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Comment Re:Naive question (Score 2) 245

While I'm not an expert in this field, messenger RNA, like all RNAs, is degraded by RNAses, and there's specific complexes of proteins (such as the exosome complex) that target messenger RNA specifically for destruction. If you don't have anything producing more mRNA in the cell, then, eventually the injected mRNA will be degraded and no more translation of it will occur. Because this vaccine isn't rewriting the cell's DNA (unlike the virus itself), there's nothing to produce further mRNA encoding the spike proteins.

The lifetime of mRNA in mammals ranges from a few minutes to a few days; the exact mechanism that controls the lifespan isn't well understood.

Comment Re:Bullshit! (Score 3, Insightful) 132

Given that this article is an opinion piece from Bloomberg from an author whose articles are about competitive pressures and stock prices in the technology sector, calling him or what he's proposing "socialist" is more than a bit of a stretch, I think.

Instead, I think it's more accurate to say Mr. Culpan is thinking of what will make for Shareholder Value, anti-trust laws be damned. That's not very "socialist" at all.

Piracy

How TV Pirates Accidentally Pushed a 25-Year-Old Indie Song to the Top of the Charts in Japan (gizmodo.com) 43

Last week, an alt-rock mystery puzzled the music press. Almost 25 years after its release, the Dinosaur Jr. song "Over Your Shoulder" appeared at number 18 on Japan's Hot 100 chart, beating out major new releases like Ariana Grande's "7 Rings." Here's what drove the popularity of the old song: More than 15 years ago, it was used on a Japanese reality show about boxing bad boys. Six years ago, Billboard started counting YouTube plays. And just days ago, YouTube apparently began recommending pirated episodes of that reality show to Japanese users, who seemingly binged it in the thousands, playing "Over Your Shoulder" over and over again in the process.

Comment Re:Remember the early Dyn? (Score 2) 117

I remember those days. I was one of the paid community supporters before they went commercial, and when they did, I got free lifetime custom DNS service for a single domain as well as free lifetime premium service for dynamic DNS in the dyndns.org domain. The quality of Dyn as a provider, and their willingness to keep their end of that deal (unlike, say, Joyent), is why I use them as my registrar and why I've recommended them professionally despite the fact that there are far less expensive alternatives (such as AWS Route 53 or Azure DNS).

Shortly after the deal closes and integration begins, I expect that my lifetime service will be terminated ("to better serve our customers"), the cost will skyrocket (because this is Oracle we're talking about), and I'll be forced to move to another provider. It was fun while it lasted, I suppose...

Comment Re:Don't forget... (Score 4, Informative) 280

Open Powershell as administrator and type:

set-executionpolicy unrestricted -scope localmachine -force

Alternatively, set it through Group Policy (Policies\Administrative Templates\Windows Components\Windows Powershell\Turn on Script Execution, set to "Allow all scripts").

Businesses

Interviews: Ask Martin Shkreli a Question 410

Martin Shkreli has agreed to answer your questions. Shkreli is the co-founder of the hedge fund MSMB Capital Management, the co-founder and former chief executive officer (CEO) of the biotechnology firm Retrophin, and the founder and former CEO of Turing Pharmaceuticals. Shkreli has been active on Twitter about a wide range of topics, including the 2016 presidential election. Most recently, he expressed interest in buying 4chan.

Ask him your questions here, and we'll post the full interview with Shkreli's answers in the near future.

Comment Re:Battle #2, the insurance companies. (Score 1) 226

When sold in Africa, or procured by other organizations, it can be acquired for about 24 cents per pill (International Drug Price Indicator Guide).

Without getting into the dark world of drug pricing, it's clear that $18.58 a pill, which nearly a 75x markup, is probably a wee bit too high, particularly for a drug whose two components aren't exactly on the cutting edge of anti-retroviral therapies.

Submission + - Password storage service LastPass hacked. (cnn.com)

BitterOak writes: LastPass is a service which claims to securely store all your passwords in one safe place. According to this story, it proved not to be quite as safe as claimed. Apparently they were hacked. Hackers obtained people's e-mail addresses, password reminders, and encrypted versions of their master passwords. With these encrypted passwords, hackers could run brute force attacks to obtain weak passwords very easily. And the reminders may help them to figure out more secure passwords as well.

Comment It has "scam" written all over it! (Score 5, Insightful) 175

Beyond the obvious problems with the concept (the cost of goods sold for the coils themselves, the extreme improbability of a kerosene-powered drone built by college students being able to make intercontinental flights, the fact that there's no way in hell the FAA or the State Department would permit such a flight, etc.), there's several big red flags on this that scream "scam:"

  1. The creator of the project has put up two projects on KS before. The most recent, the "Banana Project," is either an attempt to troll or the sort of half-baked (pun intended) project I'd expect from someone who wants to get paid to buy a 3-D printer to screw around with. The earlier project, "Super Mario Bros. Z The Movie, was cancelled and pulled, presumably because Nintendo had an issue with some random guy creating what I can only imagine is an amateur animation project. This is not a good track record, especially since the more recent project is from just three months ago.
  2. The creator has no information on his bio, has not backed any other projects, and has no other real information available. Accountability seems non-existent.
  3. The photo of the putative tesla coil is a vague sketch. There's no other technical information on how they'll be built or what they'll look like. As for the drone, there's no information on how the drone will be built or how it will be controlled. There is no prototype, only hand-waving claims. This screams "vaporware." A good rule of thumb on KS is "never pledge to something unless there's at least a prototype."
  4. The submitter of this Slashdot article is an "anonymous submitter." Who wants to bet that the submitter is actually "Trevor Nestor?"

This KS is an excellent example of a KS from which you want to stay far, far away. Most of the time, the KS community is pretty wise to these sorts of things, but I suppose the combination of "North Korea," "tesla coils," and submissions to Slashdot will lure people in. Don't be a sucker.

Comment Re:It is unfair competition (Score 1) 204

As much as people complain about its occasionally byzantine bureaucracy and its sometimes lapses into small-time corruption (such as giving open terms to the politically powerful), Memphis Light, Gas, and Water (MLGW) serves over 400k subscribers, rapidly fixes outages in a major metropolitan area prone to thunderstorm damage, repeatedly wins awards for reliability of service and water quality, and has a AA bond rating. It offers extremely favorable terms and payment programs for low-income subscribers. Oh, yeah, and it also has .

But hey, municipal utilities can't do anything right, right?

The problem isn't municipal utilities. The problem is poor process and intentional handicapping. When you have neither of these -- for instance, because your municipal utility is run as an independent organization with elected oversight that has actual skin in the game (after all, if you live in the city and use the utility, you have a good reason to not have it suck) -- the results are positive, and there's some great examples of how this works.

Windows

Windows 10: Charms Bar Removed, No Start Screen For Desktops 378

jones_supa writes Late last week, Microsoft pushed out a new build (9926) of Windows 10 to those of you who are running the Technical Preview. The latest version comes with many new features, some easily accessible, others bubbling under, but two big changes are now certain: the Charms bar is dead, and Start Screen for large devices is no more. Replacing the Charms bar is the Action Center, which has many of the same shortcuts as the Charms bar, but also has a plethora of other information too. Notifications are now bundled into the Action Center and the shortcuts to individual settings are still easily accessible from this window. The Start Screen is no longer present for desktop users, the options for opening it are gone. Continuum is the future, and it has taken over what the Start Screen initiated with Windows 8.
Portables

Ask Slashdot: High-Performance Laptop That Doesn't Overheat? 325

AqD writes: Last year we started to replace business/multimedia-grade laptops with gaming laptops at work, after several years of frustration with overheating and throttling issues that plagued our laptops from Acer, ASUS, Dell, Lenovo, and basically every brand you can find on market, making it impossible to write code and run db/test environment all on the same laptop.

The first new batch comes from Clevo because their gaming laptops don't look like gaming laptops, and they offer 3-6 disk slots which we badly need. The result is acceptable, however, not quite as good as I had expected. Mine has i7-4700mq CPU which is more or less equivalent to an older i7 on the desktop, but its temperature is raised to 70-80C while turbo boost is on, even with the best thermal paste. My friend's i7-4801mq is worse — it could never stay at the advertised 3.6GHz for more than a few seconds before it burns up over 90 and starts to throttle. Its benchmark result is nearly identical to the 4700mq because of heat problems. And it's only 3.6GHz! The best i7 CPU on a desktop could easily run closer to 5GHz with 6 cores / 12 threads running!

So what should we choose next time? We're not looking for something cool or slim or light. We need real laptops which can at least run prime calculation at advertised turbo boost speed, full cores/threads for an entire day. A nice bonus would be manual fan control plus easy access to the fan for cleaning.

Comment Re: Desparate Microsoft pulls a "Sun Microsystems" (Score 1) 525

While I'm not a lawyer, I would assume that Microsoft would have to keep that promise by the principles of equitable and promissory estoppel. Reliance upon the promise (which has been around for several years now) is reasonable, and so Microsoft attempting to revoke it and sue would immediately cause damage to those who did so. I think an extremely strong argument could be made in court that the promise more or less permanently estops Microsoft from patent actions regarding the .NET Framework.

Television

Fox Moves To Use Aereo Ruling Against Dish Streaming Service 210

An anonymous reader writes A day after a surprise U.S. Supreme Court decision to outlaw streaming TV service Aereo, U.S. broadcaster Fox has moved to use the ruling to clamp down on another internet TV service. Fox has cited Wednesday's ruling – which found Aereo to be operating illegally – to bolster its claim against a service offered by Dish, America's third largest pay TV service, which streams live TV programming over the internet to its subscribers and allows them to copy programmes onto tablet computers for viewing outside the home.

Comment Re:Surprisingly Infrequent (Score 3, Insightful) 564

We use SCCM extensively at my office, and yes, it's entirely possible to tell it to reimage every single computer. You just need to target the deployment at "All Systems" and make it mandatory. My guess is that some admin picked the wrong collection, which is fairly easy to do in SCCM 2007 (2012 has Collection folders, which helps with that), and there's no warning messages -- just a summary of "this deployment is going to these devices, click Finish to do it." Of course, most other mass management tools assume that the admins know what they're doing, so they don't have much in the way of guard rails either.

One of the more obnoxious elements of SCCM is that there's no real way to recall a command you send out; clients pick up policy at periodic intervals, and without manual intervention, they'll just grab the policy and do what it says even if you kill the server in question. You can block deployments by taking down distribution points (if the clients can't grab content, they won't run the deployment), but you still have to be fairly quick about it to stop it.

What we do to prevent these sorts of disasters is implement process around the use of the ConfigMgr console and ensure only the people who know how to use it actually use it. To prevent an OS reimaging incident, our OS deployments go through a static set of collections by process and are always optional (requiring a manual touch, either at PXE boot or in the UI) except for a specific set of collections that are segregated in their own folder and have names and descriptions with scary words that make it clear what's going to happen. For instance, in our "Clean Reimage" folder, we have a collection that says, "Windows 7 Reimage (Clean, PXE, Forced)" with a description to the effect of, "*** A computer placed in this collection will be REIMAGED and LOSE ALL LOCAL DATA. Local state is NOT preserved or transferred. ***" If we were a larger IT organization, we'd probably use SCCM's role-based security to limit access to clean reimages to a specific group of people.

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