Have some F about Trend Micro, but don't have any U or D - TM is one of the worst AV programs I've seen in action.
Back around 2003, the corporate parent of my little used-to-be-locally-owned business set up a "19th hole" deal with TM. We were told to use TM as our sole AV in our local branch, as we now had a corporate-wide license. We refused, and were told that our AV must then come out of our own IT budget. Fair enough.
Why did we refuse TM? For one, the version we were given at that time had to be installed by hand on every machine. Corporate IT actually went through their thousands of machine and installed the damn thing. Probably using interns, as it wouldn't have been cost effective to have actual IT do that work, despite their sweetheart deal with TM. With an IT staff of 3, only one of which was on desktop support, we didn't feel that it was worth a hand-install on 150 or so machines. Especially since almost everything about TM sucked.
So we shelled out for Norton Corporate, set up a beefy desktop as a dedicated AV server, and pushed the client to all the local machines. 15 minutes of visual inspection plus the help of the rest of the employees found the dozen or so that didn't install properly, and those were dealt with by hand.
A few months later, corporate got slammed with some hellacious worm. TM didn't pick it up at all. In the least. While it spread like wildfire from one of our local corporate goons' laptops onto our systems, Norton at least disarmed all the tens of thousands of copies it placed throughout most of our file systems. (The bastard was doing auditing, and had access to just about everything.)
Corporate was unable to deal with the worm for a few days - we firewalled them off, cleaned up the mess, and got on with life before their IT was able to send us instructions on how to deal with it, and how to fix TM, which it had destroyed in the process. (Yes, every machine by hand, once again.)
So long ramble short - don't listen to TM. Ever.