The kind of studies you ask for in humans would generally be considered unethical. Even if ethical, they are expensive, and such results don't profit drug companies, so they are rare. So, in humans, we are left with small "gold standard" double-blind controlled studies and larger observational epidemiological studies. A lot of infectious disease were already greatly reduced through improved sanitation, handwashing, quarantine, and better nutrition and lifestyle/behavioral choices (such as not drinking from a common cup and bucket of water on a train as once was common) as well as some curative medicines (antibiotics, phage therapy, etc.) before vaccines came along.
However, I challenge you to supply the same sorts of studies you request for all the specific current formulations of vaccines currently in use today. If you look for such studies in animals, you may find at least some popular vaccines do not work as well as you might think. For example, consider:
http://news.sciencemag.org/hea...
"The current vaccine for whooping cough, or pertussis, may keep you or your baby healthy, but it may not stop either of you from spreading the disease, a new animal study suggests. Baboons can harbor and spread the disease even after receiving the vaccine, researchers have found. ... As expected, the unvaccinated baboons developed severe whooping cough, while the baboons that had been sick previously remained well, the research team reports today in the Proceedings of the National Academy of Sciences. Both groups of vaccinated animals also remained healthy. However, the germ persisted an average of 35 days in the throats of baboons vaccinated with the acellular shot, though it grew less thickly than it did in the throats of the sick, unvaccinated animals. Baboons vaccinated with the whole-cell shot harbored the germ for 18 days, and it did not grow at all in animals that previously had recovered from pertussis."
Note that the baboons that actually had the disease did not pass it on, unlike those who had been vaccinated. Vaccine-based immunity fades fairly quickly for pertussis. It is possible that when people get whooping cough as older children or adults (when it is more manageable) and nursing mothers pass that immunity on to their infants, there may be less mortality among infants from the disease. One problem with many vaccines is that since they fade quickly, you need life-long booster shots, which for dozens of disease could add up potentially to thousands of shots over a lifetime -- each one with a risk of being a mis-manufactured "hot lot" or being mis-injected or being worthless because the disease evolved. Even if each shot may seem to make sense, the total cost for the individual and society of getting on the treadmill of artificial immunity may be quite high. For example, consider the lifetime burden of aluminum from 100 or so annual flu shots.
Of the related research easy to find on exercise and nutrition and disease transmission, here are a few of them:
http://www.ucdenver.edu/academ...
"Children with poor nutrition are at increased risk of pneumonia. In many tropical settings seasonal pneumonia epidemics occur during the rainy season, which is often a period of poor nutrition. We have investigated whether seasonal hunger may be a driver of seasonal pneumonia epidemics in children in the tropical setting of the Philippines. In individual level cohort analysis, infant size and growth were both associated with increased pneumonia admissions, consistent with findings from previous studies. A low weight for age z-score in early infancy was associated with an increased risk of pneumonia admission over the following 12 months (RR for infants in the lowest quartile of weight for age z-scores 1.28 [95% CI 1.08 to 1.51]). Poor growth in smaller than average infants was also associated with an increased risk of pneumonia (RR for those in the lowest quartile of growth in early infancy 1.31 [95%CI 1.02 to 1.68]). At a population level, we found that seasonal undernutrition preceded the seasonal increase in pneumonia and respiratory syncytial virus admissions by approximately 10 weeks (pairwise correlation at this lag was 20.41 [95%CI 20.53 to 20.27] for pneumonia admissions, and 20.63 [95%CI 20.72 to 20.51] for respiratory syncytial virus admissions). This lag appears biologically plausible. These results suggest that in addition to being an individual level risk factor for pneumonia, poor nutrition may act as a population level driver of seasonal pneumonia epidemics in the tropics. Further investigation of the seasonal level association, in particular the estimation of the expected lag between seasonal undernutrition and increased pneumonia incidence, is recommended."
Vitamin D deficiency may be a factor there as well, since people tend to stay indoors more during the rainy season.
http://en.wikipedia.org/wiki/V...
"Along with poor diet there is a large amount of infection and disease present in many developing communities. Infection is very draining on vitamin A reserves and this vitamin A deficit leaves the individual more susceptible to infection (Combs, 1991); increased documentation of xerophthalmia has been seen after an outbreak of measles and the varying stages of xerophthalmia become a good reference point for the extent of deficiency (with mortality increasing with severity of the eye disease). In a longitudinal study of preschool Indonesian children it was found that susceptibility to disease increased nine times when severe VAD was present (Dole 2009). The reason for the increased infection rate in vitamin A deficient populations is due to the T-killer cells which require retinoids to proliferate correctly (Athanassiades1981). Retinoic acid binds the promoter region of specific genes and so activates the transcription process and therefore cell replication (Baron 1981). A vitamin A deficient diet will have a very limited surplus of retinol and so cell proliferation and replication will be suppressed, contributing to a reduced number of T-cells and lymphocytes. Suppression of these will result in a lack of immune reaction if pathogens become present in the body and consequently a greater susceptibility to incubation of disease."
http://en.wikipedia.org/wiki/D...
"Malnutrition, the immune system, and infectious diseases operate in a cyclical manner: infectious diseases have deleterious effects on nutritional status, and nutritional deficiencies can lower the strength of the immune system which affects the body's ability to resist infections.[12] Similarly, malnutrition of both macronutrients (such as protein and energy) and micronutrients (such as iron, zinc, and vitamins) increase susceptibility to HIV infections by interfering with the immune system and through other biological mechanisms. Depletion of macronutrients and micronutrients promotes viral replication that contributes to greater risks of HIV transmission from mother-to-child as well as those through sexual transmission.[13] Increased mother-to-child transmission is related to specific deficiencies in micronutrients such as vitamin A.[14][15] Further, anemia, a decrease in red the number of red blood cells, increases viral shedding in the birth canal, which also increases risk of mother-to-child transmission.[16] Without these vital nutrients, the body lacks the defense mechanisms to resist infections.[12]"
http://www.ncbi.nlm.nih.gov/pu...
"Conclusion: Low 25(OH)D3 serum levels are associated with high levels of HBV replication in patients with CHB. This represents a major difference from chronic hepatitis C, where numerous previous studies have shown a lack of correlation between HCV viral load and vitamin D serum levels. Inverse seasonal fluctuations of 25(OH)D3 and HBV DNA serum levels are suggestive of a functional relationship between both variables."
Pro and con claims about sugar:
http://usatoday30.usatoday.com...
"In the study, researchers at Loma Linda University gave volunteers 100 grams of sugar (20 teaspoons, roughly the amount in a liter of soda). The researchers then drew blood from the volunteers and mixed in some bacteria. They found that infection-fighting white blood cells from people who had just gorged on sugar gobbled up many fewer bacteria than those who had just fasted or eaten an unsweetened starch. But that's not evidence that would convince most doctors, says Aaron Glatt, an infectious-disease specialist who is president and chief executive officer of New Island Hospital in Bethpage, N.Y. Glatt says he has heard of the sugar theory, but as far as he knows, there are no studies showing people who eat a lot of sugar actually get more cases of colds and flu."
Of course, there are be "no studies" that show something because it is not a profitable area either financially or academically to be in. Absence of evidence is not evidence of absence.
From 1951 on studies connecting sugar and polio -- would be interesting to redo those tests with modern methods:
http://www.mercola.com/article...
"Diet Prevents Polio, by Benjamin P. Sandler, M.D."
On exercise:
http://well.blogs.nytimes.com/...
"Being physically fit has been found in many studies to improve immunity in general and vaccine response in particular. In one notable 2009 experiment, sedentary, older adults, a group whose immune systems typically respond weakly to the flu vaccine, began programs of either brisk walking or a balance and stretching routine. After 10 months, the walkers had significantly improved their aerobic fitness and, after receiving flu shots, displayed higher average influenza antibody counts 20 weeks after a flu vaccine than the group who had stretched.
But that experiment involved almost a year of dedicated exercise training, a prospect that is daunting to some people and, in practical terms, not helpful for those who have entered this flu season unfit.
So scientists have begun to wonder whether a single, well-calibrated bout of exercise might similarly strengthen the vaccine's potency.
To find out, researchers at Iowa State University in Ames recently had young, healthy volunteers, most of them college students, head out for a moderately paced 90-minute jog or bike ride 15 minutes after receiving their flu shot. Other volunteers sat quietly for 90 minutes after their shot. Then the researchers checked for blood levels of influenza antibodies a month later.
Those volunteers who had exercised after being inoculated, it turned out, exhibited "nearly double the antibody response" of the sedentary group, said Marian Kohut, a professor of kinesiology at Iowa State who oversaw the study, which is being prepared for publication. They also had higher blood levels of certain immune system cells that help the body fight off infection."
If exercise boosts immune response to vaccines, it would stand to reason it will boost response to real disease, too.
Much of science involves making, refining, and testing models. As is said here:
http://www.ncbi.nlm.nih.gov/pm...
"Transmission experiments are suitable for determining the effect of vaccination on horizontal transmission of infectious agents (11). The key parameter is the reproduction ratio, which is the expected number of secondary cases produced by a typical infected individual during its entire period of infectiousness in a completely susceptible population (12). The aim of vaccination is to reduce the reproduction ratio (R) to a level less than 1 (R 1, the epidemic might not stop and major outbreaks can occur"
My conjecture is that taken together, all the things I listed (eating well, avoiding junk food, getting enough vitamin D and iodine, good sleep, homeschooling, working from home, laughing, exercising, and so on -- even buying stuff online), taken together when done across a society (in a "BlueZones" way) these things would help keep R less than 1.0 for most infectious diseases. And these suggestions would do it in a way that in general promotes higher quality of life for robustly healthy individuals. If you are really interested in this field, maybe you will be the one to prove if to your own satisfaction? Its a bit cruel, but you could compare the spread of some disease in two colonies of rats -- one fed normal rat chow for a week and one fed only sugar water for a week.
Of course, perhaps the really interesting rat studies may tend to get de-funded and forgotten about?
http://en.wikipedia.org/wiki/R...
"Alexander's hypothesis was that drugs do not cause addiction, and that the apparent addiction to opiate drugs commonly observed in laboratory rats exposed to it is attributable to their living conditions, and not to any addictive property of the drug itself.[1] He told the Canadian Senate in 2001 that prior experiments in which laboratory rats were kept isolated in cramped metal cages, tethered to a self-injection apparatus, show only that "severely distressed animals, like severely distressed people, will relieve their distress pharmacologically if they can."[2]
To test his hypothesis, Alexander built Rat Park, an 8.8 m2 (95 sq ft) housing colony, 200 times the floor area of a standard laboratory cage. There were 16-20 rats of both sexes in residence, an abundance of food, balls and wheels for play, and enough space for mating and raising litters.[3]:166 The results of the experiment appeared to support his hypothesis. Rats who had been forced to consume morphine hydrochloride for 57 consecutive days were brought to Rat Park and given a choice between plain tap water and water laced with morphine. For the most part, they chose the plain water. "Nothing that we tried," Alexander wrote, "... produced anything that looked like addiction in rats that were housed in a reasonably normal environment."[1] Control groups of rats isolated in small cages consumed much more morphine in this and several subsequent experiments.
The two major science journals, Science and Nature, rejected Alexander, Coambs, and Hadaway's first paper, which appeared instead in Psychopharmacology, a respectable but much smaller journal in 1978. The paper's publication initially attracted no response.[4] Within a few years, Simon Fraser University withdrew Rat Park's funding.[5]"
The war on drug users is far too profitable to some to be slowed by evidence. Likewise, most angioplasties are a scam:
https://www.drfuhrman.com/libr...
"Trying to figure out how to pay for ineffective and expensive medicine by politicians will never be a real solution. People need to know they do not have to have heart disease to begin with, and if they get it, aggressive nutrition is the most life-saving intervention. And it is free."
Anyway, doctors used to say smoking was good for you too...
http://www.ncbi.nlm.nih.gov/pm...
"In the 1930s and 1940s, smoking became the norm for both men and women in the United States, and a majority of physicians smoked. At the same time, there was rising public anxiety about the health risks of cigarette smoking. One strategic response of tobacco companies was to devise advertising referring directly to physicians. As ad campaigns featuring physicians developed through the early 1950s, tobacco executives used the doctor image to assure the consumer that their respective brands were safe."
And those people who opposed smoking were hounded from their jobs:
http://www.soilandhealth.org/0...
"Also, in 1927, the New York Evening Graphic lets Dr. Shelton go because he will not co-operate with their advertisement policies and insists on running an anti-smoking article."
Hand washing by surgeons after doing autopsies and then delivering babies used to be thought to be an "ungentlemanly" idea:
http://en.wikipedia.org/wiki/I...
Leaded gas was defended by industry for decades at a huge human cost we are still paying:
http://www.motherjones.com/env...
And so on. There is so much conflict-of-interest in medicine and industry connected to it that it is hard to know who to trust; for example:
http://www.pdfernhout.net/to-j...
"The problems I've discussed are not limited to psychiatry, although they reach their most florid form there. Similar conflicts of interest and biases exist in virtually every field of medicine, particularly those that rely heavily on drugs or devices. It is simply no longer possible to believe much of the clinical research that is published, or to rely on the judgment of trusted physicians or authoritative medical guidelines. I take no pleasure in this conclusion, which I reached slowly and reluctantly over my two decades as an editor of The New England Journal of Medicine. (Marcia Angell)"