I'm there now.
And as a bonus, my daughter is growing up with me quite near and accessible, and is surprisingly good company when working. (she's 3 now, and I've been home for 2 of those years)
Every now and again I miss the social - but I could just start getting out to social gatherings again to handle that.
And yeah, my coworkers are everywhere on the planet. It's pretty awesome sharing weather stories, for instance. The only real downside though is sometimes I'll forget to stop working and work into timezones on the other side of the planet.
I probably put in more hours now than when I commuted, and have a higher quality of work output.
but my home life is happier, my social life's pretty ok and I'm all in all a lot happier.
So yeah, I'm there. No regrets.