Submission + - US, UK Sanction 7 Men Tied To Trickbot Hacking Group (krebsonsecurity.com)

An anonymous reader writes: Authorities in the United States and United Kingdom today levied financial sanctions against seven men accused of operating “Trickbot,” a cybercrime-as-a-service platform based in Russia that has enabled countless ransomware attacks and bank account takeovers since its debut in 2016. The U.S. Department of the Treasury says the Trickbot group is associated with Russian intelligence services, and that this alliance led to the targeting of many U.S. companies and government entities. Initially a stealthy trojan horse program delivered via email and used to steal passwords, Trickbot evolved into “a highly modular malware suite that provides the Trickbot Group with the ability to conduct a variety of illegal cyber activities, including ransomware attacks,” the Treasury Department said.

“During the height of the COVID-19 pandemic in 2020, Trickbot targeted hospitals and healthcare centers, launching a wave of ransomware attacks against hospitals across the United States,” the sanctions notice continued. “In one of these attacks, the Trickbot Group deployed ransomware against three Minnesota medical facilities, disrupting their computer networks and telephones, and causing a diversion of ambulances. Members of the Trickbot Group publicly gloated over the ease of targeting the medical facilities and the speed with which the ransoms were paid to the group.”

Only one of the men sanctioned today is known to have been criminally charged in connection with hacking activity. According to the Treasury Department, the alleged senior leader of the Trickbot group is 34-year-old Russian national Vitaly “Bentley” Kovalev. A New Jersey grand jury indicted Kovalev in 2012 after an investigation by the U.S. Secret Service determined that he ran a massive “money mule” scheme, which used phony job offers to trick people into laundering money stolen from hacked small to mid-sized businesses in the United States. The 2012 indictment against Kovalev relates to cybercrimes he allegedly perpetrated prior to the creation of Trickbot.

Power

Bill Gates Urges High-Voltage, Long-Distance Power Lines for Clean Energy Future (gatesnotes.com) 139

Bill Gates is calling for "high-voltage transmission lines that can carry electricity long distances," calling them the key to a clean-energy future: [M]any of the best places to generate lots of electricity are far away from urban centers... so to maximize clean energy's potential, we're going to need much longer lines to move that power from where it's made to where it's needed.... Beyond being old and outdated, there's another big problem making everything worse: Our grid is fragmented. Most people (including me a lot of the time) talk about the "electric grid" as if it's one single grid covering the whole nation from coast to coast, but it's actually a complicated patchwork of systems with different levels of connection to one another.

Our convoluted network prevents communities from importing energy when challenges like extreme weather shut off their power. It also prevents power from new clean energy projects from making it to people's homes. Right now, over 1,000 gigawatts worth of potential clean energy projects are waiting for approval — about the current size of the entire U.S. grid — and the primary reason for the bottleneck is the lack of transmission. Complicating things further is the fact that new infrastructure projects are typically planned and executed by hundreds of individual utility companies that aren't required to coordinate.

Gates calls for new federal funding and policies , but also faults the permitting processes at the state level as "long, convoluted, and often outdated." As a result, we don't build lines fast enough, and we're slower than other countries. Some states — like New Mexico and Colorado — are doing innovative work to speed up the process. But there is a lot more room for policymakers to work together and make the permit process easier.

Although transmission is primarily a policy problem, innovation will help too. For example, grid-enhancing technologies like dynamic line ratings, power flow controls, and topology optimization could increase the capacity of the existing system. Breakthrough Energy Ventures, which is part of the climate initiative I helped start, has invested in new technologies like advanced conductors and superconductors — wires that use cutting-edge materials to get more energy out of smaller lines. But these technologies aren't a substitute for real systemic improvements and building lines in places where they don't already exist.

"By the 2030s, we need to build so many new lines that they would reach to the moon if they were strung together," Gates says in a video accompanying the article. "And by 2050, we'll need to more than double the size of the grid, while replacing most of the existing wires." But noting today's power grid problems, Gates writes optimistically that "It doesn't have to be this way."

And he ultimately believes that modernized power grids "will lead to lower emissions, cleaner air, more jobs, fewer blackouts, more energy and economic security, and healthier communities across the country."
Linux

Ubisoft's Launcher Broke Its Own Games on Linux and Steam Deck (pcgamer.com) 44

Earlier this week NME reported: With an update to Ubisoft Connect, Ubisoft has broken Steam Deck and Linux compatibility for a number of its biggest games including The Division 2 and Assassin's Creed Valhalla. As reported by GamingOnLinux, the compatibility issues were caused by Ubisoft issuing an update for its Ubisoft Connect launcher. Even if Ubisoft's titles are bought through Steam, they still launch with Ubisoft Connect and require a connection with the third-party launcher to run.
"Thankfully, Steam Deck users have already figured out that updating the device's Proton Experimental version and switching all Ubisoft games to use it resolves the issue," added GameRant.

But Gaming on Linux described the incident as third-party launchers on Steam "once again being a massive nuisance." Why do developers and publishers keep forcing these absolutely useless third-party launchers on us? Never once have I, or anyone I've spoken to, actually wanted them. They only ever cause problems and solve basically nothing that Steam cannot already do directly.
And PC Gamer agrees: This is yet another example of frustrating third-party launchers only making everyone's lives more difficult. I don't even want to know Ubisoft Connect exists, let alone have it flash up in my face and not be able to play my games because it's not working properly. I understand these companies want my data but you're supposed to be sneakier and better at getting it than this by now.
Microsoft

Microsoft Kills Off AltspaceVR Amid Major Layoffs (uploadvr.com) 30

AltspaceVR is shutting down in March as Microsoft decimated its teams working in VR & AR this week as part of a major workforce reduction across the entire company. Upload VR reports: Altspace was one of the early VR-based social networking services alongside others like Rec Room and VRChat. As an independent startup Altspace ran out of money, but in 2017 Microsoft acquired it and continued the effort. Microsoft says it is shifting "our focus to support immersive experiences powered by Microsoft Mesh." We tried out Mesh on HoloLens 2 back in 2021 and were pretty impressed by its functionality, with the company saying it'll be officially launching the service as "a new platform for connection and collaboration, starting by enabling workplaces around the world."

Microsoft posted instructions for creators on how to download content before the March 10, 2023 shutdown date, while noting "AltspaceVR Worlds are not able to be downloaded in full or ported directly to another platform because AltspaceVR is a mix of Worlds made up of a collection of assets owned by a variety of different entities." "While you cannot download them in full, you are able to download items from your Worlds data, which we call meta-data," Microsoft explains, providing people files with references noted as comma-separated values.
Here's an excerpt from Microsoft's "sunset" update on altvr.com: "The decision has not been an easy one as this is a platform many have come to love, providing a place for people to explore their identities, express themselves, and find community. It has been a privilege to help unlock passions among users, from educational opportunities for personal growth to the development of unique and wonderful events, groundbreaking art, and immersive experiences -- enabling this community to achieve more. With Mesh, we aspire to build a platform that offers the widest opportunity to all involved, including creators, partners and customers."
Technology

Rackspace Founder Says It's 'On Trajectory of Death' (expressnews.com) 75

Richard Yoo, who founded and helped build the website hosting company that became San Antonio's premier technology firm, believes he's watching its collapse. From a report: The reputation of the company now known as Rackspace Technology, he said, "is eroding rapidly" after years of shifting business plans, executive shuffles, financial losses, staff cuts and, finally, the Dec. 2 ransomware attack that left tens of thousands of customers without access to their email, contact and calendar data.

"This is the beginning of the end," Yoo said last week. "It's already just a midsize business in San Antonio. This is not a company that's on a trajectory of growth. They're on a trajectory of death. It will not be around." He puts the blame for Rackspace's deepening financial struggles -- it's posted a steady string of quarterly losses, and the value of its stock has fallen 80 percent in the past year -- on its replacement of tech-oriented leadership with board members and managers "who don't have any connection with the product." He said there's "no culture" at the company after it laid off hundreds of local staffers while it expanded globally. And he scoffed at the idea of being a "Racker," saying he never adopted the term the company uses for its employees and identity.

United Kingdom

England Makes Gigabit Internet a Legal Requirement For New Homes (theverge.com) 50

An anonymous reader quotes a report from The Verge: Amendments to Building Regulations 2010 were announced by the Department for Digital, Culture, Media, and Sport (DCMS) on January 6th that mandate new homes constructed in England to be fitted with infrastructure and connections required to achieve gigabit internet connectivity. Connection costs will be capped at £2,000 per home, and developers must still install gigabit-ready infrastructure (including ducts, chambers, and termination points) and the fastest-available connection if they're unable to secure a gigabit connection within the cost cap. The UK government estimates that 98 percent of installations will fall comfortably under that cap, so it's likely been put in place to avoid spiraling chargings in remote, rural areas that need widescale line upgrades. Properties constructed in Scotland, Wales, and Northern Ireland may be exempt from this new legislation as each country sets its own building regulations independently from England.

The new legislation was introduced on December 26th, 2022, following a 12-month technical consultation that indicated around 12 percent of 171,190 new homes constructed in England didn't have gigabit broadband access upon completion. DCMS claims that gigabit broadband is currently available in over 72 percent of UK households and is targeting full nationwide gigabit-capable broadband coverage across the UK by 2030. In order to meet that goal, another law has also been introduced to make it easier to install faster internet connections into existing flats and apartments. Previously, millions of tenants living in the UK's estimated 480,000 multi-dwelling units (MDUs) needed to obtain permission from the landowner to allow a broadband operator to install connection upgrades. Broadband companies estimate that around 40 percent of these requests are ignored by landlords, leaving tenants unable to upgrade their services even if they're unfit for use. Now, the Telecommunications Infrastructure (Leasehold Property) Act 2021 (TILPA) allows broadband providers in England and Wales to seek access rights via court if landlords and land owners don't respond to installation requests within 35 days.
"An additional 2,100 residential buildings a year are estimated to be connected to faster broadband speeds as a result of these new rules, and similar legislation is due to come into force in Scotland later this year," adds the report. "The existing appeals process that allows landlords to refuse access requests will not be affected."

Submission + - England Makes Gigabit Internet a Legal Requirement For New Homes (theverge.com)

An anonymous reader writes: Amendments to Building Regulations 2010 were announced by the Department for Digital, Culture, Media, and Sport (DCMS) on January 6th that mandate new homes constructed in England to be fitted with infrastructure and connections required to achieve gigabit internet connectivity. Connection costs will be capped at £2,000 per home, and developers must still install gigabit-ready infrastructure (including ducts, chambers, and termination points) and the fastest-available connection if they’re unable to secure a gigabit connection within the cost cap. The UK government estimates that 98 percent of installations will fall comfortably under that cap, so it’s likely been put in place to avoid spiraling chargings in remote, rural areas that need widescale line upgrades. Properties constructed in Scotland, Wales, and Northern Ireland may be exempt from this new legislation as each country sets its own building regulations independently from England.

The new legislation was introduced on December 26th, 2022, following a 12-month technical consultation that indicated around 12 percent of 171,190 new homes constructed in England didn’t have gigabit broadband access upon completion. DCMS claims that gigabit broadband is currently available in over 72 percent of UK households and is targeting full nationwide gigabit-capable broadband coverage across the UK by 2030. In order to meet that goal, another law has also been introduced to make it easier to install faster internet connections into existing flats and apartments. Previously, millions of tenants living in the UK’s estimated 480,000 multi-dwelling units (MDUs) needed to obtain permission from the landowner to allow a broadband operator to install connection upgrades. Broadband companies estimate that around 40 percent of these requests are ignored by landlords, leaving tenants unable to upgrade their services even if they’re unfit for use. Now, the Telecommunications Infrastructure (Leasehold Property) Act 2021 (TILPA) allows broadband providers in England and Wales to seek access rights via court if landlords and land owners don’t respond to installation requests within 35 days.

Television

Samsung Bets On MicroLED and 8K For Its Premium 2023 TVs (engadget.com) 42

Four years after introducing its MicroLED technology at CES 2018, Samsung claims the technology is ready for the masses and "will set the standard for picture quality in 2023," reports Engadget. From the report: At CES 2023, the company announced it would offer 50-, 63-, 76-, 89-, 101-, 114- and 140-inch MicroLED models, greatly expanding the amount of choice consumers have when it comes to the new display technology. Samsung didn't provide pricing and availability information for the expanded line, but the company claims the new models are its most affordable MicroLED TVs to date. [...] The set sports a 240Hz variable refresh rate and 2-nanosecond response time. It also offers 20-bit black detail for "intense" contrast.

Samsung is also promising upgrades for its Neo QLED sets, starting with the line's new flagship. The QN900C features an 8K Quantum MiniLED-lit panel capable of maxing out at 4,000 nits of brightness. As with Samsung's 2022 Neo QLED sets, the QN900C features a 14-bit backlight. However, the TV offers even better contrast thanks to a tweak the company made to its 8K Real Depth Enhancer Pro software. Samsung is also promising improved picture quality when viewing older movies and TV shows thanks to the inclusion of its new Auto HDR Remastering algorithm, which can automatically apply HDR effects to standard dynamic range content.

For those who would prefer a 4K set, there's also the QN935C. Samsung's new 4K flagship features a redesigned power board that eliminates the need for an external connection box and allows for bezels that are less than 20mm thick. The QN935C also features top-firing speakers, allowing the set to produce Dolby Atmos sound without a dedicated soundbar. You can use both the QN900C and QN935C as a smart home hub thanks to the fact Samsung's entire 2023 Neo QLED line will feature built-in Zigbee and Matter Thread all-in-one modules.
As for its OLED models, Samsung announced the 2023 QD-OLED TV line, which will offer up to 2,000 nits of peak brightness and support 144Hz refresh rates -- all while being more energy efficient than before. "Additionally, the company has gone out of its way to get the panels AMD FreeSync Premium Pro certified," adds Engadget.
Privacy

WhatsApp Launches Proxy Support To Help Users Circumvent Internet Blocks (techcrunch.com) 5

WhatsApp is launching proxy support for its users all over the world, the company announced on Thursday. The support will allow users to maintain access to WhatsApp if their connection is blocked or disrupted. From a report: Choosing a proxy enables users to connect to WhatsApp through servers set up by volunteers and organizations around the world dedicated to helping people communicate freely. WhatsApp says connecting via proxy maintains the same level of privacy and security the app provides, and that personal messages will still be protected by end-to-end encryption. The company says messages will not be visible to anyone in between, not the proxy servers, WhatsApp or Meta.

"Our wish for 2023 is that these internet shutdowns never occur," WhatsApp wrote in a blog post. "Disruptions like we've seen in Iran for months on end deny people's human rights and cut people off from receiving urgent help. Though in case these shutdowns continue, we hope this solution helps people wherever there is a need for secure and reliable communication."

Games

EA Says It Can't Recover 60% of Players' Corrupted Madden Franchise Save Files 63

An anonymous reader shares a report: EA says that a temporary "data storage issue" led to the corruption of many Madden NFL 23 players' Connected Franchise Mode (CFM) save files last week. What's worse, the company now estimates it can recover fewer than half of those corrupted files from a backup. The issue started last Monday, December 26, when EA tweeted that it was "aware of players experiencing connection issues when trying to connect to CFM." That problem lasted until Wednesday, December 28, when EA announced that subsequent server maintenance meant that "users should now be able to play CFM without issue."

But users who attempted to log in to play online franchise games during a 22-hour period ranging from Wednesday afternoon to Thursday morning saw their franchise save data corrupted by the aforementioned "data storage issue," as EA confirmed over the weekend. And while EA says some of those corrupted save files can be recovered from a backup, it adds that the development team is "currently projecting around 40% of leagues to be recovered." Players that didn't log in during the outage period last week should be unaffected, EA says, adding that CFM is now "up and running" and is "safe to log in and play." But the company offered a similar message on Wednesday afternoon, just before the period that led players who logged in to lose their save files in the first place.

Submission + - Two Washington men charged in 4 substation attacks on Christmas that cut power (foxnews.com)

schwit1 writes: Two men were charged Tuesday in connection to all four substation attacks that occurred in western Washington state over Christmas, as the federal government pursues prosecution for increased instances of electric grid sabotage across the country this winter.

Matthew Greenwood, 32, and Jeremy Crahan, 40, both of Puyallup, Washington, have been charged with conspiracy to damage energy facilities and possession of an unregistered firearm.

Security

FBI Investigating 3Commas Data Breach (coindesk.com) 25

The FBI is investigating the 3Commas data breach, CoinDesk is reporting. From the report: The investigation comes after weeks of criticism from users of the Estonia-based crypto trading service, who say its CEO repeatedly brushed off warning signs that the platform had leaked user data. This week, 100,000 Binance and KuCoin API keys linked to 3Commas were leaked by an anonymous person. On Thursday, two 3Commas users told CoinDesk that they were contacted by agents from the FBI's Cincinnati Field Office in connection to the leak.

Over the last several months, dozens of 3Commas users found that the service had, without their consent, traded away funds on crypto exchanges they'd linked to it. Initially, 3Commas said that these users were most likely phished and insisted that the platform was safe. The API database leaker insinuated that the 3Commas keys had been sold by someone from within the company, but 3Commas CEO Yuriy Sorokin said in a statement on Thursday that "3Commas stresses that it has found no evidence during the internal investigation that any employee of 3Commas was somehow involved in attacks against the API data."

The Almighty Buck

Solana Founders Scramble To Move Past FTX's Stain on Their Token (bloomberg.com) 36

Solana, the blockchain network once championed by Sam Bankman-Fried, is drawing intense scrutiny as industry watchers wonder whether its former close ties to the disgraced crypto mogul and his now-defunct FTX empire will jeopardize its future. From a report: Its founders are doing everything they can to break that connection. The price of Solana's crypto token, SOL, has plummeted 96% from its all-time high of $260 in November 2021 to about $10, hurt first by a year-long crypto rout that engulfed the whole market and then again by FTX's fall. SOL dropped as much as 12% on Wednesday alone on concern large holders are offloading the token, which is used as the base cryptocurrency for financial transactions on the blockchain.

Anatoly Yakovenko, co-founder of Solana Labs, the startup that developed the blockchain, said in an interview earlier this month that he doesn't usually comment on price, and that the focus instead should be on "the technology and having people build something awesome that's decentralized." But the collapse of FTX is having an impact -- both personal and professional -- on Solana and its founders. And the token's drop can be seen as an expression of waning confidence in the whole platform, which at its peak sported a market value of almost $80 billion and is now a tiny fraction of that.

Yakovenko said roughly 4% of teams building projects on Solana now were acutely affected by FTX's collapse. Some platforms had funds custodied on the crypto exchange. About 80% of teams on Solana's blockchain had no exposure at all to FTX, Yakovenko said, referring to survey data, adding that he was connecting severely impacted founders with investors who could potentially provide emergency capital. "There's definitely more to Solana than FTX," Yakovenko said. Still, the network's longstanding ties to FTX and Alameda Research, the crypto trading firm co-founded by Bankman-Fried, may make it hard for some to move past the association. The two firms helped support Solana by purchasing SOL tokens in bulk from the Solana Foundation, the nonprofit that helps support the blockchain. Alameda also bought large quantities of SOL from Solana Labs. [...] Alameda and FTX's venture arm also invested in multiple projects that operated on Solana, while FTX built its own projects on the network, including the decentralized finance platform Serum. These types of efforts, from an industry leader with substantial influence in the market, helped introduce Solana to many crypto users, Gokal said.

Robotics

3D-Printed Self-Balancing Robot Brings Control Theory To Life (hackaday.com) 10

An anonymous reader quotes a report from Hackaday: Stabilizing an inverted pendulum is a classic problem in control theory, and if you've ever taken a control systems class you might remember seeing pages full of differential equations and bode diagrams just to describe its basic operation. Although this might make such a system seem terribly complicated, actually implementing all of that theory doesn't have to be difficult at all, as [Limenitis Reducta] demonstrates in his latest project. All you need is a 3D printer, some basic electronic skills and knowledge of Python. The components needed are a body, two wheels, motors to drive those wheels and some electronics. [Limenitis] demonstrates the design process in the video [here] (in Turkish, with English subtitles available) in which he draws the entire system in Fusion 360 and then proceeds to manufacture it. The body and wheels are 3D-printed, with rubber bands providing some traction to the wheels which would otherwise have difficulty on slippery surfaces.

Two stepper motors drive the wheels, controlled by a DRV8825 motor driver, while an MPU-9250 accelerometer and gyroscope unit measures the angle and acceleration of the system. The loop is closed by a Raspberry Pi Pico that implements a PID controller: another control theory classic, in which the proportional, integral and derivative parameters are tuned to adapt the control loop to the physical system in question. External inputs can be provided through a Bluetooth connection, which makes it possible to control the robot from a PC or smartphone and guide it around your living room.
All design files and software are available on Limenitis' GitHub page.
Bitcoin

How Scammers Took a Winnipeg Town For $430K Using Bitcoin (www.cbc.ca) 37

Slashdot reader lowvisioncomputing shares a story from the CBC about an elaborate heist discovered "when the chief administrative officer of a southwestern Manitoba rural municipality [population: 3,300] noticed the series of unusual cash withdrawals from its bank account...." It began with a job advertisement. A seemingly legitimate company, with a professional website and a Nova Scotia address, claimed it was looking for cash processors. The contract was for one month. Employees could work from home.

They were told they would receive payments to their credit cards, which they would be expected to move to their bank accounts. They would then withdraw the payments, convert them into bitcoin, and send that to another account.... The majority of the 18 people hired were young and lived in various communities across the country.... Anyone who did an internet search for the company would find a professional website, with information matching what was provided in the employment agreement.

In early December 2019, the cybercriminals sent a phishing email to multiple people at the municipal office of WestLake-Gladsone, a municipality about 150 kilometres west of Winnipeg, on the southwestern shore of Lake Manitoba. At least one person clicked on the link, which allowed the hackers to get into the municipality's computers and bank accounts. But weeks went by and nothing happened, so the municipality didn't report it to the police. It was only after the money disappeared that the municipality discovered the two incidents were connected, said Kate Halashewski, who at the time was the assistant chief administrative officer for the Municipality of WestLake-Gladstone....

Court documents say that on Dec. 19, 2019, a person logged into the municipality's bank account and changed the password, along with the personal verification questions. Over the next 17 days, the cyberattackers added the 18 "employees" hired as payees and began systematically making withdrawals, transferring the money to the employees' credit cards. Dozens of withdrawals were made, totalling $472,377, according to court documents — a considerable amount for a municipality with an entire annual budget of $7 million.

Those withdrawals weren't discovered until Jan. 6, when Halashewski saw 48 bank transfers — each less than $10,000 — going to unfamiliar accounts.... Once they'd completed the initial transfers and conversion, the bitcoin was then sent to the private account of the scammers — who cybersecurity experts say likely aren't in Canada....

The municipality finally announced it had lost nearly half a million dollars in an Oct. 12, 2020, news release.... No arrests have been made in connection with the WestLake-Gladstone cyberattack and RCMP say it is no longer under active investigation.

Robotics

Meet Two Startups Bringing Robots to Restaurants (seattletimes.com) 75

It's a coffee shop and and robotics startup. Founded in 2020, Seattle-based Artly has seven locations in Washington, Oregon and California, reports the Seattle Times, noting that each location has a mechanically dexterous robotic arm that they're calling a "barista bot" that "makes the espresso, pours the milk, steams the foam and puts it all together, topping it off with a carefully drawn foam leaf." [P]ressing market needs were behind the innovation. Cost concerns and high employee turnover in food services have led Artly and others to provide automated solutions to restaurants and businesses, even before the pandemic hit and brought additional challenges. Just a couple of years into operation, Artly CEO Meng Wang said the company has maintained healthy operating margins — the profit a company makes after paying for costs of production — by eliminating the biggest expense in food business: labor. For a coffee shop that would need two or three baristas, Artly needs one staffer, in addition to a barista bot like Jarvis. Artly reinvests the money it saves from labor into sourcing more quality coffee, Wang said.

Artly isn't alone in introducing robot help in food preparation. Another Seattle-based startup, Picnic, offers automation solutions for a staple of the American diet: pizza. Its food prep station can produce up to 100 pizzas in one hour using metered toppings. Since Picnic was founded in 2016, its robots have assembled pizzas in many places, including Seattle's T-Mobile Park and the Las Vegas Convention Center. The company has seen a growing interest in its robots. This summer, Picnic announced partnerships with pizzeria Moto's West Seattle location and a Domino's store in Berlin.... With a robotics-as-a-service business model, the standard full offering for operators is $4,500 a month on a 36-month contract.

But the founder also told the newspaper how their customers reacted to their barista bots: [C]ustomers were initially intrigued and excited about the robot barista, but the service was slower than with a human barista. He said customers craved the connection with the person making their coffee. "When [customers] go to the coffee shop, their expectation is to be served by a human," Yang said.

With that, Artly has focused on opening locations in shopping malls and business office buildings rather than standard coffee shops.

Medicine

What Causes Alzheimer's? Scientists Are Rethinking the Answer (quantamagazine.org) 41

"After decades in the shadow of the reigning model for Alzheimer's disease, alternative explanations are finally getting the attention they deserve," writes Quanta magazine — in a 10,000-word update on where we are now: Three decades ago, scientists thought they had cracked the medical mystery of what causes Alzheimer's disease with an idea known as the amyloid cascade hypothesis. It accused a protein called amyloid-beta of forming sticky, toxic plaques between neurons, killing them and triggering a series of events that made the brain waste away.... Decades of work and billions of dollars went into funding clinical trials of dozens of drug compounds that targeted amyloid plaques. Yet almost none of the trials showed meaningful benefits to patients with the disease....

A stream of recent findings has made it clear that other mechanisms may be at least as important as the amyloid cascade as causes of Alzheimer's disease.... The emerging new models of the disease are more complex than the amyloid explanation, and because they are still taking shape, it's not clear yet how some of them may eventually translate into therapies. But because they focus on fundamental mechanisms affecting the health of cells, what's being learned about them might someday pay off in new treatments for a wide variety of medical problems, possibly including some key effects of aging.... While these alternate ideas were once hushed and thrown under the rug, now the field has broadened its attention.

The article explores the theory — derived from research on genetically-engineered mice — that neurons bulging with toxic accumulations of proteins and molecules could be mistaken for classic amyloid plaques outside cells. (But in fact "the extracellular amyloid plaques weren't killing the cells — because the cells were already dead.") Scientists are now also investigating lysosomes, cholesterol metabolism, and even the immune system.

To say that the amyloid hypothesis is dead would be overstating it, said Donald Weaver, a co-director of the Krembil Brain Institute in Toronto, but "I would say that the amyloid hypothesis is insufficient...."

By 2017, 146 drug candidates for treating Alzheimer's disease had been deemed unsuccessful. Only four drugs had been approved, and they treated the symptoms of the disease, not its underlying pathology. The results were so disappointing that in 2018, Pfizer pulled out of Alzheimer's research. A 2021 review that compared the results of 14 of the major trials confirmed that reducing extracellular amyloid did not greatly improve cognition....

The hypothesis took another hit last July when a bombshell article in Science revealed that data in the influential 2006 Nature paper linking amyloid plaques to cognitive symptoms of Alzheimer's disease may have been fabricated. The connection claimed by the paper had convinced many researchers to keep pursuing amyloid theories at the time.

Communications

NASA'S ICON Space Weather Satellite Has Suddenly Gone Silent (gizmodo.com) 29

A three-year-old NASA satellite lost touch with ground controllers two weeks ago and is now wandering through low Earth orbit without supervision. Sadly, the space agency fears the worst. Gizmodo reports: NASA's Ionospheric Connection Explorer (ICON) mission has not communicated with ground stations since November 25 due to some sort of glitch the space agency is yet to identify, NASA wrote in a blog post on Wednesday. The spacecraft is equipped with an onboard command loss timer that's designed to reset ICON in the event that contact is lost for eight days, but the reset seemingly did not work as the team was still unable to communicate with the spacecraft on December 5 after the power cycle was complete.

Although silent, the ICON spacecraft is still intact. NASA used the Department of Defense's Space Surveillance Network to confirm that ICON is still out there in one piece, according to the space agency. But communication is obviously key for orbiting spacecraft, as it allows the mission team to send commands to satellites and also receive data through downlinked signals. "The ICON mission team is working to troubleshoot the issue and has narrowed the cause of the communication loss to problems within the avionics or radio-frequency communications subsystems," NASA wrote in the blog post. "The team is currently unable to determine the health of the spacecraft, and the lack of a downlink signal could be indicative of a system failure." Oof, that doesn't sound good.

Intel

Intel's Take on the Next Wave of Moore's Law (ieee.org) 22

The next wave of Moore's Law will rely on a developing concept called system technology co-optimization, Ann B. Kelleher, general manager of technology development at Intel told IEEE Spectrum in an interview ahead of her plenary talk at the 2022 IEEE Electron Device Meeting. From a report: "Moore's Law is about increasing the integration of functions," says Kelleher. "As we look forward into the next 10 to 20 years, there's a pipeline full of innovation" that will continue the cadence of improved products every two years. That path includes the usual continued improvements in semiconductor processes and design, but system technology co-optimization (STCO) will make the biggest difference. Kelleher calls it an "outside-in" manner of development. It starts with the workload a product needs to support and its software, then works down to system architecture, then what type of silicon must be within a package, and finally down to the semiconductor manufacturing process. "With system technology co-optimization, it means all the pieces are optimized together so that you're getting your best answer for the end product," she says.

STCO is an option now in large part because advanced packaging, such as 3D integration, is allowing the high-bandwidth connection of chiplets -- small, functional chips -- inside a single package. This means that what would once be functions on a single chip can be disaggregated onto dedicated chiplets, which can each then be made using the most optimal semiconductor process technology. For example, Kelleher points out in her plenary that high-performance computing demands a large amount of cache memory per processor core, but chipmaker's ability to shrink SRAM is not proceeding at the same pace as the scaling down of logic. So it makes sense to build SRAM caches and compute cores as separate chiplets using different process technology and then stitch them together using 3D integration. A key example of STCO in action, says Kelleher, is the Ponte Vecchio processor at the heart of the Aurora supercomputer. It's composed of 47 active chiplets (as well as 8 blanks for thermal conduction). These are stitched together using both advanced horizontal connections (2.5 packaging tech) and 3D stacking. "It brings together silicon from different fabs and enables them to come together so that the system is able to perform against the workload that it's designed for," she says.

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