI platform that analyzes millions of data points related to drug and disease, helps overcome these challenges. It identifies novel connections that could lead to new treatment options. We can simultaneously run multiple stages at scale by applying frontier technologies throughout the discovery and development process. It's a simple model that can be used by almost all pharmaceutical companies. One disease, one target and one drug. The next generation in drug discovery is AI-powered and parallel. The key three paradigms of drug discovery are combined.

Dotmatics is the global leader in R&D scientific software that connects science, data, and decision-making. More than 2 million scientists and 10,000 customers trust Dotmatics to accelerate research and help make the world a healthier, cleaner, and safer place to live.

HyperProtein, Hypercube, Inc.'s latest product, focuses on the computational science of protein sequences. The product allows you to analyze one-dimensional sequences of protein as well as subsequent three-dimensional structures. The product's most important feature is the relationship between structure and sequence. HyperProtein is not like other software programs that can perform specific functions, such as sequence alignment or protein sequence sequence, but it does combine a variety of Bioinformatics tools and Molecular Modeling tools that are related to the science that begins with a protein sequence.

The biopharmaceutical market is complex today. There are growing demands for better specificity and safety, new treatment classes, and more complex mechanisms of disease. To keep up with this complexity, we need to have a better understanding of therapeutic behavior. Simulation and modeling provide unique opportunities to explore biological and physical processes down to the atomic levels. This can be used to guide physical experimentation and accelerate the discovery and development process. BIOVIA Discovery Studio brings together more than 30 years of peer reviewed research and world-class in-silico techniques like molecular mechanics and free energy calculations. It also allows for biotherapeutics developmentability and other related topics into one environment. It gives researchers a complete toolkit to explore the nuances in protein chemistry and to catalyze the discovery of small and big molecule therapeutics, from Target ID to Lead Optimizement.

Eidogen-Sertanty’s Target Informatics platform (TIP), is the first global structural informatics system. It enables researchers to examine the druggable genome from an structural perspective. TIP increases the rapidly expanding body experimental protein structure information and transforms structure based drug discovery from an inefficient, data-scarce discipline to a high-throughput science with rich data. TIP is a tool that bridges the knowledge gap between bioinformatics (bioinformatics) and cheminformatics. It provides drug discovery researchers with a knowledge bank of information that is both unique and highly complementary to existing bio- and cheminformatics platform information. TIP's seamless integration between structural data management technology and unique target-to-lead analysis capabilities enhances every stage of the discovery pipeline.

AIDDISON™, a drug discovery software, combines the power and efficiency of artificial intelligence (AI), computer-aided design (CADD), and machine learning (ML) to provide a valuable toolkit that can be used for medicinal chemistry. It is a unified platform that integrates all aspects of virtual screening, including ligand-based design and structure-based design. It also supports methods for in silico lead optimization and discovery.

A series of carefully planned experiments can help you discover biological biomarkers, uncover disease mechanisms, find new drugs, or identify protein levels changes. It's easy to unlock the power of MS/Proteomics. This allows you to focus on the biological complexity and get closer to the moment for discovery. Our automated, repeatable workflow makes it easier to start experiments and reduce turnaround times. This gives you the flexibility and control to make decisions and act on them immediately. Our proteomics data processing workflow allows you to concentrate on biological insights and human to human collaboration. It is built to scale repeatedly. We have made repetitive and heavy processing easy to use the cloud, making it a seamless and enjoyable experience. Intelligent Proteomics seamlessly integrates complex moving parts to allow larger experiments to be processed, analyzed, and reported with ease.

Artificial Intelligence and RNA sequencing (RNA–seq data) are both a necessity and a way to develop therapeutics that target splicing mistakes. Machine learning allows us to quickly identify new splicing mistakes and design therapeutic compounds to correct them. SpliceCore, our AI platform for RNA therapeutics research, is what we call SpliceCore. This technology platform was specifically designed for the analysis and interpretation of RNA sequencing data. It can identify, validate and test hypothetical drug targets quicker than traditional methods. Our proprietary database of over 5 million potential RNA-splicing errors is the heart of SpliceCore. It is the world's largest database of splicing mistakes and is used to test all RNA sequencing data that is submitted for analysis. Scalable cloud computing allows us to process large amounts of RNA sequencing data efficiently at a higher speed and lower cost, thereby exponentially accelerating therapeutic innovation.

PyQtGraph is a pure Python graphics and GUI library based on PyQt/PySide or NumPy. It is intended for use in mathematics/scientific/engineering applications. Although written entirely in Python, the library is extremely fast thanks to its heavy use of NumPy to perform number crunching and Qt GraphicsView framework for fast display. PyQtGraph is available under the MIT open source license. Interactive view boxes for basic 2D plotting. Line and scatter plots. Data can be scaled/panned with the mouse. Rapid drawing allows for real-time data display. Displays all data types (int, float, any bit depth, RGB, RGBA or luminance). Multidimensional images can be sliced at arbitrary angles using these functions (great for MRI data). Rapid update for video display and real-time interaction Image display with interactive level control and lookup tables. Mesh rendering with isosurface generator. Interactive viewports can be rotated/zoomed with the mouse. For easier programming, use the basic 3D scenegraph.

Discngine is a software organization located in France that was started in 2004 and provides software named Discngine Assay. Discngine Assay includes training through documentation, live online, webinars, in person sessions, and videos. Discngine Assay is a type of drug discovery software. Discngine Assay is offered as SaaS software. Discngine Assay has a free trial. Discngine Assay provides phone support support and online support. Some alternatives to Discngine Assay are Eidogen-Sertanty Target Informatics Platform (TIP), Nautilus LIMS, and Chemia.

CDD Vault allows you to intuitively organize chemical structures, biological study data, as well as collaborate with external or internal partners via a simple web interface. Start a free trial to see how easy it can be to manage drug discovery data. Tailored for You Affordable Scales with your project team Activity & Registration * Electronic Lab Notebook * Visualization * Inventory * APIs

StarDrop™, a comprehensive suite of integrated software, delivers the best in silico technology within a highly visual interface. StarDrop™, which allows seamless flow between the latest data, predictive modeling, and decision-making regarding the next round or synthesis, improves the speed, efficiency and productivity of the discovery process. A balance of different properties is essential for successful compounds. StarDrop™, which guides you through the multi-parameter optimization challenge, helps you target compounds with the highest chance of success. It also saves you time and resources by allowing you to synthesize fewer compounds and test them less often.

Genedata Imagence®, allows you to train a deep neural net to classify cellular characteristics in HCS images. This will give you objective, high-quality results. It automates your analysis to allow assay biologists to harness the power of deep learning algorithms. Genedata Imagence allows biologists to immediately and directly analyze HCS imaging data with sophisticated deep learning techniques using no specialized algorithmic knowledge. Don't hide your analysis behind abstract lines of code. Genedata Imagence's intuitive interface makes it easy to QC and explore data at every stage.

Cortellis™, a suite of life science intelligence software solutions, reveals hidden insights in data. This allows you to make better informed decisions throughout the R&D process. We have taken out the tedious work of finding, integrating and analysing data so that you can concentrate on the crucial decisions required to bring your products to market quicker. Cortellis provides unique data analysis that is rich in domain knowledge, industry insight, and therapeutic expertise. This allows you to unlock hidden insights that will allow you to make data-driven decisions that drive innovation. With the most comprehensive and deepest intelligence, you can get precise and actionable answers to specific questions throughout the R&D process. Cortellis is an indispensable part your daily work flow.

Polly allows you to harness the power of biomedical information. The Polly Platform allows you to scale batch jobs, workflows and visualization applications. Polly supports resource pooling, optimizes resource allocation based upon your usage requirements, and makes use of spot instances when possible. This results in optimization, efficiency, quicker response time, and lower costs for resources. Access a dashboard that allows you to monitor and track resource usage and costs in real-time. This will allow you to reduce overheads when resource management is done by your IT team. Polly's infrastructure is built around version control. Polly uses a combination dockers and interactive notebooks to ensure version control for your analyses and workflows. We have created a mechanism that allows data, code, and the environment to co-exist. This, along with cloud data storage and the ability for users to share projects, ensures reproducibility in every analysis.

DNAnexus Apollo™, accelerates precision drug discovery through collaboration that draws critical insights from omics data. Precision drug discovery requires the collection and analysis of large volumes of clinical and omics data. These data sets are extremely rich, but many legacy and home-grown informatics tools cannot handle their complexity and size. Silos, insufficient collaboration tools, and complex regulatory and security requirements can all hinder precision medicine programs. DNAnexus Apollo™, which supports precision drug discovery programs, empowers scientists and clinicians to analyze and explore omics and clinical data in a single environment built on a robust and scalable cloud platform. Apollo allows them to share data, tools and analyses securely with peers and colleagues from all over the world, regardless of whether they are on another floor or another continent.

NoviSight 3D Cell Analysis Software advances your discovery by providing statistical information for spheroids, and other 3D objects in microplate based experiments. It allows you to quantify cell activity in three dimensions, capture rare events more easily, increase detection sensitivity, and obtain accurate cell counts. NoviSight software has a simple user interface that allows you to perform analysis, recognition, and statistical analyses. NoviSight software's True 3D technology allows you to easily check the morphology and size of your samples. To speed up your research, measure a variety of cell nuclei parameters such as volume and sphericity. You can also analyze 3D cell models that are physiologically relevant to your work. The software can be used to analyze objects of interest and provide spatiotemporal and morphological information in 3D space. You can detect objects from whole structures to subcellular details and analyze changes in spheroids.

FCS Express™ gets you from raw data to easily-understandable, beautifully formatted, presentation-ready results more easily and in less time than any other flow cytometry software. You've probably had to copy and paste data tables into another software to make your data more understandable and visually appealing. You've probably had to manage your data in multiple software packages, such as Microsoft Excel™, GraphPad Prism™, or Microsoft Excel™. It was difficult to find everything you needed in one program. Learning flow cytometry software shouldn't be a barrier to getting the best results from your data. FCS Express is designed to look and feel like familiar Microsoft Office™, so you can already be an expert before you even start.

Advanced molecular modeling can transform drug discovery and materials research. Our physics-based computational platform combines differentiated solutions for predictive modelling, data analytics, collaboration, and collaboration to allow rapid exploration of chemical space. Our platform is used by industry leaders around the world for drug discovery and materials science in fields such as aerospace, energy, semiconductors and electronics displays. The platform powers our drug discovery efforts, from target identification through hit discovery to lead optimization. It also powers our research collaborations to create novel medicines for critical public healthcare needs. Our team includes more than 150 Ph.D. scientists. This allows us to invest heavily in R&D.

BIOiSIMTM, a revolutionary 'virtual drug engine', is the first-in-class tool that allows drug developers to narrow down the number drugs that have potential value in treating or curing specific diseases or illnesses. We offer a variety of translational-based solutions that can be customized for your clinical and pre-clinical programs. All of these solutions are based on our BIOiSIMTM platform, which is a proven and validated platform for small molecules, large molecule, and viruses. Our models are built using data from thousands upon thousands of compounds across seven species, which gives them a robustness that is rare in the industry. The platform is focused on human outcomes and has at its core a translatability tool that transforms insights across species. The BIOiSIMTM platform is available before preclinical animal trials begin, which allows for earlier insights and saves on expensive outsourced experimentation.

ArgusLab is a program that allows you to molecular model, graphically, and design drugs for Windows operating systems. Although it is becoming a little outdated, it remains very popular. There have been more than 20,000 downloads to date. ArgusLab can be downloaded for free. You don't have to sign anything. If you're teaching a class in which ArgusLab might be useful, you can print as many copies as necessary. You cannot redistribute ArgusLab to other websites or sources. You may link to this website on your own websites, however. ArgusLab is being port to the iPad in a low-key effort. I have also worked with Qt cross-platform development environment to support Mac, Linux, and PC.

Global biopharmaceutical drug patents and generic entry business intelligence. Anticipate future budget needs and proactively find generic sources. Examine past successes of patent challengers to identify research paths for competitors. Inform portfolio management decisions on future drug development. Predict brand drug patent expiration, identify generic supplier, and prevent overstocking of branded drugs. Get formulation and manufacturing information. Identify final formulators, repackagers and relabelled.

To drive precision medicine programs that work, pharmaceutical companies require comprehensive genomic information. However, decisions are often made with only 10% of the data available. Genomenon provides 100% of the data. ProdigyTM Patient Landscapes are a cost-effective and efficient natural history research solution for pharmaceuticals. They enhance insights from retrospective and prospective health data to support the development rare disease therapies. Genomenon uses an AI-driven approach to deliver a thorough and expert assessment of all patients in the medical literature in a fraction time. Get a complete overview of every genomic biomarker in the medical literature. Every scientific assertion is supported with empirical evidence from medical literature. Identify all genetic drivers and determine which variants are pathogenic according ACMG clinical standards.

BC platforms uses the latest science, unique technology capabilities and strategic partnerships to accomplish our mission of revolutionizing drug discovery, personalizing care, and transforming medicine. Modular, flexible platform that integrates healthcare data. Open analytics framework seamlessly combines the most innovative methods, technology developments and analytics in one platform. Superior security: ISO 27001 certified and GDPR and HIPAA compliant. A complete product portfolio allows modern healthcare systems to fully embrace personalized medicine. Scalable deployments allow for a robust start and large-scale healthcare operation. Our unique toolbox enables faster translation of research insights into clinical practice. Our unique toolbox helps reduce risk, increase your pipeline value, and advance enterprise data strategy. We remove the barriers to data access and enable rapid insight generation.

adWATCH – AE assists pharmaceutical companies to report adverse events that may occur during clinical trials. adWATCH – AE provides a quick and efficient way for a reporter at a clinic or hospital to generate and manage Adverse Event Reports (AERs), and report to regulatory agencies and government agencies. A negative or dangerous effect is one that a patient experiences due to the use of drugs or medical devices. Adverse event reporting involves the tracking of all medical complaint cases. This allows for the generation of MedWatch reports, CIOMS and additional reports for management. adWATCH – AE allows researchers, physician-investigators, Contract Research Organizations, clinical trial specialists, and other healthcare professionals to create and file AERs in FDA mandated MedWatch or CIOMS format.

YASARA, a molecular modeling, simulation, and modeling program for Windows, Linux and MacOS, was developed in 1993. It makes it easy to answer all your questions. YASARA offers a user-friendly interface, photorealistic graphics and support for affordable virtual realities headsets, shutter glasses and autostereoscopic displays. This allows you to concentrate on your goal and not the details of the program. YASARA is powered with PVL (Portable Vector Language), a brand new development framework that delivers superior performance to traditional software. PVL allows you visualize even the largest proteins. It also enables interactive real-time simulations using highly accurate force fields on standard computers, making use of GPUs when possible. Dynamic models allow you to push and pull molecules and can be used instead of static photos.

We are a biotechnology company in clinical stage. We decode biology by integrating technological innovations across biology and chemistry to industrialize drug discovery. CRISPR genome editing and synthetic Biology allow for greater control over biology. Advanced robotics allows for reliable automation of complex laboratory research on an unprecedented scale. Neural network architectures allow for iterative analysis and inference from large, complex, in-house data sets. Cloud solutions increase the flexibility of high-performance computation. To build a next-generation biopharmaceutical business, we are using new technology to create virtuous learning cycles around datasets. A synchronized combination hardware, software, and data that is used to industrialize drug discovery. Redefining the traditional drug discovery process. One of the most extensive, broadest, and deepest pipelines in any technology-enabled drug company.

Fatigue Essentials is a desktop program that can be used to efficiently perform structural fatigue analysis. Fatigue Essentials is a user-friendly program that allows you to conduct stress-life analyses using either classical stress calculations or linked to FEMAP™, and using the finite element-generated stresses. The program follows a tree structure to guide users through the analysis. The following load, material, and spectrum branches provide general options for analysis. There are options for input methods and variations within each branch. Analyses results can be viewed on-screen and used to create reports or damage contour plots in FEMAP. Covers most engineering requirements. Classic mode with user input stress. Professional mode (FEMAP-linked). This mode allows you to read nodal stress and push back results in damage contour plots. You can choose to either input stress and cycles interactively or file input.

Ascalaph Designer is a general purpose program for molecular dynamics simulations. All the molecular dynamics methods can be implemented in a single graphical environment. Molecular geometry optimization using conjugate gradient methods. Displays molecular models in separate window. Two cameras are installed in each window. This allows the model to be viewed simultaneously from both sides and in different graphic modes. Drag the splitter located in the right corner to open the subwindow. Clicking on an atom/bond with the left mouse button changes their color. A brief description of the object is displayed in the status bar. Large molecules, especially proteins, can be drawn in wireframes. This style allows for fast drawing. CPK wire frame combines all the above properties.

Easy-wire mode allows you to connect elements with less clicks, and therefore less frustration. The unit-aware evaluation of expressions allows you to plot arbitrary signals, such as differential or power dissipation. You can design and analyze circuits faster with in-browser simulation. This allows you to test your circuit before you ever pick up a soldering tool. Advanced simulation capabilities include frequency domain (small signal simulation), stepping circuit parameters across a range, arbitrary Laplace function blocks, etc. With configurable plotting window, vertical and horizontal marker, and calculations for signals, you can work with multiple signals with ease. With just a few mouse clicks, you can create generic rectangular symbols to represent IC or system level wiring diagrams.

CoPlot Version 6.45 can be used to create publication-quality 2D or 3D scientific graphs. These graphs plot data and equations, maps, and technical drawings. CoPlot was designed with one goal in mind: to make a program so flexible that engineers and scientists can get exactly what they need. CoPlot also includes CoStat, which is used to handle data and provide statistics. CoPlot's flexible drawing objects allow you to create precise technical drawings. CoPlot is great for creating field maps, genetic maps, flow charts and chemical structures. Check out the samples. Text in graphs and drawing objects can include HTML-like text formatting tags, and over 1000 special characters. Create amazing scientific graphs and maps. CoPlot offers seven types of graphs, more than 40 ways to plot data, 18 ways for equations to be plotted, flexible attributes, asymmetrical and horizontal error bars, 12 axis types, and many other features.

XbarR, Individuals, and XbarS. After charts are created, update them. Identify outliers and display them without affecting the control limiits. Histogram, Capability Analysis, (Cpk), Scatter Plot with regression fitting, Pareto, Dot Plots and Box Plots Multiple Regression, Hypothesis Testing. Confidence Intervals and Sample Size Calculations. Measurement System Analysis (Gage R&R), for Quantitative and Binomial data, Cause and Effect Diagrams, Main Effects Plots and Cusum, Product Capability and FMEA and Distribution Calculators.

One animated circuit is equivalent to a thousand equations or diagrams. The schematic is accompanied by animations of voltages and currents. This gives a great insight into the operation of the circuit. The real-time simulation engine was custom-built to be fast and interactive. Simulate everything from simple logic gates and resistors to complex transistor-level designs and mixed-signal circuits with just one click. You can adjust potentiometers and LED current-limiting resistors while the simulation is running. Your changes will be reflected in real-time. The mini-waveforms that appear on top of the schematic wires are different for digital and analogue signals. Digital wires are color coded, while constant analog voltages are shown in numbers. In the XY mode, any pair of time domain signals can be plotted. The grid ticks and oscilloscope scale are automatically updated to convenient values when the data changes.

Loupe Browser is an intuitive visualization software that allows you to explore and analyze 10x Genomics Chromium or Visium data. LoupeR can convert Seurat objects to Loupe Browser files. The Loupe Browser interface's navigation and interactive features are based on a dataset of lung squamous-cell carcinoma. The workspace is centered on the view panel, where single points representing barcodes of cells are shown in different projections. Each point represents a barcode. The vast majority of them correspond to a cell. The default projection, created by the Cell Ranger pipeline, is the tSNE plot. Other projections are also available. You can move the plot by dragging the mouse over cells. Zoom in and out using the mouse wheel or trackpad. Cluster labels will appear as you move the mouse over the plot. This is useful for data with a large number of precomputed groups.

Maple Flow is a mathematical tool that allows engineers to easily brainstorm, develop and document their design calculations. Maple Flow combines a simple, intuitive interface with a powerful math engine. It provides a whiteboard-style environment where users can refine, reposition and develop their work. You can do calculations, create documentation, and refine your work in an environment that doesn't feel like a program or spreadsheet. Maple Flow organizes everything behind the scenes. You can place math, text, images or plots wherever and reposition your work using the mouse or keyboard. Maple Flow has all the features technical professionals need in a calculator tool. It includes fast solvers and built-in units tracking. Flexible plots are also included.

Renishaw's MODUS provides a powerful platform to measure 5-axis. A configurable interface allows native DMIS to be developed off-line, drawing geometry, embedded measurements, and tolerance data directly from CAD. Full simulation is also possible. The software contains algorithms that are certified for feature measurement, feature creation, and part alignment. The software allows offline creation of programs directly from CAD, with on-screen probe paths verification. The CMM environment, fixture, and location of the part can be defined to enable full simulation of 5-axis measurements programs. This reduces CMM downtime, as the programs are ready to run when they arrive at the machine. MODUS has a wide range of reporting capabilities, including CMM text reports that can be formatted in any way you like. Graphical reporting allows results to be displayed on the CAD model. This includes whisker charts or 3-D form plotting.

Compatible with uml 2.X standard diagrams and metamodels: class, object and use case, component and deployment, composite structure, sequence and communication, statechart and activity, timing, interaction, overflow, information flow, profile diagram. Support for modeling with sysml charts: requirement, block definitions, internal blocks, and parametric diagrams. Retina (High DPI) Display Support. All diagrams, text and icons are sharp and can be exported as High-DPI images (PNG or JPEG). Easy discovery and installation of third-party extensions. Many extensions are open-source and hosted on Github. Make your own extensions by re-purposing one. Quick Edit supports many shorthands to create elements and relationships in one go, such as sub-classes and supporting interfaces.