Follow Slashdot stories on Twitter

 


Forgot your password?
Close
typodupeerror
×

Comment Re:Masters also forcing users to sell (Score 1) 251

Not only can you not buy GME on Robinhood, but if you own shares of GME Robinhood is magically selling them without you asking

Link to image of Tweet in case Twitter bans user/post.

They bought on margin. Their position got liquidated when they exceeded their margin limits. Happens automatically.

Comment Re:But why that particular cancer? (Score 4, Informative) 63

by sharky611aol.com (#55115899) Attached to: FDA Approves First Cell-Based Therapy For Cancer
IAAPHO (I am a pediatric hematologist/oncologist), so take my comments for what they're worth... TL;DR: This is a big freaking deal. To address your points, ALL was the first drug that CAR-T treatment was approved for for several reasons. 1) It's common, so easier to do the trials. 2) It has good data to support the use of immunotherapy (see blinatumumab, inotuzumab ozogamycin), and this therapy is really just the next step in a long line of improvements in immunotherapy. 3) It's got a good target. Almost all Pre-B ALLs express CD19 and downregulation (the main resistance mechanism for immunotherapy) seems rare (but has been documented in relapsed cases). 4) The cure rate is nowhere near as high as you cite for older children and young adults (currently less than 80% for anyone over 13 years.). THIS is actually where most of the use for CAR-T therapy will come from.

The bigger news is that the TECHNOLOGY for this treatment has been FDA approved. Once you have perfected the cell harvesting/transfecting/culturing/infusing process, it's trivial to plug in a different antigen target into the cassette. And in fact, this is already happening on a large scale. Hop on over to clinicaltrials.gov and search for CAR... We've already got some results from GD2 targeting (neuroblastoma), HER2 targeting (breast cancer and osteosarcoma) and IL-13R2 (glioblastoma multiforme) with promising results. And remember, this is just the first generation of CAR-T therapy to make it to the market. As the technology matures the acceptable uses of it will broaden.

Your zero-sum game argument has been sufficiently debunked below. But suffice to say, this is a true breakthrough technology which will have a huge impact on the field for years to come. But you've gotta start somewhere.

(In bigger news, I think this is the first time in my 18+ years on /. that there's been a pediatric cancer article. That should tell you something...)

Comment Re:Most stock markets ... (Score 1, Informative) 364

Put all these pieces together, and here's what we have: a rise in Chinese share prices in the last year that seemed to be driven more by investor psychology than by anything fundamental

Lately this seems to be how stock markets work.

It has nothing to do with actual value, just the psychotic glee of investors and speculators who envision doubling their money every six months.

The stock market has become separated from reality, with the people running the giant pyramid scheme feeling entitled to skim off the top with high-frequency trading.

In the long term, the assumptions used in the stock market seem to be irrational, unsustainable, and pretty much impossible. And corporations are often overvalued based on valuations which is more than the company will ever earn in the next few centuries.

Stock markets are going to fuck up our economies more than they seem to be helping. Because they stopped having anything to do with fundamentals and sane valuations a VERY long time ago.

The stock market is a reflection of mass delusion and wishful thinking.

Sorry, that's false. The stock market (rather accurately) reflects the earnings and intrinsic values of the underlying companies (at least in the US). Values are a little bit frothy right now as we're 6 years into a bull market, but well within historical norms. The Shiller price:earnings ratio is around 25 right now, with the historical average being around 16-18 depending on your timescale.

http://www.multpl.com/shiller-pe/

Sure, there are plenty of people making money off the stock market and investors do dumb things, but the fundamentals of the stock market haven't changed.
Networking

The Standards Wars and the Sausage Factory 234

Posted by timothy from the these-things-take-time dept.
Esther Schindler writes "We all know how important tech standards are. But the making of them is sometimes a particularly ugly process. Years, millions of dollars, and endless arguments are spent arguing about standards. The reason for our fights aren't any different from those that drove Edison and Westinghouse: It's all about who benefits – and profits – from a standard. As just one example, Steven Vaughan-Nichols details the steps it took to approve a networking standard that everyone, everyone knew was needed: 'Take, for example, the long hard road for the now-universal IEEE 802.11n Wi-Fi standard. There was nothing new about the multiple-in, multiple-out (MIMO) and channel-bonding techniques when companies start moving from 802.11g to 802.11n in 2003. Yet it wasn't until 2009 that the standard became official.'"
Space

New Type of Star Can Emerge From Inside Black Holes, Say Cosmologists 193

Posted by Soulskill from the cross-black-holes-off-your-list-of-good-hiding-places dept.
KentuckyFC writes "Black holes form when a large star runs out of fuel and collapses under its own weight. Since there is no known force that can stop this collapse, astrophysicists have always assumed that it forms a singularity, a region of space that is infinitely dense. Now cosmologists think quantum gravity might prevent this complete collapse after all. They say that the same force that stops an electron spiraling into a nucleus might also cause the collapsing star to 'bounce' at scales of around 10^-14cm. They're calling this new state a 'Planck star' and say its lifetime would match that of the black hole itself as it evaporates. That raises the possibility that the shrinking event horizon would eventually meet the expanding Planck star, which emerges with a sudden blast of gamma rays. That radiation would allow any information trapped in the black hole to escape, solving the infamous information paradox. If they're right, these gamma rays may already have been detected by space-based telescopes meaning that the evidence is already there for any enterprising astronomer to tease apart."
Businesses

Is Intel Selling Bay Trail Chips Below Cost? 156

Posted by timothy from the consumers-win dept.
edxwelch writes "An analyst at Bernstein Research has found that Intel is selling their tablet Bay Trail chips to OEMs below cost, concluding that after end rebates, Intel's tablet revenues are likely to be "close to zero," while profits will be negative. Intel has responded that the 'special costs' Intel is incurring are not pushing down gross margin. Intel needs to offer the subsidies to OEMs building $199-$299 devices to bring the bill of materials down and make them competive with cheaper chips from the likes of MediaTek and Rockchip."
Bitcoin

The Bitcoin Death Star: KnC Plans 10 Megawatt Data Center In Sweden 250

Posted by timothy from the you'll-heat-up-the-whole-place dept.
1sockchuck writes "Bitcoin hardware vendor KnC Miner has begun construction on a a 10 megawatt data center in Sweden that it will fill with high-powered computers mining for cryptocurrency. KnC has emerged as a leading vendor in the volatile market for ASIC mining rigs, focusing on underpromising and overdelivering. One goal of its move into cloud mining is to cushion any fallout from delivery delays on new hardware, which have been a sore point for miners in the fast-moving Bitcoin market. "Over the next few months we are bringing online enough hashing power to make sure that any delay in the Neptune timeline will be compensated with a completely free hosted hashing packages to all fully paid customers," KnC says in its newsletter."
Sony

Sony Selling Off VAIO Computer Business 204

Posted by timothy from the turns-out-it-wasn't-vaioable dept.
Kensai7 writes "Confirming reports from earlier in the week, Sony has announced plans to sell off its VAIO computer division to a Japanese investment fund. Japan Industrial Partners (JIP) will take control of the operation for an undisclosed fee, and Sony will 'cease planning, design and development of PC products.' For a variety of reasons 'including the drastic changes in the global PC industry,' Sony says 'the optimal solution is to concentrate its mobile product lineup on smartphones and tablets and to transfer its PC business to a new company.'" I have some nostalgia for the tiny old VAIO laptops; I wish more companies incorporated the swiveling camera that they came with.

Submission + - Slashdot BETA Discussion (slashdot.org) 60

Submitted by mugnyte
mugnyte writes: With Slashdot's recent restyled "BETA" slowly rolled to most users, there's been a lot of griping about the changes. This is nothing new, as past style changes have had similar effects. However, this pass there are significant usability changes: A narrower read pane, limited moderation filtering, and several color/size/font adjustments. BETA implies not yet complete, so taking that cue — please list your specific, detailed opinoins, one per comment, and let's use the best part of slashdot (the moderation system) to raise the attention to these. Change can be jarring, but let's focus on the true usability differences with the new style.

Comment Beta blows (Score 4, Insightful) 127

So I guess I still haven't been forced over to the dark side yet, but I went to try it out again to just see if it still sucks as bad as last time. And yup, it does. Completely unreadable, absurd amount of scrolling, ridiculous forced spacing, asinine column widths. Seriously, what's it going to take to make this die?
NASA

NASA Pondering Two Public Contests To Build Small Space Exploration Satellites 127

Posted by samzenpus from the build-it-for-us dept.
coondoggie writes "NASA today said it was looking into developing two new Centennial Challenge competitions that would let the public design, build and deliver small satellites known as Cubesats capable of operations and experiments near the moon and beyond. The first challenge will focus on finding innovative ways to allow deep space communications with small spacecraft, while the second focuses on primary propulsion for small spacecraft."
Programming

HTML5 App For Panasonic TVs Rejected - JQuery Is a "Hack" 573

Posted by samzenpus from the lets-try-this-again dept.
An anonymous reader writes "I have been working on an HTML5 app for Panasonic VIERA TVs, specifically a client for the Plex Media Server. After paying $129 for the developer program, version 1.0 was submitted for inclusion in their VIERA Connect marketplace several weeks ago. After a few requested tweaks, they inquired about how the client communicated with the Plex Server. As many/most web developers do, I used jQuery and its $.ajax call (which is just a wrapper for XMLHttpRequest()). They insisted this was not standard Javascript, and after several communications with them, they replied back with "A workaround like this is considered a hack.". I'm stunned that anyone familiar with HTML would consider jQuery a hack. I've been patient in attempting to explain how jQuery works, but I am getting nowhere. Any thoughts on how I can better explain jQuery to an app reviewer? Yes, I know I can write my app without any Javascript library, but I am really hoping avoid that."
Biotech

Designer Seeds Thought To Be Latest Target By Chinese 164

Posted by samzenpus from the nice-seeds dept.
An anonymous reader writes "Economic espionage is nothing new but one of the biggest areas being targeted now is agriculture. Here's a story about a FBI investigation to track down theft of seeds from research farms. 'The case of the missing corn seeds first broke in May 2011 when a manager at a DuPont research farm in east-central Iowa noticed a man on his knees, digging up the field. When confronted, the man, Mo Hailong, who was with his colleague Wang Lei, appeared flushed. Mr. Mo told the manager that he worked for the University of Iowa and was traveling to a conference nearby. When the manager paused to answered his cellphone, the two men sped off in a car, racing through a ditch to get away, federal authorities said.'"

Slashdot Top Deals

"Sometimes insanity is the only alternative" -- button at a Science Fiction convention.

Close