So instead of having the tattoo ink spread out in a relatively benign part of my dermis, instead I'll concentrate it in my lymph nodes. It feels like this could cause problems. How does the body clear the ink from the lymph nodes? Is it broken down; or does it just stay there, possibly clogging the nodes, or acting as an irritant and maybe causing a long-term cancer risk.
Maybe we could also turn the research around. If there were ways to make less digestable or less "attractive" inks, or to pre-train the macrophages to ignore the ink particles, you could make longer-lasting tattoos that need less ink to apply and fewer touchups.