Comment: Re:Designer Humans? (Score 4, Insightful) 149
With the introduction of next-generation sequencing, the costs have actually dropped much faster than you'd predict if it followed Moore's Law. If it's possible to keep that pace up, then we can expect a $1000 genome in 2014-2015, and a $100 dollar genome two or three years later. My guess is that within 10-20 years we could see the widespread use of genetic screening of embryos for genetic diseases. Right now, this all seems very sci-fi. Like something out of Brave New World, Gattaca, or the Eugenics Wars in Star Trek. But unlike a lot of sci-fi, this stuff isn't fictional because it's technologically difficult/impossible, like a faster than light drive, or a flying car. It's sci-fi because it's too expensive to do right now, but that's going to change rapidly within our lifetimes. The development of tests for Down's Syndrome has already led to a dramatic reduction in the number of children born with the condition, it only follows that the development of new tests will have similar effects with other disorders.
This raises a lot of very thorny questions. Say a fetus tests positive for a mutation that is strongly associated with early-onset Alzheimer's disease. What's the moral choice? Is it moral to abort the fetus and spare them and their loved ones the suffering of Alzheimer's? Or would having that life be better than never being born at all? Or would you be willing to take the bet that in the next 30 to 60 years, they develop the therapies to cure or prevent the disease?
It gets more complicated. What if the fetus tested positive for a gene associated with schizophrenia? It might seem cruel to bring someone into the world knowing that's what they had to face. But this is where the story of genetic determinism put forward by modern medicine breaks down. Schizophrenia has a genetic component, true. What's remarkable is that among identical twins (100% shared DNA) the disease is found in both twins less than 50% of the time. Clearly, there's a very strong environmental component (another striking thing that backs this up is that schizophrenia rates are significantly higher in developed countries than in developing countries). Getting these genes makes you vulnerable, true, but there's a better-than-even chance you won't develop the disease at all. Is a less than 50% chance of developing schizophrenia enough to abort a fetus over?
The issues raised by gene sequencing have been pretty hypothetical up until now. It was too expensive and difficult to look at what genetic cards you'd been dealt. But that's going to change.
Comment: Re:Mobile will destroy Google? (Score 1) 214
NPR's Planet Money podcast had a show about the Facebook IPO (http://www.npr.org/blogs/money/2012/05/22/153300390/facebook-now-what).
It's worth a listen, but to sum up, the assessment was that Facebook has a 100:1 price/earnings ratio (valued at 100 billion on 1 billion in profit) which is astronomical (by comparison, Apple's stock price has soared in the past year and is still worth just 13 times earnings). To justify that kind of value, over the next few years Facebook's profits would have to double, and then double again, and then maybe double again. But one of their commentators said that to sustain that kind of growth, Facebook would have to pull in 10% of all advertising dollars on earth.
Meanwhile, their growth seems to have slowed, and businesses just aren't seeing Facebook make a difference. The podcast followed a small pizza shop trying to stir up business with Facebook and found little evidence that it made a difference in their business, and GM recently yanked their Facebook ads because they didn't feel they were effective.
The Wall Street Journal's take on the IPO was to the point: "Facebook shows there's a sucker born every minute" (http://online.wsj.com/article/SB10001424052702304065704577422643666002940.html).
Facebook is actually a profitable business, but selling it at the price they did is just Wall Street and Zuckerberg trying to fuck over investors.
Comment: Investigation or not? (Score 1) 137
"The television station also reported the company isn't incorporated in Rhode Island, but rather Delaware as a limited liability company, which would deem 38 Studios ineligible for tax credits in the state."
This is fraud if anyone but a famous, rich athlete does it.
Comment: They're public airways. End of story. (Score 1) 82
Comment: Pulsar Y911 (Score 1) 465
Comment: Re:I understand, but... (Score 1, Flamebait) 716
don't we have much bigger things to worry about? This isn't a common case....well, it might be if things continue the way they are going.
Yeah, the "Ex-PATRIOT Act" sounds like just a bunch of bullshit political theater. In the case of Saverin, the U.S. will lose an estimated $67 million dollars in tax revenue. Now consider that this $67 million wouldn't even pay for a single F-35 fighter ($195 million), or 6 hours of fighting in Afghanistan ($300 million per day). It's a drop in the bucket compared to the overall defense budget ($700 billion) or entitlement programs like Social Security, Medicare, and Medicaid ($1.5 trillion).
Schumer is just posturing, this bill won't do a damn thing to address the real issues- a poor economy, excessive government spending, and low tax rates- it just seems to be an attempt to distract from the deep problems we face by stirring up popular resentment against one filthy-rich individual.
Here's the situation. Most economists agree that it's not going to be possible to get the deficit under control by either just increasing taxes, or just cutting spending- we're going to have to do both. The question is whether it's going to be possible to raise enough money by just going after the 1%. The 1% do make a ton of money, but there's just not that many of them- only 1% of the population, after all- so even if you taxed them all at 100% it wouldn't balance the budget. That means tax increases on the middle class, who are responsible for the bulk of U.S. federal tax dollars.
Comment: Re:And soon we shall have the immortal (Score 4, Funny) 182
But they will be divided by a contest for power, for whoever takes the head of another shall gain his might.
But where will they find swords small enough to fit into their tiny little mouse paws?
Comment: Re:A matter of share: 85%, 12%, and 2.5% (Score 1) 403
Actually, Firefox usage is more than 92% Windows, and less than 6% Mac.
Comment: Re:Useless anyway (Score 1) 403
The thing that sets the Mozilla Web Apps ecosystem apart from others is that you can run your own marketplace. There can be dozens of competing marketplaces, each with different incentives, economics, target audiences, etc. Mozilla is building a Marketplace but the specs and the formats for receipts and the like are all open source and freely re-implementable.
Set up your own Markeplace and prove the centralized stores wrong.