Comment Re:What the hell? (Score 4, Informative) 646
The argument against fructose has to do with the way the GLUT transporters are regulated. Glucose uptake into the liver is regulated by insulin mediated GLUT4 translocation and GK etc preventing too much of it from going into the liver and getting converted to FA/VLDL and so forth. Fructose can only be metabolised in the liver (unlike glucose) and its uptake into the liver is not insulin mediated as it is transported in by GLUT2.
On the other hand, you could make the argument that sucrose is at least half as bad as fructose since it has about half amount of fructose by weight but fructose is sweeter than sucrose by weight so if one uses the proper proportion it isn't that much worse..