The only way to make it work is with an inhuman amount of brutality. It is within our power to eradicate their entire territory with nuclear weapons, and I promise you, nothing will rise up there to take its place (not for a few hundred years until the radiation dies down anyway). The rest of the world may then turn against the United States, but the ISIS problem would be 100% solved.
In other words, no, it never really works. That level of violence is self-defeating. ISIS is finding that much out themselves though, because all their Muslim neighbors (and *especially* Jordan) hate them with a passion. I agree that the U.S. needs to help put a stop to them, but cancers like ISIS do tend to get killed off pretty handily by the rest of the world.