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Comment: Re:What is old is new again! (Score 1) 30 30

You need to rethink your views on combinatorial chemistry (CC). Anybody who has run the same reaction over and over again to make analogs found the concept of CC attractive. In fact, there was a substantial amount of good work done to make it possible to do good science using combinatorial chemistry or parallel synthesis or DOS as Schreiber tried to call it. Very little of that work made it to the literature or the market. And very little of it was in place until the late nineties or the aughts. The problem came from the super hype put out by the early advocates and the embrace of CC by management as a way to replace rather than enhance other research approaches. I suspect that we would all be successfully using CC except that management found an even cheaper replacement, outsourced chemists.

Comment: What is old is new again! (Score 2) 30 30

Back in the 70's and 80's, all the pharmaceutical companies had large groups of scientist that spent all their time growing bacteria and stressing them in a huge variety of ways. They collected bacteria from all over the world and grew them up and hit them with all kinds of stress (radiation, chemicals, other bugs, etc) to get them to make interesting and useful secondary metabolites. That's how a lot of drugs, especially antibiotics, were discovered. And if there was some problem with the drugs, the chemists made similar drugs or modifications to those drugs to make them better (like Lipitor). In the 90's there was a fad in the industry to fire all those scientists and replace them with I don't know what. Savings, I think. By the middle of the aughts, they were all gone. I watched it all happen with horror. So if I read the article right, these guys are doing something new and exciting that used to be done routinely 30 years ago. Of course, they're bringing more modern technology to bear on the operation and it's good to see it happening. I just thought the whole process sounded familiar.

+ - Slashdot goes to shit

methano writes: Long time reader Methano is sick and tired of the stupid pop under ads screaming at him and the endless CPU churning flash ads that have come to characterize the experience of being a loyal Slashdot follower. He's seriously thinking of saying goodbye to a once enjoyable but now more often annoying web site.

Comment: Who is Hugh? (Score 1) 307 307

I don't know who this Hugh Pickens guy is but I bet he's mostly a writer. So I guess he has to write something. So he wrote some stuff which is sorta correct, maybe, and sorta just using "ink" to fill space. It has all the expected characteristics of something placed on a line between two points. For some things it's too x and some things it's not x enough and for some things, it's just right, etc. Yawn.

And how does he know what Steve Jobs was expecting?

Comment: Huh? (Score 4, Funny) 190 190

I thought the only time one would consider a ChromeBook is when you expect to have easy internet access at all time and not some crappy 3G connection.

My dad is thinking of getting a car but he lives in the ocean. Is there some way for him to get to the grocery store? I have an Arduino and and a Raspberry pi.


Comment: Re:Knuth vs. whom? Thomas Haigh? OK. (Score 1) 149 149

Give the poor guy a break. He's got a PhD in the sociology of computer science. He's got to do something with that degree. This seems about as useful as anything you can do with a PhD in the sociology of computer science. What else is he gonna do?

There's a whole WORLD in a mud puddle! -- Doug Clifford