For the first time, the American Psychological Association (APA) has issued guidelines for teenagers, parents, teachers and policymakers on how to use social media, with the aim of reducing the rate of depression, anxiety and loneliness in adolescents. NPR reports: The 10 recommendations in the report summarize recent scientific findings and advise actions, primarily by parents, such as monitoring teens' feeds and training them in social media literacy, even before they begin using these platforms. But some therapists and clinicians say the recommendations place too much of the burden on parents. To implement this guidance requires cooperation from the tech companies and possibly regulators.

While social media can provide opportunities for staying connected, especially during periods of social isolation, like the pandemic, the APA says adolescents should be routinely screened for signs of "problematic social media use." The APA recommends that parents should also closely monitor their children's social media feed during early adolescence, roughly ages 10-14. Parents should try to minimize or stop the dangerous content their child is exposed to, including posts related to suicide, self-harm, disordered eating, racism and bullying. Studies suggest that exposure to this type of content may promote similar behavior in some youth, the APA notes.

Another key recommendation is to limit the use of social media for comparison, particularly around beauty -- or appearance-related content. Research suggests that when kids use social media to pore over their own and others' appearance online, this is linked with poor body image and depressive symptoms, particularly among girls. As kids age and gain digital literacy skills they should have more privacy and autonomy in their social media use, but parents should always keep an open dialogue about what they are doing online. The report also cautions parents to monitor their own social media use, citing research that shows that adults' attitudes toward social media and how they use it in front of kids may affect young people.

The APA's report does contain recommendations that could be picked up by policy makers seeking to regulate the industry. For instance it recommends the creation of "reporting structures" to identify and remove or deprioritize social media content depicting "illegal or psychologically maladaptive behavior," such as self-harm, harming others, and disordered eating. It also notes that the design of social media platforms may need to be changed to take into account "youths' development capabilities," including features like endless scrolling and recommended content. It suggests that teens should be warned "explicitly and repeatedly" about how their personal data could be stored, shared and used.

For years Google published scientific research that helped jump-start its competitors. But now it's lurched into defensive mode. From a report: In February, Jeff Dean, Google's longtime head of artificial intelligence, announced a stunning policy shift to his staff: They had to hold off sharing their work with the outside world. For years Dean had run his department like a university, encouraging researchers to publish academic papers prolifically; they pushed out nearly 500 studies since 2019, according to Google Research's website. But the launch of OpenAI's groundbreaking ChatGPT three months earlier had changed things. The San Francisco start-up kept up with Google by reading the team's scientific papers, Dean said at the quarterly meeting for the company's research division. Indeed, transformers -- a foundational part of the latest AI tech and the T in ChatGPT -- originated in a Google study.

Things had to change. Google would take advantage of its own AI discoveries, sharing papers only after the lab work had been turned into products, Dean said, according to two people with knowledge of the meeting, who spoke on the condition of anonymity to share private information. The policy change is part of a larger shift inside Google. Long considered the leader in AI, the tech giant has lurched into defensive mode -- first to fend off a fleet of nimble AI competitors, and now to protect its core search business, stock price, and, potentially, its future, which executives have said is intertwined with AI. In op-eds, podcasts and TV appearances, Google CEO Sundar Pichai has urged caution on AI. "On a societal scale, it can cause a lot of harm," he warned on "60 Minutes" in April, describing how the technology could supercharge the creation of fake images and videos. But in recent months, Google has overhauled its AI operations with the goal of launching products quickly, according to interviews with 11 current and former Google employees, most of whom spoke on the condition of anonymity to share private information.

A NASA instrument to provide unprecedented resolution of monitoring major air pollutants -- down to four square miles -- lifted off on its way to geostationary orbit at 12:30 a.m. EDT Friday. The Tropospheric Emissions: Monitoring of Pollution (TEMPO) instrument will improve life on Earth by revolutionizing the way scientists observe air quality from space. From a report: "The TEMPO mission is about more than just studying pollution -- it's about improving life on Earth for all. By monitoring the effects of everything from rush-hour traffic to pollution from forest fires and volcanoes, NASA data will help improve air quality across North America and protect our planet," said NASA Administrator Bill Nelson. [...] From a fixed geostationary orbit above the equator, TEMPO will be the first space-based instrument to measure air quality over North America hourly during the daytime and at spatial regions of several square miles -- far better than existing limits of about 100 square miles in the U.S. TEMPO data will play an important role in the scientific analysis of pollution, including studies of rush hour pollution, the potential for improved air quality alerts, the effects of lightning on ozone, the movement of pollution from forest fires and volcanoes, and even the effects of fertilizer application.

TEMPO's observations will dramatically improve the scientific data record on air pollution -- including ozone, nitrogen oxide, sulfur dioxide and formaldehyde -- not only over the continental United States, but also Canada, Mexico, Cuba, the Bahamas, and part of the island of Hispaniola. "Our TEMPO slogan is 'It's about time,' which hints at TEMPO's ability to provide hourly air pollution data," said Xiong Liu, deputy principal investigator for TEMPO at the Center for Astrophysics, Harvard & Smithsonian in Cambridge, Massachusetts. "After working on the TEMPO for more than 10 years, it is about time to launch TEMPO to produce real TEMPO data and start the new era of air quality monitoring over North America."

Bruce66423 shares a report from Nature: The World Health Organization (WHO) has quietly shelved the second phase of its much-anticipated scientific investigation into the origins of the COVID-19 pandemic, citing ongoing challenges over attempts to conduct crucial studies in China, Nature has learned. Researchers say they are disappointed that the investigation isn't going ahead, because understanding how the coronavirus SARS-CoV-2 first infected people is important for preventing future outbreaks. But without access to China, there is little that the WHO can do to advance the studies, says Angela Rasmussen, a virologist at the University of Saskatchewan in Saskatoon, Canada. "Their hands are really tied." [...]

"There is no phase two," Maria Van Kerkhove, an epidemiologist at the WHO in Geneva, Switzerland, told Nature. The WHO planned for work to be done in phases, she said, but "that plan has changed." "The politics across the world of this really hampered progress on understanding the origins," she said. Researchers are undertaking some work to pin down a timeline of the virus's initial spread. This includes efforts to trap bats in regions bordering China in search of viruses closely related to SARS-CoV-2; experimental studies to help narrow down which animals are susceptible to the virus and could be hosts; and testing of archived wastewater and blood samples collected around the world in late 2019 and early 2020. But researchers say that too much time has passed to gather some of the data needed to pinpoint where the virus originated. "The ending of the investigation is not a surprise," adds Bruce66423. "But why 'quietly'?"

An anonymous reader quotes a report from The Guardian: Scientists working on an experimental anti-ageing therapy claim to have broken a record by extending the lifespan of a lab rat called Sima. Named after the Hindi word for "limit" or "boundary", Sima is the last remaining survivor from a group of rodents that received infusions of blood plasma taken from young animals to see if the treatment prolonged their lives. Sima, who was born on February 28, 2019, has lived for 47 months, surpassing the 45.5 months believed to be the oldest age recorded in scientific literature for a female Sprague-Dawley rat, the researchers say. So far, Sima has outlived her closest rival in the study by nearly six months. "We have the oldest living female Sprague Dawley rat," said Dr Harold Katcher, a former biology professor at the University of Maryland, now chief scientific officer at Yuvan Research, a California-based startup.

Researchers have rushed to produce and trial therapies based on young blood plasma after numerous experiments found that infusions could reinvigorate aging organs and tissues. But while studies have found benefits for rodents, there is no evidence to date that the somewhat vampiric approach to youthfulness will help humans dodge the passage of time, despite the best wishes of Silicon Valley. The results from Katcher's latest study will be written up when Sima dies, but data gathered so far suggests that eight rats that received placebo infusions of saline lived for 34 to 38 months, while eight that received a purified and concentrated form of blood plasma, called E5, lived for 38 to 47 months. They also had improved grip strength. Rats normally live for two to three years, though a contender for the oldest ever is a brown rat that survived on a restricted calorie diet for 4.6 years.

A patent filing on the potential therapy describes how plasma from young mammals is purified and concentrated before use. Some components, such as platelets, are removed, as they can trigger immune reactions. The patent names pigs, cows, goats, sheep and humans as possible donors. The amount of plasma needed to produce a single concentrated dose is at least as much as the recipient has in their entire body, it states. If the therapy ever shows promise in humans -- large trials are needed in more animals first -- Katcher believes the plasma could be collected from pigs at abbatoirs.

The forest carbon offsets approved by the world's leading provider and used by Disney, Shell, Gucci and other big corporations are largely worthless and could make global heating worse, according to a new investigation. The Guardian: The research into Verra, the world's leading carbon standard for the rapidly growing $2bn voluntary offsets market, has found that, based on analysis of a significant percentage of the projects, more than 90% of their rainforest offset credits -- among the most commonly used by companies -- are likely to be "phantom credits" and do not represent genuine carbon reductions.

The analysis raises questions over the credits bought by a number of internationally renowned companies -- some of them have labelled their products "carbon neutral," or have told their consumers they can fly, buy new clothes or eat certain foods without making the climate crisis worse. But doubts have been raised repeatedly over whether they are really effective. The nine-month investigation has been undertaken by the Guardian, the German weekly Die Zeit and SourceMaterial, a non-profit investigative journalism organisation. It is based on new analysis of scientific studies of Verra's rainforest schemes. It has also drawn on dozens of interviews and on-the-ground reporting with scientists, industry insiders and Indigenous communities. The findings -- which have been strongly disputed by Verra -- are likely to pose serious questions for companies that are depending on offsets as part of their net zero strategies.

An anonymous reader quotes a report from Scientific American: An artificial-intelligence (AI) chatbot can write such convincing fake research-paper abstracts that scientists are often unable to spot them, according to a preprint posted on the bioRxiv server in late December1. "I am very worried," says Sandra Wachter, who studies technology and regulation at the University of Oxford, UK, and was not involved in the research. "If we're now in a situation where the experts are not able to determine what's true or not, we lose the middleman that we desperately need to guide us through complicated topics," she adds. Researchers are divided over the implications for science. The chatbot, ChatGPT, creates realistic and intelligent-sounding text in response to user prompts. It is a 'large language model', a system based on neural networks that learn to perform a task by digesting huge amounts of existing human-generated text. Software company OpenAI, based in San Francisco, California, released the tool on November 30, and it is free to use.

Since its release, researchers have been grappling with the ethical issues surrounding its use, because much of its output can be difficult to distinguish from human-written text. Scientists have published a preprint2 and an editorial3 written by ChatGPT. Now, a group led by Catherine Gao at Northwestern University in Chicago, Illinois, has used ChatGPT to generate artificial research-paper abstracts to test whether scientists can spot them. The researchers asked the chatbot to write 50 medical-research abstracts based on a selection published in JAMA, The New England Journal of Medicine, The BMJ, The Lancet and Nature Medicine. They then compared these with the original abstracts by running them through a plagiarism detector and an AI-output detector, and they asked a group of medical researchers to spot the fabricated abstracts.

The ChatGPT-generated abstracts sailed through the plagiarism checker: the median originality score was 100%, which indicates that no plagiarism was detected. The AI-output detector spotted 66% the generated abstracts. But the human reviewers didn't do much better: they correctly identified only 68% of the generated abstracts and 86% of the genuine abstracts. They incorrectly identified 32% of the generated abstracts as being real and 14% of the genuine abstracts as being generated. Wachter says that, if scientists can't determine whether research is true, there could be "dire consequences". As well as being problematic for researchers, who could be pulled down flawed routes of investigation, because the research they are reading has been fabricated, there are "implications for society at large because scientific research plays such a huge role in our society". For example, it could mean that research-informed policy decisions are incorrect, she adds. On the contrary, Arvind Narayanan, a computer scientist at Princeton University in New Jersey, says: "It is unlikely that any serious scientist will use ChatGPT to generate abstracts." He adds that whether generated abstracts can be detected is "irrelevant."

"The question is whether the tool can generate an abstract that is accurate and compelling. It can't, and so the upside of using ChatGPT is minuscule, and the downside is significant," he says.

One of the latest trends in boutique fitness is electrifying. Literally. From a report: Called whole-body electrical muscle stimulation, or EMS, the technique requires users to wear an electrode-studded suit that attaches to a machine. The suit delivers electrical impulses that make each exercise more difficult as muscles fight against the impulses. The result is a more efficient way to build muscle mass and strength, say proponents, who claim that one 20-minute session of whole-body zapping achieves the same benefits as two and half hours of conventional strength training.

In the U.S., the workouts are offered by about 400 fitness centers, spas and other outlets, and do-it-yourself home training kits are proliferating online. Yet whole-body EMS isn't a shortcut to a Marvel hero's physique, scientists say. Regulators have warned the equipment can be dangerous, with risks including muscle damage or burns. Whole-body EMS is attracting more attention from researchers studying whether the technique might benefit people who don't or can't exercise. Some doctors are investigating whether it can decrease inflammation in the obese and frailty in older people. A small study presented at an American Heart Association conference in November suggested that whole-body EMS might benefit the heart.

Twenty-four young, healthy adults who did 20 minutes a week of squats, lunges and bicep curls using electrical stimulation recorded greater improvements in waist and hip measurements, cholesterol levels, aerobic capacity and other indicators of cardiac health than a second group that did the same exercises without stimulation, according to the findings, which haven't been published in a scientific journal. Small studies like this suggest the approach might hold promise as a supplemental treatment for cardiac patients who don't get the exercise they need, says Jaskanwal Sara, the Mayo Clinic doctor who conducted the research.

An anonymous reader quotes a report from Scientific American: Most people have two sex chromosomes, either two X's or an X and a Y, which give rise to female or male biological attributes on a spectrum. Studies suggest these chromosomes also have much broader effects, contributing to processes that include immune system function, neuronal development, disease susceptibility and reactions to drugs. But scrutinizing the specific role of X and Y chromosomes is challenging. With current tools, it is difficult to disentangle the effects of genes versus hormones, for example. Now scientists have devised a tool that could overcome this obstacle -- by generating XX and XY cells from a single person for the first time. This unique set of cells could help researchers tackle long-standing questions about how sex chromosomes affect disease and the role they play in early development.

Benjamin Reubinoff, a professor of obstetrics and gynecology at the Hadassah Medical Center in Israel, and his team began the project to overcome barriers facing investigations of sex differences in humans. Currently there are two major ones, according to Reubinoff: the difficulty of separating chromosomal and hormonal effects and the inability to pinpoint the effects of X and Y chromosomes while ruling out contributions from the rest of a person's genetic makeup. "The main reason for doing this study was the lack of a good model to study differences between males and females in humans," Reubinoff says. "There have been animal models, but a model in humans was not available." To create such a model, Reubinoff, his former M.D. and Ph.D. student Ithai Waldhorn and their colleagues first obtained white blood cells previously collected from a person with Klinefelter syndrome, a condition in which male individuals are born with an extra X chromosome. The cells came from the repositories of the Coriell Institute for Medical Research, where people donate samples for use in a wide range of biomedical research projects. The donor had a rare "mosaic" form of the condition, in which some of their cells had three sex chromosomes (XXY), some had two X chromosomes, and some had one X and one Y. The researchers reprogrammed all three cell types into induced pluripotent stem cells, which have the capacity to self-renew and to develop into neurons, muscle cells or other cell types.

Ultimately the team generated XX and XY cells that -- apart from their sex chromosomes -- were genetically identical. The researchers then conducted a series of experiments replicating findings from prior studies with other models. For example, they confirmed previously reported differences in genes that were turned on in XX or XY cells. They also coaxed their stem cells to develop into immature versions of neurons and found evidence of previously reported sex differences in early neural development. "It was reassuring to see that the model really shows differences between the sexes that were reported from other systems," Reubinoff says. The findings were published last month in Stem Cell Reports. "This is a very well-designed study that validates the notion that sex differences start early in development -- and that they depend on the sex chromosomes because that's the only thing that can account for those differences," says Nora Engel, a professor of cancer and cell biology at Temple University.

The Viking 1 lander arrived on the Martian surface 46 years ago to investigate the planet. It dropped down into what was thought to be an ancient outflow channel. Now, a team of researchers believes they've found evidence of an ancient megatsunami that swept across the planet billions of years ago, less than 600 miles from where Viking landed. Gizmodo reports: In a new paper published today in Scientific Reports, a team identified a 68-mile-wide impact crater in Mars' northern lowlands that they suspect is leftover from an asteroid strike in the planet's ancient past. "The simulation clearly shows that the megatsunami was enormous, with an initial height of approximately 250 meters, and highly turbulent," said Alexis Rodriguez, a researcher at the Planetary Science Institute and lead author of the paper, in an email to Gizmodo. "Furthermore, our modeling shows some radically different behavior of the megatsunami to what we are accustomed to imagining."

Rodriguez's team studied maps of the Martian surface and found the large crater, now named Pohl. Based on Pohl's position on previously dated rocks, the team believes the crater is about 3.4 billion years old -- an extraordinarily long time ago, shortly after the first signs of life we know of appeared on Earth. According to the research team's models, the asteroid impact could have been so intense that material from the seafloor may have dislodged and been carried in the water's debris flows. Based on the size of the crater, the team believes the impacting asteroid could have been 1.86 miles wide or 6 miles wide, depending on the amount of ground resistance the asteroid encountered. The impact could have released between 500,000 megatons and 13 million megatons of TNT energy (for comparison, the Tsar Bomba nuclear test was about 57 megatons of TNT energy.) "A clear next step is to propose a landing site to investigate these deposits in detail to understand the ocean's evolution and potential habitability," Rodriguez said. "First, we would need a detailed geologic mapping of the area to reconstruct the stratigraphy. Then, we need to connect the surface modification history to specific processes through numerical modeling and analog studies, including identifying possible mud volcanoes and glacier landforms."

Federal U.S. agencies (including the White House Office of Science and Technology Policy) have been asked to develop a five-year "scientific assessment of solar and other rapid climate interventions." As the Daily Beast sees it, the U.S. government is signalling that it's looking into "one of the most controversial and consequential climate change-fighting tactics yet," suggesting the report will look at a technique "that essentially involves spraying fine aerosols into the atmosphere to reflect sunlight away from the Earth. The idea is that, once it's reflected, there'll be less heat and temperatures will go down."

It seems like that's a subset of the "solar and other rapid climate interventions" being mentioned in the federal document. But for what it's worth, here's an official statement from the American Meteorological Society on "large-scale efforts to intentionally modify the climate system to counteract the consequences of increasing greenhouse gas concentrations.... now commonly referred to as climate intervention (also called geoengineering)..." Proposals to intervene in the climate system generally fall into two broad categories: 1) actively removing CO2 (and possibly other greenhouse gases) from the atmosphere, known as carbon dioxide removal; 2) exerting a cooling influence on Earth by reflecting sunlight (known as solar radiation management) or altering thermal emissions to space by thinning cirrus clouds. These proposals differ widely in their potential to reduce impacts, create new risks, and redistribute risks among nations.

Techniques that remove CO2 directly from the air would confer global benefits by directly addressing the source of the climate problem. However, it may not be feasible to rapidly remove CO2 at a scale that will significantly limit warming. The effects of CO2 removal approaches are not fully understood and could create adverse local and global impacts. Reflecting sunlight would reduce Earth's average surface temperature but would not offset all aspects of climate change and would produce a different set of risks than those resulting from unmitigated warming.

The American Meteorological Society recommends an accelerated and robust climate intervention research program, and associated governance framework, to inform public policies. This should not include the development of deployment platforms but needs to include study of the feasibility of different deployment scenarios and strategies and how they would affect climate risk.... The desired outcome is for society to have the best possible information in hand to assess different options for reducing the risks of climate change and to decide if actions should include intentional climate intervention. Comprehensive Earth system model simulations will play a critical role in quantifying the regional to global impacts of different climate intervention approaches.... Sustained monitoring of the Earth system and targeted field campaigns will be critical, not only to improve our understanding of key processes but for establishing an observational baseline of the system behavior prior to any intervention. Monitoring and field studies would also be needed for quantifying impacts should an intervention be implemented.

These studies will yield additional benefits in our understanding of atmospheric processes and the climate system, with implications beyond what is needed for decisions related to climate intervention, such as improved weather predictions and climate projections.

The climate crisis must be addressed by ending net emissions of greenhouse gases, and at the same time, adapting to changes already happening. While it is currently premature to either advocate for or rule out climate interventions, these decisions, when they are made, must be based on the best scientific and technical information. With this goal in mind, AMS calls for a robust program of research with a strong governance framework to assess climate interventions. Such a program should be designed to provide the knowledge base to support decisions that may need to be made within the next decade regarding the inclusion of climate intervention among our responses to global warming.
Thanks to long-time Slashdot reader cstacy for submitting the article.

An anonymous reader quotes a report from Scientific American: With a few notable exceptions -- such as during the 1918 influenza pandemic, World War II and the HIV crisis -- life expectancy in the U.S. has had gradual upward trajectory over the past century. But that progress has steeply reversed in the past two years as COVID and other tragedies have cut millions of lives short. U.S. life expectancy fell by a total of 2.7 years (PDF) between 2019 and 2021 to 76.1 years -- the lowest it has been since 1996, according to provisional data recently released by the Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS). The drop was 3.1 years for male individuals and 2.3 years for female ones. Non-Hispanic Native American and Alaska Native peoples saw the biggest decline -- a staggering 6.6 years. But every racial and ethnic group suffered: life expectancy decreased by 4.2 years in the Hispanic population, by four years in the non-Hispanic Black population, by 2.4 years in the non-Hispanic white population and by 2.1 years in the non-Hispanic Asian population.

"Basically, all the gains between 1996 and 2019 are as if they never happened," says Elizabeth Arias, director of the U.S. life table program at the NCHS and co-author of a report on the new data. COVID deaths drove much of the decline as the country grappled with the world's worst pandemic in a century. But unintentional injuries -- largely driven by drug overdoses -- also played a significant role, the data show. Increases in deaths from heart disease, chronic liver disease and suicide also contributed. "This isn't supposed to happen," says Philip Cohen, a professor of sociology at the University of Maryland, who studies demographic trends and inequality. "I think it's a wake-up call for us ... that we can't put public health on autopilot; that we don't have this invisible hand of development just raising living standards over time." The drop in life expectancy would have been even more stark if it had not been partially offset by declines in influenza and pneumonia deaths, which were likely reduced by pandemic-related precautions such as masking and social distancing.

Blue light from artificial sources is on the rise, which may have negative consequences for human health and the wider environment, according to a study. From a report: Academics at the University of Exeter have identified a shift in the kind of lighting technologies European countries are using at night to brighten streets and buildings. Using images produced by the International Space Station (ISS), they have found that the orange-coloured emissions from older sodium lights are rapidly being replaced by white-coloured emissions produced by LEDs. While LED lighting is more energy-efficient and costs less to run, the researchers say the increased blue light radiation associated with it is causing "substantial biological impacts" across the continent. The study also claims that previous research into the effects of light pollution have underestimated the impacts of blue light radiation.

Chief among the health consequences of blue light is its ability to suppress the production of melatonin, the hormone that regulates sleep patterns in humans and other organisms. Numerous scientific studies have warned that increased exposure to artificial blue light can worsen people's sleeping habits, which in turn can lead to a variety of chronic health conditions over time. The increase in blue light radiation in Europe has also reduced the visibility of stars in the night sky, which the study says "may have impacts on people's sense of nature." Blue light can also alter the behavioural patterns of animals including bats and moths, as it can change their movements towards or away from light sources.

An anonymous reader quotes a report from Phys.Org: A recent report by the United States Centers for Disease Control and Prevention found more than 80 percent of urine samples from children and adults in the U.S. contained the herbicide glyphosate. A study by Florida Atlantic University and Nova Southeastern University takes this research one step further and is the first to link the use of the herbicide Roundup, a widely used weed killer, to convulsions in animals. Glyphosate, the weed killer component in Roundup, is the world's most commonly used herbicide by volume and by land-area treated. Glyphosate-resistant crops account for almost 80 percent of transgenic crop cultivated land, which has resulted in an estimated 6.1 billion kilos of glyphosate sprayed across the world from 2005 to 2014. Roundup is used at both industrial and consumer levels, and its use is projected to dramatically increase over the coming years.A major question, yet to be fully understood, is the potential impact of glyphosate on the nervous system.

Results, published in Scientific Reports, showed that glyphosate and Roundup increased seizure-like behavior in soil-dwelling roundworms and provides significant evidence that glyphosate targets GABA-A receptors. These communication points are essential for locomotion and are heavily involved in regulating sleep and mood in humans. What truly sets this research apart is that it was done atsignificantly lesslevels than recommended by the EPA and those used in past studies. "The concentration listed for best results on the Roundup Super Concentrate label is 0.98 percent glyphosate, which is about 5 tablespoons of Roundup in 1 gallon of water," said [project lead Akshay S. Naraine]. "A significant finding from our study reveals that just 0.002 percent glyphosate, a difference of about 300 times less herbicide than the lowest concentration recommended for consumer use, had concerning effects on the nervous system."

Using C. elegans, a soil-dwelling roundworm, researchers first tested glyphosate alone and then both the U.S. and United Kingdom formulations of Roundup from two distinct time periods -- before and after the U.K.'s 2016 ban on polyethoxylated tallowamine (POEAs). These conditions were selected to pinpoint which effects are specific to the active ingredient glyphosate, Roundup formulations in general, the POEAs surfactants, or any combination of these. The study found that the active ingredient glyphosate exacerbated convulsions in C. elegans and suggest the GABA-A receptor as a neurological target for the observed physiological changes. The data also indicate that there is an important distinction between exposure to glyphosate and Roundup, with Roundup exposure increasing the percentage of C. elegans that did not recover from seizure activity. The non-recovery phenotype and prolonged convulsions in C. elegans from this study have helped to set a foundation for understanding nuanced physiological effects of herbicide that occur at concentrations exponentially below neurotoxic levels.

After persistent and often harsh criticism for its handling of the COVID-19 pandemic and now the monkeypox emergency, the Centers for Disease Control and Prevention will undergo a significant overhaul, involving cultural and structural changes aimed at realizing its prior reputation as the world's premier public health agency. From a report: "For 75 years, CDC and public health have been preparing for COVID-19, and in our big moment, our performance did not reliably meet expectations," CDC Director Rochelle Walensky said in an email to CDC's 11,000-person staff Wednesday, which was seen by The New York Times and Stat News. "My goal is a new, public health action-oriented culture at CDC that emphasizes accountability, collaboration, communication, and timeliness."

Though the CDC endured meddling and undermining during the Trump administration, many of the agency's pandemic misfires were unforced errors -- such as the failure to stand up reliable SARS-CoV-2 testing in the early days and muddled messaging on masks. In a meeting with senior staff Wednesday, Walensky made a startling acknowledgement of the failures while outlining the overhaul in broad strokes. The cultural changes appear aimed at stamping out pedantic data analyses that have slowed and hampered the agency's public health responses. A briefing document provided to the Times said the goal is for CDC staff to "produce data for action" as opposed to "data for publication." As such, the agency will cut down on the time allowed to review studies before they're released. The agency will also change the way it grants promotions to staff, placing more emphasis on public health impact rather than the number of scientific publications.

An anonymous reader quotes a report from The Guardian: China has overtaken the US as the world leader in both scientific research output and "high impact" studies, according to a report published by Japan's science and technology ministry. The report, which was published by Japan's National Institute of Science and Technology Policy (NISTP) on Tuesday, found that China now publishes the highest number of scientific research papers yearly, followed by the US and Germany. The figures were based on yearly averages between 2018 and 2020, and drawn from data compiled by the analytics firm Clarivate.

The Japanese NISTP report also found that Chinese research comprised 27.2% of the world's top 1% most frequently cited papers. The number of citations a research paper receives is a commonly used metric in academia. The more times a study is cited in subsequent papers by other researchers, the greater its "citation impact." The US accounted for 24.9% of the top 1% most highly cited research studies, while UK research was third at 5.5%. China published a yearly average of 407,181 scientific papers, pulling ahead of the US's 293,434 journal articles and accounting for 23.4% of the world's research output, the report found. China accounted for a high proportion of research into materials science, chemistry, engineering and mathematics, while US researchers were more prolific in research into clinical medicine, basic life sciences and physics. "China is one of the top countries in the world in terms of both the quantity and quality of scientific papers," Shinichi Kuroki of the Japan Science and Technology Agency told Nikkei Asia. "In order to become the true global leader, it will need to continue producing internationally recognized research."

David Glowacki, an artist and computational molecular physicist, has created a VR experience called Isness-D that aims to recapture a transcendence experience he had when he fell in the mountains fifteen years ago. "[O]n four key indicators used in studies of psychedelics, the program showed the same effect as a medium dose of LSD or psilocybin (the main psychoactive component of 'magic' mushrooms)," reports MIT Technology Review. From the report: Isness-D is designed for groups of four to five people based anywhere in the world. Each participant is represented as a diffuse cloud of smoke with a ball of light right about where a person's heart would be. Participants can partake in an experience called energetic coalescence: they gather in the same spot in the virtual-reality landscape to overlap their diffuse bodies, making it impossible to tell where each person begins and ends. The resulting sense of deep connectedness and ego attenuation mirrors feelings commonly brought about by a psychedelic experience.

[...] To create it, Glowacki took aesthetic inspiration from quantum mechanics -- as he puts it, "where the definition of what's matter and what's energy starts to become blurred." For their paper, Glowacki and his collaborators measured the emotional response Isness-D elicited in 75 participants. They based their measurements on four metrics used in psychedelics research -- the MEQ30 (a mystical experience questionnaire), the ego dissolution inventory scale, the "communitas" scale, and the "inclusion of community in self" scale. Communitas is defined as an experience of intense shared humanity that transcends social structure. Participants' responses were then compared with those given in published, double-blind psychedelics studies. For all four metrics, Isness-D elicited responses indistinguishable from those associated with medium doses of psychedelics. On the mystical experience scale, Isness-D participants reported an experience as intense as that elicited by 20 milligrams of psilocybin or 200 micrograms of LSD, and stronger than that induced by microdoses of either substance. The findings have been published in the journal Nature Scientific Reports.

Steve Nadis, reporting for Quanta Magazine: In 1963, the mathematician Roy Kerr found a solution to Einstein's equations that precisely described the space-time outside what we now call a rotating black hole. (The term wouldn't be coined for a few more years.) In the nearly six decades since his achievement, researchers have tried to show that these so-called Kerr black holes are stable. What that means, explained Jeremie Szeftel, a mathematician at Sorbonne University, "is that if I start with something that looks like a Kerr black hole and give it a little bump" -- by throwing some gravitational waves at it, for instance -- "what you expect, far into the future, is that everything will settle down, and it will once again look exactly like a Kerr solution." The opposite situation -- a mathematical instability -- "would have posed a deep conundrum to theoretical physicists and would have suggested the need to modify, at some fundamental level, Einstein's theory of gravitation," said Thibault Damour, a physicist at the Institute of Advanced Scientific Studies in France.

In a 912-page paper posted online on May 30, Szeftel, Elena Giorgi of Columbia University and Sergiu Klainerman of Princeton University have proved that slowly rotating Kerr black holes are indeed stable. The work is the product of a multiyear effort. The entire proof -- consisting of the new work, an 800-page paper by Klainerman and Szeftel from 2021, plus three background papers that established various mathematical tools -- totals roughly 2,100 pages in all. The new result "does indeed constitute a milestone in the mathematical development of general relativity," said Demetrios Christodoulou, a mathematician at the Swiss Federal Institute of Technology Zurich. Shing-Tung Yau, an emeritus professor at Harvard University who recently moved to Tsinghua University, was similarly laudatory, calling the proof "the first major breakthrough" in this area of general relativity since the early 1990s. "It is a very tough problem," he said. He did stress, however, that the new paper has not yet undergone peer review. But he called the 2021 paper, which has been approved for publication, both "complete and exciting."

An anonymous reader quotes a report from Scientific American, written by Almira Osmanovic Thunstrom: On a rainy afternoon earlier this year, I logged in to my OpenAI account and typed a simple instruction for the company's artificial intelligence algorithm, GPT-3: Write an academic thesis in 500 words about GPT-3 and add scientific references and citations inside the text. As it started to generate text, I stood in awe. Here was novel content written in academic language, with well-grounded references cited in the right places and in relation to the right context. It looked like any other introduction to a fairly good scientific publication. Given the very vague instruction I provided, I didn't have any high expectations: I'm a scientist who studies ways to use artificial intelligence to treat mental health concerns, and this wasn't my first experimentation with AI or GPT-3, a deep-learning algorithm that analyzes a vast stream of information to create text on command. Yet there I was, staring at the screen in amazement. The algorithm was writing an academic paper about itself.

My attempts to complete that paper and submit it to a peer-reviewed journal have opened up a series of ethical and legal questions about publishing, as well as philosophical arguments about nonhuman authorship. Academic publishing may have to accommodate a future of AI-driven manuscripts, and the value of a human researcher's publication records may change if something nonsentient can take credit for some of their work.

Some stories about GPT-3 allow the algorithm to produce multiple responses and then publish only the best, most humanlike excerpts. We decided to give the program prompts -- nudging it to create sections for an introduction, methods, results and discussion, as you would for a scientific paper -- but interfere as little as possible. We were only to use the first (and at most the third) iteration from GPT-3, and we would refrain from editing or cherry-picking the best parts. Then we would see how well it does. [...] In response to my prompts, GPT-3 produced a paper in just two hours. "Currently, GPT-3's paper has been assigned an editor at the academic journal to which we submitted it, and it has now been published at the international French-owned pre-print server HAL," adds Thunstrom. "We are eagerly awaiting what the paper's publication, if it occurs, will mean for academia."

"Perhaps it will lead to nothing. First authorship is still one of the most coveted items in academia, and that is unlikely to perish because of a nonhuman first author. It all comes down to how we will value AI in the future: as a partner or as a tool."

Recent studies in humans and mice have shown that late nights and early mornings may cause long lasting damage to your brain. From a report: The sleep debt collectors are coming. They want you to know that there is no such thing as forgiveness, only a shifting expectation of how and when you're going to pay them back. You think of them as you lie in bed at night. How much will they ask for? Are you solvent? You fall asleep, then wake up in a cold sweat an hour later. You fall asleep, then wake up, drifting in and out of consciousness until morning. As most every human has discovered, a couple nights of bad sleep is often followed by grogginess, difficulty concentrating, irritability, mood swings and sleepiness.

For years, it was thought that these effects, accompanied by cognitive impairments like lousy performances on short-term memory tests, could be primarily attributed to a chemical called adenosine, a neurotransmitter that inhibits electrical impulses in the brain. Spikes of adenosine had been consistently observed in sleep-deprived rats and humans. Adenosine levels can be quickly righted after a few nights of good sleep, however. This gave rise to a scientific consensus that sleep debt could be forgiven with a couple of quality snoozes -- as reflected in casual statements like "I'll catch up on sleep" or "I'll be more awake tomorrow."

But a review article published recently in the journal Trends in Neurosciences contends that the folk concept of sleep as something that can be saved up and paid off is bunk. The review, which canvassed the last couple of decades of research on long term neural effects of sleep deprivation in both animals and humans, points to mounting evidence that getting too little sleep most likely leads to long-lasting brain damage and increased risk of neurodegenerative disorders like Alzheimer's disease. "This is really, really important in setting the stage for what needs to be done in sleep health and sleep science," said Mary Ellen Wells, a sleep scientist at the University of North Carolina, who did not contribute to the review.