I'm mildly autistic, with an official diagnosis. This is considered a disability under the ADA, and thus employers must provide reasonable accommodation.
My employer recently started requiring everyone within 50 miles of an office to come in 2x/week, but the offices are all high-density shared workspaces - a nightmare for anyone on the spectrum. I talked to my manager, he talked to HR, and surprise, surprise, the most logical accommodation was to continue to work from home full time.
If there's one thing HR is terrified of, it's exposing themselves to lawsuits stemming from discrimination or disabilities, so use that to your advantage!