Abner Li reports via 9to5Google: Google today detailed its research into audioplethysmography (APG) that adds heart rate sensing capabilities to active noise canceling (ANC) headphones and earbuds "with a simple software upgrade." Google says the "ear canal [is] an ideal location for health sensing" given that the deep ear artery "forms an intricate network of smaller vessels that extensively permeate the auditory canal."

This audioplethysmography approach works by "sending a low intensity ultrasound probing signal through an ANC headphone's speakers. This signal triggers echoes, which are received via on-board feedback microphones. We observe that the tiny ear canal skin displacement and heartbeat vibrations modulate these ultrasound echoes." A model that Google created works to process that feedback into a heart rate reading, as well as heart rate variability (HRV) measurement. This technique works even with music playing and "bad earbuds seals." However, it was impacted by body motion, and Google countered with a multi-tone approach that serves as a calibration tool to "find the best frequency that measures heart rate, and use only the best frequency to get high-quality pulse waveform."

Google performed two sets of studies with 153 people that found APG "achieves consistently accurate heart rate (3.21% median error across participants in all activity scenarios) and heart rate variability (2.70% median error in inter-beat interval) measurements." Compared to existing HR sensors, it's not impacted by skin tones. Ear canal size and "sub-optimal seal conditions" also do not impact accuracy. Google believes this is a better approach than putting traditional photoplethysmograms (PPG) and electrocardiograms (ECG) sensors, as well as a microcontroller, in headphones/earbuds: "this sensor mounting paradigm inevitably adds cost, weight, power consumption, acoustic design complexity, and form factor challenges to hearables, constituting a strong barrier to its wide adoption."

Dan Goodin reports via Ars Technica: Three years ago, Apple introduced a privacy-enhancing feature that hid the Wi-Fi address of iPhones and iPads when they joined a network. On Wednesday, the world learned that the feature has never worked as advertised. Despite promises that this never-changing address would be hidden and replaced with a private one that was unique to each SSID, Apple devices have continued to display the real one, which in turn got broadcast to every other connected device on the network. [...]

In 2020, Apple released iOS 14 with a feature that, by default, hid Wi-Fi MACs when devices connected to a network. Instead, the device displayed what Apple called a "private Wi-Fi address" that was different for each SSID. Over time, Apple has enhanced the feature, for instance, by allowing users to assign a new private Wi-Fi address for a given SSID. On Wednesday, Apple released iOS 17.1. Among the various fixes was a patch for a vulnerability, tracked as CVE-2023-42846, which prevented the privacy feature from working. Tommy Mysk, one of the two security researchers Apple credited with discovering and reporting the vulnerability (Talal Haj Bakry was the other), told Ars that he tested all recent iOS releases and found the flaw dates back to version 14, released in September 2020. "From the get-go, this feature was useless because of this bug," he said. "We couldn't stop the devices from sending these discovery requests, even with a VPN. Even in the Lockdown Mode."

When an iPhone or any other device joins a network, it triggers a multicast message that is sent to all other devices on the network. By necessity, this message must include a MAC. Beginning with iOS 14, this value was, by default, different for each SSID. To the casual observer, the feature appeared to work as advertised. The "source" listed in the request was the private Wi-Fi address. Digging in a little further, however, it became clear that the real, permanent MAC was still broadcast to all other connected devices, just in a different field of the request. Mysk published a short video showing a Mac using the Wireshark packet sniffer to monitor traffic on the local network the Mac is connected to. When an iPhone running iOS prior to version 17.1 joins, it shares its real Wi-Fi MAC on port 5353/UDP.

IFTTT in a blog post said that Amazon is removing the service from Alexa beginning October 31st. "Once the integration is severed, users won't be able to ask Alexa to trigger IFTTT applets," reports The Verge. "Certain automations will stick around in the IFTTT app, but some will be archived on November 1st unless you take action." From the report: If your IFTTT applets use a specific phrase or question as the trigger ("Alexa, trigger..." or "Alexa, what's on my to-do list?"), that will convert to using an IFTTT button widget that you can either use in the app or add to your smartphone's homescreen. But all other triggers set up through Alexa -- say, an automation that runs when you add something to your to-do list -- will be archived. You will also have to remove any Alexa ingredients from your applets or they'll stop working.

IFTTT suggests a few alternatives to pursue to keep using it. In addition to button widgets, users can try Apple Shortcuts or the IFTTT note widget. It's also still integrated with Google Assistant, though voice commands have to start with "activate" before an applet will trigger.

AMD has taken down the latest version of its AMD Adrenalin Edition graphics driver after Counter-Strike 2-maker Valve warned that players using its Anti-Lag+ technology would result in a ban under Valve's anti-cheat rules. From a report: AMD first introduced regular Anti-Lag mitigation in its drivers back in 2019, limiting input lag by reducing the amount of queued CPU work when the processor was getting too far ahead of the GPU frame processing. But the newer Anti-Lag+ system -- which was first rolled out for a handful of games last month -- updates this system by "applying frame alignment within the game code itself," according to AMD. That method leads to additional lag reduction of up to 10 ms, according to AMD's data. That additional lag reduction could offer players a bit of a competitive advantage in these games (with the usual arguments about whether that advantage is "unfair" or not). But it's Anti-Lag+'s particular method of altering the "game code itself" that sets off warning bells for the Valve Anti-Cheat (VAC) system. After AMD added Anti-Lag+ support for Counter-Strike 2 in a version 23.10.1 update last week, VAC started issuing bans to unsuspecting AMD users that activated the feature.

"AMD's latest driver has made their 'Anti-Lag/+' feature available for CS2, which is implemented by detouring engine dll functions," Valve wrote on social media Friday. "If you are an AMD customer and play CS2, DO NOT ENABLE ANTI-LAG/+; any tampering with CS code will result in a VAC ban." Beyond Valve, there are also widespread reports of Anti-Lag+ triggering crashes or account bans in competitive online games like Modern Warfare 2 and Apex Legends. But Nvidia users haven't reported any similar problems with the company's Reflex system, which uses SDK-level code adjustments to further reduce input lag in games including Counter-Strike 2.

Sony is officially launching its portable PlayStation later this year, the PlayStation Portal remote player. The handheld device will stream PS5 games over Wi-Fi and features an eight-inch LCD screen running at 1080p resolution at 60fps. Sony says the PlayStation Portal will be available later this year priced at $199.99. From a report: "PlayStation Portal will connect remotely to your PS5 over Wi-Fi, so you'll be able to swiftly jump from playing on your PS5 to your PlayStation Portal," says Hideaki Nishino, senior vice president of platform experience at Sony Interactive Entertainment. "PlayStation Portal can play supported games that are installed on your PS5 console and use the Dualsense controller." The PlayStation Portal features prominent controllers on each side that look very much like Sony's PS5 DualSense controllers. They support adaptive triggers and haptic feedback, so PS5 games will feel similar to using a dedicated DualSense controller. The PlayStation Portal will also be capable of playing media, as the homescreen has a dedicated section for it as it's mirroring your PS5. You won't be able to run anything locally though, so if you don't have Wi-Fi then you're out of luck.

An anonymous reader quotes a report from ABC News: Alpha-gal syndrome (AGS) is a serious, potentially life-threatening allergic reaction that arises after people eat red meat or consume products with alpha-gal, a type of sugar found in most mammals, the CDC says. The syndrome is typically caused by a bite from the lone star tick, which transfers alpha-gal into the victim's body which in turn triggers an immune system response. The CDC says the number of AGS cases are underdiagnosed in the U.S. and -- despite the spread of the condition -- many clinicians aren't even aware it exists, let alone how to diagnose it. Between 2010 and 2022, there were more than 110,000 cases of AGS identified, according to the CDC.

The agency estimates the actual number of cases may be as high as 450,000 but notes the syndrome is underdiagnosed due to factors including that diagnosis requires a test, some providers are not familiar with AGS and some people with symptoms don't get tested. AGS symptoms can include hives or itchy rash, nausea or vomiting, heartburn or indigestion, diarrhea, shortness of breath, and severe stomach pain. Symptoms can range from mild to severe and typically occur two to six hours after consuming products with alpha-gal. [...] From 2010 to 2018, more than 34,000 suspected cases were identified. However, over the 2017-2022 study period, some 357,000 tests were submitted, resulting in just over 90,000 positive results. The number of new cases increased by about 15,000 each year during the five-year study period, with most cases occurring in the Southern, Midwestern, and Mid-Atlantic U.S., the CDC found. "Alpha-gal syndrome is an important emerging public health problem, with potentially severe health impacts that can last a lifetime for some patients," Dr. Ann Carpenter, and epidemiologist and lead author of one of the CDC studies, said in a statement.

"It's critical for clinicians to be aware of AGS so they can properly evaluate, diagnose, and manage their patients and also educate them on tick-bite prevention to protect patients from developing this allergic condition," she added.

We already have automated processes that detect bugs, test solutions, and generate documentation, notes a new post on Stack Overflow's blog. But beyond that, several developers "have written in the past on the idea of self-healing code. Head over to Stack Overflow's CI/CD Collective and you'll find numerous examples of technologists putting this ideas into practice."

Their blog post argues that self-healing code "is the future of software development." When code fails, it often gives an error message. If your software is any good, that error message will say exactly what was wrong and point you in the direction of a fix. Previous self-healing code programs are clever automations that reduce errors, allow for graceful fallbacks, and manage alerts. Maybe you want to add a little disk space or delete some files when you get a warning that utilization is at 90% percent. Or hey, have you tried turning it off and then back on again?

Developers love automating solutions to their problems, and with the rise of generative AI, this concept is likely to be applied to both the creation, maintenance, and the improvement of code at an entirely new level... "People have talked about technical debt for a long time, and now we have a brand new credit card here that is going to allow us to accumulate technical debt in ways we were never able to do before," said Armando Solar-Lezama, a professor at the Massachusetts Institute of Technology's Computer Science & Artificial Intelligence Laboratory, in an interview with the Wall Street Journal. "I think there is a risk of accumulating lots of very shoddy code written by a machine," he said, adding that companies will have to rethink methodologies around how they can work in tandem with the new tools' capabilities to avoid that.
Despite the occasional "hallucination" of non-existent information, Stack Overflow's blog acknowledges that large-language models improve when asked to review their response, identify errors, or show its work.

And they point out the project manager in charge of generative models at Google "believes that some of the work of checking the code over for accuracy, security, and speed will eventually fall to AI." Google is already using this technology to help speed up the process of resolving code review comments. The authors of a recent paper on this approach write that, "As of today, code-change authors at Google address a substantial amount of reviewer comments by applying an ML-suggested edit. We expect that to reduce time spent on code reviews by hundreds of thousands of hours annually at Google scale. Unsolicited, very positive feedback highlights that the impact of ML-suggested code edits increases Googlers' productivity and allows them to focus on more creative and complex tasks...."

Recently, we've seen some intriguing experiments that apply this review capability to code you're trying to deploy. Say a code push triggers an alert on a build failure in your CI pipeline. A plugin triggers a GitHub action that automatically send the code to a sandbox where an AI can review the code and the error, then commit a fix. That new code is run through the pipeline again, and if it passes the test, is moved to deploy... Right now his work happens in the CI/CD pipeline, but [Calvin Hoenes, the plugin's creator] dreams of a world where these kind of agents can help fix errors that arise from code that's already live in the world. "What's very fascinating is when you actually have in production code running and producing an error, could it heal itself on the fly?" asks Hoenes...

For now, says Hoenes, we need humans in the loop. Will there come a time when computer programs are expected to autonomously heal themselves as they are crafted and grown? "I mean, if you have great test coverage, right, if you have a hundred percent test coverage, you have a very clean, clean codebase, I can see that happening. For the medium, foreseeable future, we probably better off with the humans in the loop."
Last month Stack Overflow themselves tried an AI experiment that helped users to craft a good title for their question.

Louise Lerner writes via Phys.Org: Inside a lab, scientists marvel at a strange state that forms when they cool down atoms to nearly absolute zero. Outside their window, trees gather sunlight and turn them into new leaves. The two seem unrelated -- but a new study from the University of Chicago suggests that these processes aren't so different as they might appear on the surface. The study, published in PRX Energy on April 28, found links at the atomic level between photosynthesis and exciton condensates -- a strange state of physics that allows energy to flow frictionlessly through a material. The finding is scientifically intriguing and may suggest new ways to think about designing electronics, the authors said.

When a photon from the sun strikes a leaf, it sparks a change in a specially designed molecule. The energy knocks loose an electron. The electron, and the "hole" where it once was, can now travel around the leaf, carrying the energy of the sun to another area where it triggers a chemical reaction to make sugars for the plant. Together, that traveling electron-and-hole-pair is referred to as an "exciton." When the team took a birds-eye view and modeled how multiple excitons move around, they noticed something odd. They saw patterns in the paths of the excitons that looked remarkably familiar. In fact, it looked very much like the behavior in a material that is known as a Bose-Einstein condensate, sometimes known as "the fifth state of matter." In this material, excitons can link up into the same quantum state -- kind of like a set of bells all ringing perfectly in tune. This allows energy to move around the material with zero friction. (These sorts of strange behaviors intrigue scientists because they can be the seeds for remarkable technology -- for example, a similar state called superconductivity is the basis for MRI machines).

According to the models [...], the excitons in a leaf can sometimes link up in ways similar to exciton condensate behavior. This was a huge surprise. Exciton condensates have only been seen when the material is cooled down significantly below room temperature. It'd be kind of like seeing ice cubes forming in a cup of hot coffee. "Photosynthetic light harvesting is taking place in a system that is at room temperature and what's more, its structure is disordered -- very unlike the pristine crystallized materials and cold temperatures that you use to make exciton condensates," explained [study co-author Anna Schouten]. This effect isn't total -- it's more akin to "islands" of condensates forming, the scientists said. "But that's still enough to enhance energy transfer in the system," said Sager-Smith. In fact, their models suggest it can as much as double the efficiency. The findings open up some new possibilities for generating synthetic materials for future technology, said study co-author Prof. David Mazziotti. "A perfect ideal exciton condensate is sensitive and requires a lot of special conditions, but for realistic applications, it's exciting to see something that boosts efficiency but can happen in ambient conditions."

An anonymous reader quotes a report from the Guardian: Millions of lives could be saved by a groundbreaking set of new vaccines for a range of conditions including cancer, experts have said. A leading pharmaceutical firm said it is confident that jabs for cancer, cardiovascular and autoimmune diseases, and other conditions will be ready by 2030. Studies into these vaccinations are also showing "tremendous promise", with some researchers saying 15 years' worth of progress has been "unspooled" in 12 to 18 months thanks to the success of the Covid jab.

Dr Paul Burton, the chief medical officer of pharmaceutical company Moderna, said he believes the firm will be able to offer such treatments for "all sorts of disease areas" in as little as five years. The firm, which created a leading coronavirus vaccine, is developing cancer vaccines that target different tumor types. Burton said: "We will have that vaccine and it will be highly effective, and it will save many hundreds of thousands, if not millions of lives. I think we will be able to offer personalized cancer vaccines against multiple different tumor types to people around the world."

He also said that multiple respiratory infections could be covered by a single injection -- allowing vulnerable people to be protected against Covid, flu and respiratory syncytial virus (RSV) -- while mRNA therapies could be available for rare diseases for which there are currently no drugs. Therapies based on mRNA work by teaching cells how to make a protein that triggers the body's immune response against disease. Burton said :"I think we will have mRNA-based therapies for rare diseases that were previously undruggable, and I think that 10 years from now, we will be approaching a world where you truly can identify the genetic cause of a disease and, with relative simplicity, go and edit that out and repair it using mRNA-based technology." But scientists warn that the accelerated progress, which has surged "by an order of magnitude" in the past three years, will be wasted if a high level of investment is not maintained.

More countries shut down the internet in 2022 than ever before, according to a new report by digital rights researchers, as the threat of "digital authoritarianism" races up the agenda of many governments worldwide. From a report: Authorities in 35 countries instituted internet shutdowns at least 187 times, according to the New York-based digital rights watchdog Access Now. Nearly half of these shutdowns occurred in India, and if that nation is excluded, 2022 saw the most number of shutdowns globally since the group began monitoring disruptions in 2016. Access Now relied on technical assessments as well as news articles and personal accounts to compile its report, which spans complete blackouts, suspensions of specific phone networks or social media apps, and the slowing down of internet speeds.

Triggers for shutdowns have included large protests, conflict situations, elections and even examinations. Whatever the situation, they make it substantially more difficult for people to communicate and receive or send news, and they incur significant economic costs, which prompted the United Nations last year to call for governments to avoid using such a blunt tactic. "This can be a big warning sign of how the human rights situation is deteriorating, and shutdowns are often associated with increased levels of insecurity and other restrictions," said Liz Throssell, a spokeswoman at the U.N. Human Rights Office in Geneva. India is the most prolific at suspending the internet, topping Access Now's list for the fifth year in a row.

Researchers at Linkoping, Lund and Gothenburg universities in Sweden have successfully grown electrodes in living tissue using the body's molecules as triggers. The result, published in the journal Science, paves the way for the formation of fully integrated electronic circuits in living organisms. Phys.Org reports: Linking electronics to biological tissue is important to understanding complex biological functions, combating diseases in the brain, and developing future interfaces between man and machine. However, conventional bioelectronics, developed in parallel with the semiconductor industry, have a fixed and static design that is difficult, if not impossible, to combine with living biological signal systems. To bridge this gap between biology and technology, researchers have developed a method for creating soft, substrate-free, electronically conductive materials in living tissue. By injecting a gel containing enzymes as the "assembly molecules," the researchers were able to grow electrodes in the tissue of zebrafish and medicinal leeches.

"Contact with the body's substances changes the structure of the gel and makes it electrically conductive, which it isn't before injection. Depending on the tissue, we can also adjust the composition of the gel to get the electrical process going," says Xenofon Strakosas, researcher at LOE and Lund University and one of the study's main authors. The body's endogenous molecules are enough to trigger the formation of electrodes. There is no need for genetic modification or external signals, such as light or electrical energy, which has been necessary in previous experiments. The Swedish researchers are the first in the world to succeed in this.

In their study, the researchers further show that the method can target the electronically conducting material to specific biological substructures and thereby create suitable interfaces for nerve stimulation. In the long term, the fabrication of fully integrated electronic circuits in living organisms may be possible. In experiments conducted at Lund University, the team successfully achieved electrode formation in the brain, heart, and tail fins of zebrafish and around the nervous tissue of medicinal leeches. The animals were not harmed by the injected gel and were otherwise not affected by the electrode formation. One of the many challenges in these trials was to take the animals' immune system into account.

"A group of Stanford University professors is pushing to end a system that allows students to anonymously report classmates for exhibiting discrimination or bias, saying it threatens free speech on campus (Warning: source paywalled; alternative source)," reports the Wall Street Journal. The Daily Beast reports: Last month, a screenshot of a student reading Hitler's manifesto Mein Kampf was reported in the system, according to the Stanford Daily. Faculty members leading the charge to shut the system down say they didn't know it even existed until they read the student newspaper, one comparing the system to "McCarthyism."

Launched in 2021, students are encouraged to report incidents in which they felt harmed, which triggers a voluntary inquiry of both the student who filed the report and the alleged perpetrator. Seventy-seven faculty members have signed a petition calling on the school to investigate in hopes they toss the system out. This comes as a larger movement by Speech First, a group who claim colleges are rampant with censorship, has filed suit against several universities for their bias reporting systems.

The development team behind the open-source password management software KeePass is disputing what is described as a newly found vulnerability that allows attackers to stealthily export the entire database in plain text. BleepingComputer reports: KeePass is a very popular open-source password manager that allows you to manage your passwords using a locally stored database, rather than a cloud-hosted one, such as LastPass or Bitwarden. To secure these local databases, users can encrypt them using a master password so that malware or a threat actor can't just steal the database and automatically gain access to the passwords stored within it. The new vulnerability is now tracked as CVE-2023-24055, and it enables threat actors with write access to a target's system to alter the KeePass XML configuration file and inject a malicious trigger that would export the database, including all usernames and passwords in cleartext. The next time the target launches KeePass and enters the master password to open and decrypt the database, the export rule will be triggered, and the contents of the database will be saved to a file the attackers can later exfiltrate to a system under their control. However, this export process launches in the background without the user being notified or KeePass requesting the master password to be entered as confirmation before exporting, allowing the threat actor to quietly gain access to all of the stored passwords. [...]

While the CERT teams of Netherlands and Belgium have also issued security advisories regarding CVE-2023-24055, the KeePass development team is arguing that this shouldn't be classified as a vulnerability given that attackers with write access to a target's device can also obtain the information contained within the KeePass database through other means. In fact, a "Security Issues" page on the KeePass Help Center has been describing the "Write Access to Configuration File" issue since at least April 2019 as "not really a security vulnerability of KeePass." If the user has installed KeePass as a regular program and the attackers have write access, they can also "perform various kinds of attacks." Threat actors can also replace the KeePass executable with malware if the user runs the portable version.

"In both cases, having write access to the KeePass configuration file typically implies that an attacker can actually perform much more powerful attacks than modifying the configuration file (and these attacks in the end can also affect KeePass, independent of a configuration file protection)," the KeePass developers explain. "These attacks can only be prevented by keeping the environment secure (by using an anti-virus software, a firewall, not opening unknown e-mail attachments, etc.). KeePass cannot magically run securely in an insecure environment." If the KeePass devs don't release a version of the app that addresses this issue, BleepingComputer notes "you could still secure your database by logging in as a system admin and creating an enforced configuration file."

"This type of config file takes precedence over settings described in global and local configuration files, including new triggers added by malicious actors, thus mitigating the CVE-2023-24055 issue."

sciencehabit shares a report from Science Magazine: Triple threat. Tripledemic. A viral perfect storm. These frightening phrases have dominated recent headlines as some health officials, clinicians, and scientists forecast that SARS-CoV-2, influenza, and respiratory syncytial virus (RSV) could surge at the same time in Northern Hemisphere locales that have relaxed masking, social distancing, and other COVID-19 precautions. But a growing body of epidemiological and laboratory evidence offers some reassurance: SARS-CoV-2 and other respiratory viruses often "interfere" with each other. Although waves of each virus may stress emergency rooms and intensive care units, the small clique of researchers who study these viral collisions say there is little chance the trio will peak together and collectively crash hospital systems the way COVID-19 did at the pandemic's start.

"Flu and other respiratory viruses and SARS-CoV-2 just don't get along very well together," says virologist Richard Webby, an influenza researcher at St. Jude Children's Research Hospital. "It's unlikely that they will circulate widely at the same time." "One virus tends to bully the others," adds epidemiologist Ben Cowling at the University of Hong Kong School of Public Health. During the surge of the highly transmissible Omicron variant of SARS-CoV-2 in Hong Kong in March, Cowling found that other respiratory viruses "disappeared ... and they came back again in April." When a respiratory virus sweeps through a community, interferons can broadly raise the body's defenses and temporarily erect a populationwide immune barrier against subsequent viruses that target the respiratory system. "Basically, every virus triggers the interferon response to some extent, and every virus is susceptible to it," says immunologist Ellen Foxman at Yale University, who has been exploring interference between SARS-CoV-2 and other viruses in a laboratory model of the human airway. Rhinoviruses, which cause common colds, can trip up influenza A (the most prevalent flu virus). RSV can bump rhinoviruses and human metapneumoviruses. Influenza A can thwart its distant cousin influenza B. "There are a lot of major health implications from viral interference," says Guy Boivin, a virologist at Laval University who co-authored a review (PDF) on viral interference earlier this year.

Now, viral interference researchers are closely watching the newest respiratory virus to circle the globe. "What interactions could SARS-CoV-2 have with other viruses?" Murcia asks. "To this day, there are no robust epidemiological data." For one thing, the widespread social distancing and mask wearing in many countries meant there was little chance to see interference in action. "There was almost no circulation of other respiratory viruses during the first 3 years of the pandemic," Boivin says. Also, SARS-CoV-2 has many defenses against interferons, including preventing their production, which might affect its interactions with other viruses. Still, Foxman has published evidence that, in her organoid model, rhinovirus can interfere with SARS-CoV-2. And Boivin's team has reported (PDF) that influenza A and SARS-CoV-2 each can block the other in cell studies.

An anonymous reader quotes a report from SciTechDaily: ISRIB, a tiny molecule identified by the University of California, San Francisco (UCSF) researchers can repair the neural and cognitive effects of concussion in mice weeks after the damage, according to a new study. ISRIB blocks the integrated stress response (ISR), a quality control process for protein production that, when activated chronically, can be harmful to cells. The study, which was recently published in the Proceedings of the National Academy of Sciences, discovered that ISRIB reverses the effects of traumatic brain injury (TBI) on dendritic spines, an area of neurons vital to cognition. The drug-treated mice also showed sustained improvements in working memory.

The authors suggest that TBI triggers a persistent activation of the ISR, which in turn leads to the ongoing proliferation of transient spines that fail to support memory formation. Future experiments will explore whether ISRIB has similar effects on other cell types, brain areas, and cognitive tasks. ISR activation has been implicated in many neurological disorders, including Alzheimer's disease, Parkinson's disease, multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS). Thus, the researchers believe ISRIB may have therapeutic potential in multiple patient populations. While there was no evidence of the drug's toxicity in mice, clinical trials are currently evaluating the safety and effectiveness of ISRIB in humans.

"First they came for factory jobs. Then they showed up in service industries. Now, machines are making inroads into the kind of white-collar office work once thought to be the exclusive preserve of humans," write Alexandre Tanzi and Reade Pickert via Bloomberg. An anonymous reader shares an excerpt from the report: It's not just corporate giants, capable of spending millions of dollars to develop their own technologies, that are getting in on the act. One feature of the new automation wave is that companies like Kizen have popped up to make it affordable even for smaller firms. Based in Austin, Texas, Kizen markets an automated assistant called Zoe, which can perform tasks for sales teams like carrying out initial research and qualifying leads. Launched a year ago, it's already sold more than 400,000 licenses. "Our smallest customer pays us $10 a month and our largest customer pays us $9.5 million a year,'' says John Winner, Kizen's chief executive officer. There are plenty of other ambitious companies cashing in on the trend, and posting steep increases in revenue -- like UiPath Inc., a favorite of star investment manager Cathie Wood, as well as Appian Corp. and EngageSmart Inc. Alongside the growth of AI and what economists call "robotic process automation" -- essentially, when software performs certain tasks previously done by humans -- old-school automation is still going strong too.

The number of robots sold in North America hit a new record in the first quarter of 2022, according to the Association for Advancing Automation. The World Economic Forum predicts that by 2025, machines will be working as many hours as humans. What all of this innovation means for the world's workers is one of the key open questions in economics. The upbeat view says it's tasks that get automated, not entire jobs -- and if the mundane ones can be handled by computers or robots, that should free up employees for more challenging and satisfying work. The downside risk: occupations from sales reps to administrative support, could begin to disappear -- without leaving obvious alternatives for the people who earned a living from them. That adds another employment threat for white-collar workers who may already be vulnerable right now to an economic downturn, largely because so many got hired in the boom of the past couple of years.

KC Harvey Environmental, a consultancy based in Bozeman, Montana that works with businesses and governments on environmental issues, is one of Kizen's clients. It uses the software to automate document control -- for example, archiving and delivering new contracts to the right places and people. "A new project probably took our accounting group and project management team a day," says Rio Franzman, KC Harvey's chief operating officer. "This now probably streamlines it down to about an hour." The firm employs about 100 people and "we didn't lose any'' as a result of automation, he says. "What it did allow is for the reallocation of time and resources to more meaningful tasks." KC Harvey is now working with Kizen to bring AI into its marketing, too, with a partly automated newsletter among other projects. Some of the biggest firms at the forefront of automation also say they've been able to do it without cutting jobs.

Engineering giant Siemens AG says it's automated all kinds of production and back-office tasks at its innovative plant in Amberg, Germany, where it makes industrial computers, while keeping staffing steady at around 1,350 employees over several decades. The firm has developed a technology known as "digital twinning," which builds virtual versions of everything from specific products to administrative processes. Managers can then run simulations and stress-tests to see how things can be made better. "We're not going to automate people out of the process," says Barbara Humpton, CEO of Siemens USA. "By optimizing automation systems, and by using digital tools and AI, workers have increased productivity at Amberg by more than 1,000%." [...] Whatever the outcome, it's unlikely to allay the deep unease that the idea of automation triggers among workers who feel their jobs are vulnerable. With the rise of AI, that group increasingly includes white-collar employees.

Longtime Slashdot reader root_42 writes: Remember the clicking sounds of spinning hard disks? One "problem" with retro computing is that we replace those disks with compact flash, SD cards or even SSDs. Those do not make any noises that you can hear under usual circumstances, which is partly nice because the computer becomes quieter, but also irritating because sometimes you can't tell if the computer has crashed or is still working. This little device fixes that issue! It's called the HDD Clicker and it's a very unique little gadget. "An ATtiny and a few support components ride on a small PCB along with a piezoelectric speaker," describes Hackaday. "The dongle connects to the hard drive activity light, which triggers a series of clicks from the speaker that sound remarkably like a hard drive heading seeking tracks."

A demo of the device can be viewed at 7:09, with a full defragmentation at 13:11.

People who experience frequent bad dreams in middle age may experience a faster rate of cognitive decline and be at higher risk of dementia as they get older, data suggests. If confirmed, the research could eventually lead to new ways of screening for dementia and intervention to slow the rate of decline. From a report: Most people experience bad dreams from time to time, but approximately 5% of adults experience nightmares -- dreams distressing enough to wake them up -- at least once a week. Stress, anxiety, and sleep deprivation are all potential triggers, but previous research in people with Parkinson's disease has also linked frequent distressing dreams to faster rates of cognitive decline, and an increased risk of developing dementia in the future.

To investigate whether the same might be true of healthy adults, Dr Abidemi Otaiku at the University of Birmingham turned to data from three previous studies that have examined people's sleep quality and then followed them over many years, assessing their brain health as well as other outcomes. This included more than 600 middle-aged adults (aged 35 to 64), and 2,600 people aged 79 and older. Their data was analysed using statistical software to find out whether those who experienced a higher frequency of distressing dreams were more likely to go on to experience cognitive decline and be diagnosed with dementia. The research, published in eClinicalMedicine, found that middle-aged people who experienced bad dreams at least once a week were four times more likely to experience cognitive decline over the following decade than those who rarely had nightmares. Among elderly participants, those who frequently reported distressing dreams were twice as likely to be diagnosed with dementia in subsequent years.

An anonymous reader quotes a report from Ars Technica: A Sony executive confirmed Friday that the PlayStation VR 2 will not be backward-compatible with games developed for the original PlayStation VR. Sid Shuman, senior director of content communications at Sony Interactive, asked Hideaki Nishino, senior vice president of platform experience at Sony, whether games for the original PSVR could be played on a PSVR2 kit on the Official PlayStation Podcast, episode 439 (his answer starts at 29:12). "PSVR games are not compatible with PSVR2 because PSVR2 is designed to deliver a truly next-generation VR experience," Nishino said. Nishino listed several "much more advanced features" in the VR2, including new controllers with haptic feedback, adaptive triggers, advanced eye tracking, and 3D audio. "That means developing games for PSVR2 requires a whole different approach than the original PSVR."

While the answer was emphatic -- not compatible -- and closed off any hope fans might have harbored, Nishino's checklist of new VR2 features didn't clearly explain why the system would be incapable of running less-advanced VR1 games. Consider the Oculus Rift S, which touted an entirely different eye tracking system than its predecessor, the original Oculus Rift. The Rift S maintained compatibility with games built for any Rift system (along with some games for other headsets). It was a seamless transition for those who upgraded their Rift or bought into VR at a later stage. It's also a disappointing outcome for some great games that were available only on PlayStation VR. Those include the original Mario-caliber Astro Bot, brain-twisting puzzle-game Statik, the VR mode for Resident Evil 7 that never saw release on any other system, first-party VR exclusive Blood & Truth, and a VR mode for WipEout that could only benefit from a VR2 headset.

The vaccine manufacturer Moderna sued Pfizer and BioNTech on Friday, claiming that its rivals' Covid-19 shot violates its patents protecting its groundbreaking technology. NPR reports: The lawsuit alleges the two companies used certain key features of technology Moderna developed to make their COVID-19 vaccine. It argues that Pfizer and BioNtech's vaccine infringes patents Moderna filed between 2010 and 2016 for its messenger RNA or mRNA technology.

All three companies' COVID-19 vaccines used mRNA technology which is a new way to make vaccines. In the past, vaccines were generally made using parts of a virus, or inactivated virus, to stimulate an immune response. With mRNA technology, the vaccine uses messenger RNA created in a lab to send genetic instructions that teach our cells to make a protein or part of a protein that triggers an immune response. In October 2020, Moderna pledged not to enforce its COVID-19 related patents while the pandemic was ongoing, according to a statement from the company. In March this year, it said it will stick to its commitment not to enforce its COVID-19 related patents in low and middle-income countries, but expects rival companies like Pfizer to respect its intellectual property.