Follow Slashdot stories on Twitter

 



Forgot your password?
typodupeerror
×

Comment Re:Nano-fabrication (Score 1) 97

Doubt it. But since the pieces of DNA used here are like stiff little rods with unique registry it's a bit closer to the wetware computation featured in Stephenson's The Diamond Age. Also because the DNA only does exactly what the designers tell it to do, it's a bit closer to the live-narrated children's storybook featured in Stephenson's The Diamond Age. Then again, such self-assembly might be useful in manufacturing those kick-ass skateboard wheels featured in Stephenson's The Diamond Age. Damn it, someday something in that book is going to come true.

Comment Groundbreaking (Score 1) 360

Fantastic work. These retrocyclins apparently operate like the currently-used T20 peptides that bind to a particular part of the HIV-1 surface spike protein complex and prevent it from "snapping together" to pull the virus and cell together. It basically interrupts the machinery of cell entry by the HIV particle. The fact that a bit of coaxing is enough to get human cells to produce retrocyclins that act this way is huge. It is plausible that our common ancestor evolved retrocyclins to combat ancient retroviruses and that, when our lineages diverged, our cell surface receptors changed enough to prevent infection by the ancient virus. Having no pressure the retrocyclin genes in the human lineage were allowed to go fallow. Fast forward a few million years and now retroviruses have evolved the means to recognize our cells once again. So it might be that there are a few individuals out there with a mutation at this retrocyclin gene that turns it back on; if HIV remains or becomes more virulent, the human population will become enriched in this mutation. It is remarkable that we can actually shortcut this process to intelligently guide our evolution.

Comment Re:How can he not understand ad support? (Score 1) 881

Ad revenues are also down because advertisers want to spend less, and they to some extent want to spend more wisely on targeted advertising. Murdoch and profile and package his subscriber base so potential advertisers can better target them, plus he could offset ad fees using subscription revenue. Free outlets (his competition) can do neither of these. It's a question of whether he can make himself attractive to advertisers who don't want to shell out the money to advertise on CNN.com or nytimes.com. If he can argue he'll round up more hits per ad dollar spent than will his competitors, he's got a chance.
Security

Submission + - Hackers Get Free Parking in San Francisco

Hugh Pickens writes: "PC World reports that at the Black Hat security conference this week, security researchers say that it is pretty easy for a technically savvy hacker to make a fake payment card that gives them unlimited free parking on San Francisco's smart parking meter system. "It wasn't technically complicated and the fact that I can do it in three days means that other people are probably already doing it and probably taking advantage of it," says Joe Grand. "It seems like the system wasn't analyzed at all." To figure out how the payment system worked, Grand hooked up an oscilloscope to a parking meter and monitored what happened when he used a genuine payment card. Grand discovered the cards aren't digitally signed, and the only authentication between the meter and card is a password sent from the former to the latter. The card doesn't have to know the password, it just has to respond that the password is correct. Examining the meters themselves could yield additional vulnerabilities that might allow someone to conduct other kinds of attacks, such as propagating a virus from meter to meter via the smart cards or a meter minder's PDA. San Francisco launched the $35-million meter project in 2003 to deploy 23,000 smart meters made by Canadian firm J.J. MacKay around the city in an effort to thwart thieves. "If I found this problem, chances are somebody else knows about the problem and possibly is exploiting it," says Grand. "That's costing all of us taxpayers money.""

Comment Re:Why? (Score 5, Informative) 109

The insulin molecule has two patches on its surface that are predominantly hydrophobic (water-hating) that likely help it to stick to the pure-carbon surface of (nano)diamond. The "nano" bit just insures there is a large amount of surface area for insulin to stick to per unit mass of diamond. The investigators only showed that their nanodiamonds can suck up a lot of insulin; they are far from proving their insulin-loaded nanodiamonds are useful for wound-healing. The investigators only speculate that insulin would act as a growth hormone (generally thought to be its minor function; the major function being the transsystem signal for organism-wide glucose homeostasis). They point out the pH in a typical wound could approach 10.5, which would facilitate insulin release from nanodiamonds. (Such increases in alkalinity in beta cells, the pacreatic cells that produce insulin, are thought to trigger its release.) Unfortunately, it might also compromise insulin's ability to dock with its receptor, a necessary requirement for its function (either as a growth hormone or in glucose regulation). Directly injecting insulin into wounds speeds healing (sometimes by 50%) (Zhang et al, J. Surg. Res. 142:90 (2007) link), so it seems like the investigators have a plausible path to follow.

Comment Re:Whose energy are we stealing? (Score 2, Insightful) 301

There is no way windmills reduce the amount of wind so much as to affect things like seed dispersal. The area perpendicular to the wind velocity is enormous and windmills occupy a very small fraction of that. Windmills siphon a relatively small amount of the air's kinetic energy, most likely smaller than the amount of kinetic energy that ends up does nothing useful whatsoever.
The Almighty Buck

Submission + - Market manipulation by millisecond trading

cfa22 writes: Nice NYT piece today on ultrafast trading on the NYSE and other markets. The "algos" that make autonomous trading decisions have to be fast, but I wonder: Is network speed ever a bottleneck? Can anyone with inside experience with millisecond trading provide some details for the curious among us regarding hardware architectures and networking used for such trading systems?

Comment Re:If only we understood the architecture (Score 1) 539

Graphics boards? They're arrays of SIMD parallel processors driven to execute the same commands on different chunks of data... they can't signal one another the same way neurons do. But, one might imagine programming a GPU to replicate the function of a part of the brain comprised of many neurons, and then interconnect many GPUs, each programmed uniquely, to reconstitute the functionality of a whole brain.

Slashdot Top Deals

"It's the best thing since professional golfers on 'ludes." -- Rick Obidiah

Working...